Biochemistry 🧪

Question 1

Beri beri

Answer 1

Carb rich diet
Thiamine B1 deficit

Question 2

Pellegra

Answer 2

3Ds
Dermatitis
Dementia
Diarrhea

Niacin B3 deficit

Question 3

Wernicke Korsakoff Syndrome

Answer 3

Severe thiamine B1 deficit

Question 4

Pernicious Anemia

Answer 4

Malabsorption&raquo_space;> B12 deficit
Loss of intrinsic factor

Question 5

Xeroopthalmia

Answer 5

Dryness of cornea and conjunctiva
Due to over keratinization of cornea

Question 6

Itchy burning eye ,bloodshot eyes
Angular stomatitis .chieolosis
Seborrhea ( dandruff)
Photophobia
Vit Deficit?
Derive from milk/egg/cereal / meat

Answer 6

Riboflavin B2
Seen in alcoholic

Question 7

NAD+ / NADP+ derived from which vitamin ?

Answer 7

B3 Niacin
B3 Act as cofactor for redox reaction

Question 8

Niacin derived from which aminoacid ?

Answer 8

Tryptophan
Also B1/ 2/6 required for Niacin synthesis

Question 9

Which vitamin derivative can treat and lower hyper cholesterolemia?

Answer 9

Nicotine Acid
B3- Nicotinic acid + nictotinamide

Question 10

Penicillimine ( used to treat for RA and Cystinuria ) can lead to which Vit deficit ?
Hint : Vit is important cofactor for GABA synthesis

Answer 10

B6 - PLP ( active form )
Insomnia
Muscular control
Leg cramps
Dermatitis
Slow learning
Sluggish

Question 11

B12 and folate deficit lead to anemia . Why?

Answer 11

Folate trap
B12 cofactor for methionine synthesis from homocysteine
Cannot synthesis nucleotides (DNA) for Hgb
NYs- purine and thymidine

Question 12

Complication of homocystinuria

Answer 12

CVS diseases&raquo_space; neg impact on collagen and elastin for arteries /bones / joints /etc
Thrombosis