Biology Module 4 Flashcards

Biodiversity and disease (71 cards)

1
Q

What is Biodiversity defined as?

A

Biodiversity refers to the measure of the variation found in the living world.

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2
Q

What are the 3 types of diversity?

A

-Species diversity, a measure of the number of species present in a habitat
-Habitat diversity, a measure of the number of different habitats for different species in an area
-Genetic diversity, a measure of the variation in a breeding pool of a species

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3
Q

What are the 2 different types recording data using a transect line?

A
  1. Line transect - Only recording species that touch the line
  2. Belt transect - Using a quadrat at regular intervals along the line to provide a greater volume of results
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4
Q

What is species richness?

A

It refers to the number of different species found in a habitat. This is measured by taking random samples of a habitat and counting the number of species found.
Higher number of species = Higher species richness

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5
Q

What is species evenness?

A

It refers to the relative abundance of individual species in a habitat. This is measured by taking random samples of a habitat and counting the population of each different species collected.
More evenly balanced population = Higher species evenness
Eg, field full of 20 poppies, and 1 of 30 other types of plants = High species richness, low species evenness as poppies have the highest population

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6
Q

What is Simpsons index?

A

A method of measuring the diversity of a habitat by taking into account both the species richness and species evenness.
D=1-[∑(n/N)2]
D=diversity of habitat
n=total number of organisms of a particular species of % cover
N=total number of organisms in habitat
*observed value D will always be between 1 and 0

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7
Q

What are alleles, locus and genes?

A

-Alleles are are a version of gene
-Locus (plural Loci) is the position of a gene on a chromosome
-Genes are a section of DNA on a chromosome that codes for the aa in a polypeptide chain

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8
Q

What are the three methods for working out the genetic diversity of a habitat?

A
  1. Observing and counting the phenotypes present
  2. Calculating the number of loci in one individual that are heterozygous (not a good measure)
  3. Calculating the percentage of loci in the population that have more than one allele (polymorphic gene loci)
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9
Q

What is polymorphic gene loci, and what is the related equation?

A

Some loci have more than two alleles, which helps increase the genetic diversity of a population as there is a greater variety of alleles that may appear in an organisms genotype.

Proportion of polymorphic gene loci=Number of polymorphic gene loci/Total number of loci x100

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10
Q

What is genetic erosion?

A

The selection of specific breeds of domesticated plants or animals may cause other breeds to die out due to the lack of genetic diversity

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11
Q

What are the 5 main factors affecting biodiversity?

A

-Habitat destruction
-Overexploitation
-Human population growth/actions
-Agriculture
-Climate change

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12
Q

How does Habitat destruction affect biodiversity?

A

Habitat destruction can appear in 2 forms:
-Habitat loss, plants and animals completely lose their habitats for food/agriculture, housing, waste disposal, etc
-Habitat fragmentation, habitats are divided into small areas. Populations in these habitat fragments are more likely to suffer from inbreeding or local extinction
-Deforestation is most damaging type of habitat destruction as forest habitats usually contain very high levels of biodiversity
-Coral reefs are also being destroyed (dynamite fishing damages coral beds)
-Sea beds are being destroyed (fishing practises such as trawling damages this habitat)

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13
Q

How does Overexploitation affect biodiversity?

A

-Resources are being used up faster than they can be replenished, eg, deforestation as trees are being removed faster than they can be replanted/regrow
-Fish stocks also overexploited, causing effects for their larger habitat

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14
Q

How does agriculture affect biodiversity?

A

-A decrease in natural vegetation and habitat size reduction, paired with the increase in monocultures decreases the genetic diversity of a species
-Monocultures also support lower levels of biodiversity, eg, Borneo and palm oil
-Selective breeding leads to genetic erosion and a reduce in genetic diversity
-Fields made bigger to accommodate large machinery by removing hedgerows, an important habitat for small organisms
-Fertilisers can leach into waterways, leading to eutrophication and the death of aquatic organisms
-Pesticides can kill non-target species, like bees, important pollinators
-Filling in ponds/draining wetlands can disrupt migrations

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15
Q

How does Human population affect biodiversity?

