Biologics and Anti-TNF Flashcards
1
Q
What are the 4 types of antibodies we use
A
Mouse, chimeric, humanised, human
1
Q
What does TNF-a do?
A
inflammatory cytokine produced by macrophages/monocytes during acute inflammation
Prothrombic action
Growth factor
Induces other cytokines
Regulates haematopoiesis
Induces endothelial adhesion molecules
2
Q
What is infliximab?
A
chimeric (part human part mouse) anti-TNF MAB
3
Q
What is Etanercept?
A
Recombinant soluble human TNF linked to human immunoglobin
4
Q
What are IL-6 and Jak inhibitors?
A
Biologics!
5
Q
How do JAK inhibitors work
A
For severe RA
Offered when DMARDS don’t work
Prevent STAT from being phosphorylated and therefore prevent gene transcription
6
Q
Name a JAK inhibitor
A
either Tofacitinib or Baricitinib
