biochem lecture 9 pt 2 Flashcards
(49 cards)
another name for pentose phosphate pathway
hexose phosphate shunt
what are products of pentose phosphate pathway
NADPH, ribose-5-phosphate
what is NADPH
pyridine nucleotide used for reductive biosynthesis (fatty acids, cholesterols, nucleic acids)
what else is NADPH important for
elimination of oxygen radicals
what is ribose-5-phosphoate important for
ribonucleotides; RNA, DNA, some coenzymes
what is a major producer of NADPH
pentose phosphate pathway
what is NADPH
a form of reducing power important for biosynthesis reactions like fatty acids, cholesterol, nucleic acids, AAs
what does NADPH serve as a major source of
major source of electrons for formation of synthesis of molecules
what else is nadph important for
elimination of oxygen radicals (reactive oxygen species)
what can oxygen radicals cause
oxidative damage; disease etc.
what else does pentose phosphate pathway do
produces ribose-5-phosphate
what is ribose-5-phosphate
important precursor for ribonucleotide and nucleotide biosynthesis (RNA, DNA, coenzymes)
where does pentose phosphate pathway occur
liver, mammary glands, adrenal glands, adipose tissue
where does pentose phosphate pathway NOT occur
brain and muscle
where in the cell does pentose phosphate pathway occur
cytosol
what are 2 stages of pentose phosphate pathway
oxidative stage and non-oxidative stage
what stage is NADPH produced
oxidative stage
why is the first step of oxidative stage important
because this is where regulation of pentose phosphate pathway occurs
what is first step of pentose phosphate pathway
glucose-6-phosphate –> 6 phosphogluconolactone
what enzyme
glucose-6-phosphate dehydrogenase
what can you do in this first step
regulate this pathway
how can you shut down this pathway
by allosterically inhibiting glucose-6-phosphate dehydrogenase
what step do you generate NADPH
step 1
how many times do you generate NADPH
2 times in oxidative stage