A

-As it increases so does the demand for food, water and consumer goods
-Leads to habitats being converted and destroyed for agriculture
-Pollution occurs, eg, SO2 causing acid rain
-More finite resources are overexploited

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16
Q

How does Climate change affect biodiversity?

A

-Due to reduced genetic diversity (caused by monocultures, genetic erosion, etc) some species are less able to adapt to changing conditions so may die out, reducing biodiversity
-This can also occur due to fragmented habitat
-Changing conditions may affect natural migrations of animals due to global warming, so may cause them to die out and reduce biodiversity
-Global warming is also causing organisms to migrate towards the poles or to higher ground
-This can cause species to die out due to inability to live in those new conditions, due to being outcompeted/outcompeting others, or a new disease, all of which reduce biodiversity

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17
Q

What is Extinction and how high are the rates of extinction at this moment in time?

A

-Extinction occurs when the last member of a species dies, causing the species to no longer exist
-Over 800 recorded extinctions since 1500, and 20% species could be extinct by 2030, 50% by 2100
-Current rate of extinction 100-1000x higher than ‘normal’ background rate
-In a mass-extinction event at least 2x as fast as previous mass-extinction events

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18
Q

What is the Convention on Biological Diversity (CBD)?

A

-Signed at earth summit in Rio in 1992
-Countries that signed agreed to implement conservation strategies and instigate further international co-operation
3 main goals:
1. Conservation of biological diversity
2. Sustainable use of resources
3. Fair sharing of benefits arising from genetic resources

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19
Q

What is the Convention on International Trade of Endangered Species of wild flora and fauna (CITES)?

A

-Aims to control endangered species trade
-Categorizes species into 3 appendices
1. Species that are endangered and face threat of extinction, eg, red panda
2. Species not currently endangered but will if trade not regulated, eg, Venus flytrap
3. Species included via a request from a country regulating trade of a species to prevent its overexploitation
Different regulations for each appendix:
1. All trade in a species and its products is banned
2. Permits required from associated countries
3. Permit required, though more easily obtained
-Species continuously added and re-evaluated
-Concern of CITES efficacy as when species is endangered, price rises and so therefore does incentive to break the law

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20
Q

What is the Countryside Stewardship Scheme (CCS)?

A

-Scheme in 1980’s providing funding (incentive) for farmers/land owners in UK who used environmental strategies to conserve biodiversity
-Replaced 2005 with ESS
To qualify:
1. Provide and protect natural habitats
2. Ensure land is well managed
3. Protect natural resources present on their land
4. Conserve traditional crops or animals living on their land
5. Provide visitor learning on conservation

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21
Q

What is a keystone species?

A

A species that defines and maintains an ecosystem/habitat, and without which the habitat may die or become unbalanced, eg, sea otters and urchins.

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22
Q

What the 3 reasons for maintaining biodiversity?

A

Ecological:
-Maintaining keystone species and conserving genetic resources
-Maintaining SSSI’s - Sites of Special Scientific Interest, as these sites can contain important science undiscovered, eg, new drug bases
Economic:
-Reducing soil depletion by stopping the spread of continuous monocultures
-Conserves ecotourism, eg, the redwoods in the USA
-Helps drive scientific advancement, eg, PCR and drug development
Aesthetic:
-To maintain habitats for human mental health

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23
Q

What does ex-situ and in-situ conservation mean, and what are examples?

A

Ex-situ is the conservation of biodiversity by removing it from its natural habitat where it is under threat, and with active human involvement to help conserve it, eg, zoos, seed banks, gardens, etc.
In-situ is the conservation of species in their natural habitat with little to no human involvement, eg, game reserves and marine conservation zones.

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24
Q

What are the 3 domains, and how were they discovered?

A
  1. Eukarya - organism’s who contain nuclei
  2. Bacteria - prokaryotic organisms
  3. Archaea - prokaryotic organisms, that are different to bacterial organisms
    They were discovered by Carl Woese by comparing the genetic code of the 16S ribosomes between animals, as this ribosome is the same in all living organisms.
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25
What is the order of classification?
Dumb King Phillip Came Over For Group Sex Domain, Kingdom, Phylum, Class, Order, Family, Genus, Species
26
What is Phylogeny?
The study of evolutionary relationships between organisms, eg, putting animals in an evolutionary/phylogenic tree.
27
What are Archaea and how are they different from Bacteria?
They are prokaryotic organisms that evolved from Eukarya after bacteria did. They are different from both for a number of reasons: 1. They have 3 RNA polymerase's to code for the 3 different types of RNA, whereas bacteria only has 1 2. Their cell walls do not contain peptidoglycan, unlike bacterial cell walls 3. They have cell membrane that contain lipids with hydrocarbon chains rather than fatty acids
28
Why is binomial nomenclature needed, and what the rules for writing a species name in this way?
It is needed to have a universal and internationally recognised naming system for species, stopping any confusion about species between languages. The way to write the name is to write the genus in a capital letter, the species in a lower-case letter, and in italics or under-lined.
29
What is a species?
A group of organisms that are very similar in appearance, anatomy, biochemistry, physiology and genetics, and can reproduce sexually to produce fertile offspring.
30
What is convergent and divergent evolution?
Convergent evolution is evolution that occurs in organisms that are not related, but are anatomically similar due to being subject to similar evolutionary pressures. Divergent evolution is evolution that results in organisms becoming more anatomically different, represented by a branch from the phylogenetic tree.
31
How are animals placed onto a phylogenetic tree?
-Using a protein called Cytochrome C -This is useful as it a protein used in respiration -This means all eukaryotes have it -Therefore, the primary structure of cytochrome c can be compared across species, using a matrix, to place them on a phylogenetic tree relative to others
32
What are the 2 types of classification?
1. Artificial classification 2. Natural classification
33
What is artificial classification, and what are it's advantages and disadvantages?
Grouping organisms based upon like characteristics, eg, organisms that are orange. Advantages: -Does not changed based upon further knowledge, ie, both organisms will still be orange -Convenient Disadvantages: -Not useful to find the species evolutionary history -Provides limited information, ie, organisms are orange
34
What is natural classification, and what are its advantages and disadvantages?
A detailed study on an organisms many characteristics, eg, genetic, anatomical and molecular evidence. Advantages: -Many different characteristics used -Reflects phylogenetic relationships between species -Provides information on evolutionary history Disadvantages: -May change with further knowledge
35
What are the 4 different types of Variation?
Inter-specific: -The variation found between species Intra-specific: -The variation found between organisms in a species Discontinuous: -Variation caused by solely genetic factors Continuous: -Variation caused by both environmental and genetic factors
36
What is continuous and discontinuous data?
Discontinuous: Data that can be separated into distinct groups, with no middle values, like nominal data, eg, shoe size being 7, 7.5 and 8, not 7.3 Continuous: Data that could be any data value in a range, so there is no distinct separation, like ordinal or interval data, eg, height in cm
37
What are the independent sample and the paired sample t-tests?
Independent sample t-test is a test used to investigate the differences between 2 samples (independent measures design) Paired sample t-test is a test used to investigate differences over time, using the same sample (repeated measures design)
38
What are polygenes?
A large number of genes that work as a group to control or have an effect on one continuous characteristic.
39
What is an adaptation, and what are the 3 different types?
-An adaptation is any variation that helps an organism to survive in its habitat -The 3 types are behavioural, physical and physiological -Behavioural - a variation in how an animal behaves, and certain reflexes -Physical - a change in the physical structure of an organism or cell, eg, bipedalism -Physiological - a variation in the chemical processes of an organism, eg, the ability to anaerobically respire
40
What is disease?
A disorder of the mind or body that causes poor health.
41
What is a pathogen and parasite?
Pathogen: -An infectious microorganism that causes disease -4 main types: viruses, bacteria, fungi and protists Parasite: -An organism that survives in or on another species, usually surviving at their hosts expense
42
How might bacteria act as pathogenic organisms?
-Prokaryotic organisms -They reproduce rapidly via binary fission, bursting out of cells, causing damage, and releasing toxins/waste into the bloodstream, inhibiting enzymes or processes -Some bacteria are non-pathogenic
43
What are the 2 examples of bacterial diseases? (plant + animal)
TB /Tuberculosis (animal): -When infected organisms with the active form of the bacterium cough or sneeze, the bacteria enter the air via tiny droplets of liquid -Transmitted to uninfected individuals inhale these droplets, so TB spread much faster in overcrowded and unhygienic conditions -TB can occur in cows and spread to humans via unpasteurised milk and contaminated meat -Symptoms include a chronic cough and bloody mucus Ring Rot/Rot (plant): -Bacterial disease in potato plants -Bacteria infect vascular tissue and prevent transpiration, even in tubers, where vascular tissue is in a ring, causing typical black ring of rot, and eventual wilting and death
44
How might protoctista act as pathogenic organisms, and what are some examples?
-Eukaryotic organisms that are usually spread via vectors -Divide via mitotic division/reproduce sexually -They can cause damage as they inhabit cells, ingesting the cell inside, use the cytoplasm as a reproductive medium and burst out of the cell, causing pain Malaria: -A protist disease transmitted when a protoctista passes from a vector to a human -Symptoms include fever, chills, fatigue and eventual death Potato/Tomato Blight: -Protist disease with fungal characteristics, as transmitted via spores -First signs are an increasing number and size of brown marks on leaves -Destroys crops leaving them inedible
45
What is the mechanism of malarial infection?
-Female mosquito's fed on human blood to obtain the proteins to develop eggs -If the mosquito bites an infected individual and then an uninfected individual, the plasmodium will pass from one to the other 1.Infected mosquito feeds on an uninfected human 2.Ineffective parasites enter the bloodstream and then the liver 3.Leave the liver and enter erythrocytes 4.Parasites gametes mature and are produced 5.Mosquito takes blood meal and gametes fuse in mosquito's stomach 6.Division occurs and produces many inactive plasmodium's which enter mosquito salivary glands 7.Process occurs again -Due to global warming, more area are becoming habitable to mosquito's, so more cases are occurring -Increased migration and globalisation will also mean more mosquito's will become vectors around the world
46
How might viruses act as pathogenic organisms?
-Not alive, a strand of mRNA surrounded by a protein shell -Reproduce by taking over cell's metabolism and producing more viruses via translation -This reproduction can cause cells to burst, spreading the virus
47
What are 3 examples of viral infections? (plant + animal)
HIV/Human Retro-Virus (animal): -A retrovirus, a virus that can form DNA from RNA, transmitted via a vector -The virus is not able to survive outside the hosts body, and is spread through intimate human contact and the direct exchange of bodily fluids -The viral enzyme reverse transcriptase produces DNA from RNA -DNA is inserted into the hosts DNA and remains inactive for years until it is activated and the DNA provirus produces more viruses Influenza (animal): -3 different types, A, B and C -Infect the cells lining airways causing high temps, aches and fatigue -A is most common, consisting of a proteins shell (capsid) with 8 RNA strands inside it TMV/Tobacco Mosaic Virus (plants): -1st virus ever discovered -Occurs in a number of species, causing distinct mottled discolouring of leaves
48
How might fungi act as pathogenic organisms, and what are some examples?
-Eukaryotic organisms -Reproduce via spores -Can cause the area infected to become uncomfortable, swell or become painful -They feed on living matter, ingesting nutrients and carbs from the host organism Athletes: -Fungal disease existing on the surface of animals skin -Less serious infection than fungal infections in plants Black Sigatoka: -Fungal disease in bananas, spreading through plant leaves, inhibiting photosynthesis -Produces black streaks and causes plant leaves to die
49
What is transmission, and what are the 3 methods?
Transmission is the process of passing a pathogen from an infected organism to a healthy one. 1.Direct Transmission - transmission of a pathogen via direct contact between a healthy and an infected individual, eg, bodily fluids 2.Indirect Transmission - transmission of a pathogen via other mediums such as the air, water, or other objects in the direct environment 3.Vectors - an organism or intermediary that carries a pathogen from one host to another
50
What are the 4 different types of direct transmission?
1.Direct contact refers to transmission via direct physical contact between individuals 2.Faecal-oral refers to transmission via direct contact between the mouth and faecal matter, through a number of mediums, eg, water 3.Droplet refers to transmission via tiny water droplets in the air, from the mouth of an infected organism 4.Spores refers to transmission via small reproductive structures in an environment, which, when in a host, grow and cause infection, eg, potato blight spores and wind
51
What factors affect transmission?
-Overcrowding -Poor nutrition -Compromised immune system -Culture -Socioeconomic status -Waste disposal -Vector distribution
52
What are some passive primary defences of plants against infection?
Cellulose cell wall: -Acts as first barrier to invasion, and though not completely impregnable, has a high density stopping many pathogens Waxy cuticle: -Acts as a physical barrier, limiting direct contact between pathogens and the epidermis, and preventing H20 collection on leaves and so spore germination Bark: -Tough physical barrier blocking pathogens and containing anti-microbial chemicals, inhibiting micro-organism growth Lignin thickening: -Located in secondary cell walls, eg, xylem -Makes cell walls rigid and impregnable and hydrophobic nature stops the transmission of water-borne pathogens
53
What are some active primary defences of plants against infection?
Stomatal closure: -Stomata can close when pathogen-associated molecular patterns (pamps) are detected -Reduced chance of infection via stomata Tylose formation: -Causes swelling of parenchyma around xylem -Blocks xylem, preventing transpiration and places anti-microbial compounds into xylem Callose Deposition: -A polysaccharide, made of β-glucose, deposited between the plasma membrane and the cell wall -Forms barriers around plasmodesmata and sieve tubes, blocking movement between cells and deposited very quickly when a pathogen is detected 1.Callose deposited when a pathogen is detected, preventing further spread 2.Lignin added to callose to strengthen the barrier 3.Blocks sieve plates, preventing spread via the phloem 4.Blocks plasmodesmata between infected and healthy cells
54
What are some active chemical plant defences against pathogens?
Phytoalexin: -A chemical that is released when the breakdown of cellulose is detected, stopping pathogenic invasion from the surface of the plant -Can disrupt the metabolism, reproduction, cell surface membrane of bacteria, or release chitinase enzymes Alkaloids: -A group of nitrogen containing compounds that have physiological effects on pathogens -Often poisonous to pathogens and herbivores, often aa derivatives, eg, caffeine, cocaine and morphine Tannins: -Phenolic (containing benzene) compounds found in root cell vacuoles and cell walls -It is toxic to pathogens and herbivores, preventing infection Saponins: -Chemicals that kill pathogens via destroying cell membranes -This halts the growth and reproduction of pathogens Defensins: -Cysteine kills pathogens via channel protein inhibition, stopping many metabolic reactions within the pathogens, stopping the infection from spreading Hydrolytic Enzymes: -Enzymes that breakdown the cell wall of pathogens, and inhibits pathogenic reproduction VOC (Volatile Organic Compounds) : -Organic compounds that emit chemical signals that either directly repel or attract organisms to help with the defence against pathogens, eg, causing other plants to activate their defences
55
What are some non-specific animal defences against pathogens?
Skin: -Passive defence, with its outer layer consisting of a layer of dead cells impregnated with keratin -This means it is impenetrable to pathogens -Also secretes sebum, an anti-microbial compound that kills pathogens before it can cause infections Nose and Gaseous Exchange system: -Both lined with cilia, bathed in mucus, which is then swept towards the throat to be destroyed in the stomach -Pathogens and dust get caught in viscous mucus -Alveoli covered in mucus membrane containing lysozymes Stomach and Vagina: -Stomach produces HCl with pH ~2-2.5 -Vagina not as acidic at ~4-4.5 -Kills pathogens before they can reproduce Clotting: -Forms a barrier to the wound, acting as a physical barrier and stopping pathogen invasion through the bloodstream
56
How does clotting in the blood occur?
-Platelets, when exposed to the outer protein layer of the blood vessels release a clotting factor, eg, thromboplastin -Thromboplastin causes prothrombin and Ca^2+ to combine to form thrombin -Thrombin then causes fibrinogen to form fibrin -Fibrin forms a mesh with erythrocytes to create a protective layer above the wound, that dries to form a scab
57
What are platelets?
-They are very small fragments of short-lived cells -They are produced continuously in the bone marrow
58
How do Histamines and Cytokines help fight infection?
-Mast cells activated during skin rupture and so release histamines and cytokines Histamines: -They cause vasodilation (vessel dilation), promoting more blood flow to the area and causing heat and redness -This stops pathogens from reproducing due to high *C -Also increases permeability of vessels causing more plasma to leak out to form tissue fluid, leading to swelling and pain -Allows more phagocytes to access the infected area Cytokines: -Attracts phagocytes and leucocytes to the area to kill pathogens -Phagocytes travel to hypothalamus to cause it to reset and increase internal body temp and stop pathogenic reproduction
59
What are opsonins and what is opsonization?
-Opsonins are proteins that attach to foreign antigens on the surface of pathogens, allowing phagocytic cells to denote a pathogen as foreign and destroy it -Opsonisation is an immune process that uses opsonins to tag foreign pathogens for elimination by phagocytes
60
What are antigens, and what are the 2 different types of antigens?
Antigens are proteins extrinsic to the cell-surface membrane that identify a cell as native or foreign to an organism. The 2 different types are self-antigens and non-self-antigens: Self-antigens: Antigens from a native cell Non-self-antigens: Antigens from a foreign cell or toxin
61
What are the 2 main types of phagocytes?
-The 2 main types of phagocytes are neutrophils and macrophages Neutrophils: -They are white blood cells that have a multi-lobed nucleus -They are manufactured in the bone marrow, and they travel via the blood, and can be found in the tissue fluid and on epithelial surfaces -They are released in large numbers during infection as they are short-lived as they die after digesting a couple of pathogens Macrophages: -They are manufactured in the bone marrow, and are larger than neutrophils -They travel in the blood via monocytes, before settling in organs, eg, lymph-nodes, before developing into macrophages -Don't fully digest pathogens, becoming antigen-presenting cells
62
What is the process of phagocytosis?
1.The phagocyte recognises the pathogen via the opsonins on the antigens 2.Receptors on the phagocyte bind to the pathogen antigens 3.The cell-surface membrane invaginates, trapping the pathogen in a phagosome (a vesicle surrounding a pathogen) 4.Lysosomes fuse with the phagosome inside the phagocytes cytoplasm to form a phagolysosome (a cytoplasmic body formed when lysosomes fuse with a phagosome) 5.The lysosomes release enzymes that digest the pathogen, eg, lysin and lysozymes 6.The harmless waster products are either reused by the cell, or ejected from the cell via exocytosis OR 7.The macrophage presents the pathogenic antigens on their cell-surface membrane from the partially digested pathogen
63
What are antigen presenting cells?
-Antigen presenting cells are cells that present foreign antigens to produce a specific immune response -These can be macrophages, invaded body cells or cancerous cells as a sign of cellular distress
64
What is the process of cell-mediated response, and what are T-lymphocytes?
-T-lymphocytes are white blood cells that cause a immune response by dividing and differentiating, and have a complementary receptor for a specific pathogenic antigen -They are produced in the bone marrow and travel via the blood to the thymus gland where they mature 1.The antigen-presenting cell displays the foreign antigen and presents it to a T-lymphocyte 2.If the T-lymphocyte has a complementary receptor, it will bind to the cells, causing it to become activated 3.It then divides by mitotic division with the clones differentiating into 4 different types of T-cells
65
What are the 4 different T-cells present in a specific immune response?
T-memory cells: -Remain in the blood for a long time so they can respond to future pathogenic invasion, from the same pathogen -Retain a memory as they have a specific pathogenic antigen receptor -Can enable a rapid response to a repeated infection, so is a secondary response T-helper cells: -Secrete cytokines to stimulate: -T-killer cells to destroy pathogens -Phagocytes to undergo phagocytosis faster -Stimulate B-lymphocytes to divide and differentiate to become antibody producing plasma cells T-killer cells: -Kills cells that present specific non-self antigens -Kills via a chemical is produces called perforin, making holes in the plasma membrane of the pathogen T-Suppressor cells: -Close down immune system activity when pathogen destroyed
66
What are Autoimmune diseases?
They are disorders where the immune system can no longer recognise self antigens, and so starts attacking native cells and tissues.
67
How do you calculate standard deviation?
SD = √[∑(x-x̄)^2/(n-1) SD=Standard deviation ∑=Sum off x=The data value x̄=The mean of the data n=The number of data values (When calculating x-x̄, do it for every data value before adding them together)
68
What are antibodies, and how are they structured?
-Antibodies are specialised glycoproteins called immunoglobulins -They are specific and bind to only 1 type of antigen, like the lock and key theory for enzymes -When they bind to an antigen, an antigen-antibody complex forms, stimulating digestion via phagocytosis, like opsonins -They consist of 2 heavy chains, in the middle of the proteins, that are arranged in a y shape, joined together via disulphide bridges -2 light chains are then attached to the upper lengths of the heavy chains via more disulphide bridges -The bottom portion is called the constant region, and the area with the light chains changes between antibody molecules and so is called the variable region -The antigen-binding area is found at the end of the variable region and is specific a type of non-self antigen -The centre of the antibody is called the hinge area, and has many disulphide bridges that allow the 2 variable regions to move
69
What 2 processes can be triggered when an antibody binds to an antigen?
-Agglutination and Neutralisation Agglutination: -1 antibody binds to 2 pathogenic non-self antigens, causing them to clump together, and allowing pathogens to be more easily engulfed and digested Neutralisation: -The antibodies can act as an anti-toxin, binding to pathogens and toxins, making them harmless to the organism
70
What are B-lymphocyte cells, and what are the 3 different types of B-lymphocyte cells involved in the humoral immune response?
-B-lymphocyte cells are white blood cells that are made and mature in the bone marrow, before spreading mainly through the lymph-nodes and spleen -As they mature they develop BCR's (B-cell receptors), antibodies that develop extrinsic to the B-cells plasma-membrane, with each being specific to 1 non-self antigen B-effector cells: -These cells divide to form plasma cell clones B-memory cells: -These act like T-memory cells and remain in the blood for a long time, providing a long immunological memory -It actions a more rapid secondary response to repeat infection Plasma cells: -These cells produce antibodies specific to an invading pathogen, living only for a few days, but producing ~2000 antibodies when it is active
71
What is the process of the humoral immune response?
-The humoral immune response is a response to pathogens found in the blood, mainly fungi and bacteria 1.When a B- effector cell binds to a pathogen that has a complimentary antigen to its antibody, it digests it, presenting the non-self antigens 2.The presenting B-effector binds to a T-helper cell with a complimentary receptor, which is called clonal selection 3.The interleukins produced by the T-helper cell activate the B cells to rapidly undergo mitotic division to differentiate into the 2 other B-cells, called clonal expansion 4.Clonal plasma cells produce complimentary antibodies to bind to pathogenic antigens, and causing agglutination or neutralisation, disabling them