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BIOPHARM > Biopharm > Flashcards

Biopharm Flashcards

1
Q

The route of drug administration that gives the most rapid
onset of pharmacologic effect is:
a. intramuscular
b. intravenous
c. intradermal
d. subcutaneous

A

B

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2
Q

The route of drug administration that provides complete
100% bioavailability is:
a. intramuscular
b. intravenous
c. intradermal
d. subcutaneous

A

B

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3
Q

Which condition usually increases the rate of drug
dissolution from a tablet?
a. Increase in the particle size of the drug
b. Decrease in the surface area of the drug
c. Use of the free acid or free base form of the drug
d. Use of the ionized or salt form of the drug

A

D

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4
Q

Which tissue has the greatest capacity to biotransform
drugs?
a. Brain
b. Kidney
c. Liver
d. lung

A

C

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5
Q

The earliest evidence that a drugs is stored in tissue is:
a. an increase in plasma protein binding.
b. a large apparent volume of distribution (VD).
c. a decrease in the rate of formation of metabolites
by the liver.
d. an increase in the number of side effects produced
by the drug.

A

B

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6
Q

The loading dose of a drug is usually based on the:
a. total body clearance of the drug.
b. percentage of drug to plasma proteins.
c. fraction of drug excreted unchanged in the urine.
d. apparent volume of distribution (VD) and desired
drug concentration in plasma.

A

D

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7
Q

Glibenclamide, a sulfonylurea, is classified under BCS II.
Which of the following statements describes this
classification?
a. Low permeability, high solubility
b. High permeability, low solubility
c. High permeability, high solubility
d. Low permeability, low solubility

A

B

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8
Q

Pharmaceutically equivalent drugs have the:
I. Same active ingredient
II. Same dosage form
III. Same salt or ester
a. I and II
b. II and III
c. I and III
d. I, II, III

A

D

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9
Q

What happens to the half-life if the drug clearance is
reduced by 50%?
a. Half-life will be doubled
b. Half-life will decrease by 50%
c. Half-life will decrease four-fold
d. There will be no effect on half-life.

A

A

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10
Q

Active transport moves against the concentration
gradient. Therefore, it does not consume energy.
a. Only the first statement is correct.
b. Only the second statement is correct.
c. Both statements are correct.
d. Both statements are incorrect.

A

A

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11
Q

The aqueous solubility of a weak-base drug is poor.
Which of the following would be the correct strategy to
improve drug absorption from the intestinal tract?
a. Give the drug as a suspension and recommend
that the suspension be taken on an empty
stomach
b. Give the drug as a hydrochloride salt
c. Give the drug with milk
d. Give the drug as a suppository

A

B

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12
Q

The goal of drug metabolism is to:
I. Convert a drug to a more polar metabolite to be
excreted
II. Convert a drug to a more non-polar metabolite to
be excreted
III. Convert a drug to a more water-soluble drug to
be excreted
IV. Convert a drug to a more lipid-soluble drug to be
excreted
a. I and III
b. II and IV
c. II and III
d. I and IV

A

A

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13
Q

What is the correct order of bioavailability for different
dosage forms?
a. Solutions > Emulsion > Capsules > Tablet > SR
Tablet
b. Solutions > Emulsion > Tablet > Capsules > SR
Tablet
c. Emulsion > Solutions > Tablet > Capsules > SR
Tablet
d. Emulsion > Solutions > Capsules > Tablet > SR
Tablet

A

A

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14
Q

What is the primary mechanism of drug absorption through
the rectal route?
a. Endocytosis
b. Facilitated diffusion
c. Passive diffusion
d. Pore transport

A

C

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15
Q

Which of the following factors is most likely to lead to a
decrease in bioavailability of a drug?
a. Decreased gastric pH
b. Inhibition of drug metabolism
c. Enhanced efflux transporters in the gastrointestinal
tract
d. Increased intestinal blood flow

A

C

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16
Q

Which equation describes the rate of drug dissolution from
a tablet?
a. Fick’s law
b. Henderson-Hasselbach equation
c. Law of mass action
d. Michaelis-Menten equation
e. Noyes-Whitney equation

A

E

17
Q

The rate-limitng step in the bioavailability of a lipid soluble
drug formulated as an immediate-release compressed tablet
is the rate of
a. Disintegration of the tablet and release of the drug
b. Biotransformation of the drug by the liver before
systemic absorption occurs
c. Transport of the drug molecules across the intestinal
mucosal cells
d. Dissolution of the drug
e. Blood flow of the gastrointestinal tract

A

A

18
Q

What is the order of reaction in which the concentration of
a drug is decreasing at a rate that is proportional for the
concentration of the drug remaining?
a. Zero order
b. First order
c. Second order
d. Third order

A

B

19
Q

As per FDA proposal, biowaiver is applicable for what BCS
category?
I. Class I
II. Class II
III. Class III
IV. Class IV
a. I and II
b. II and IV
c. I and III
d. III and IV
e. I, II, and III

A

C

20
Q

Which of the following is true about pharmaceutical
equivalents
I. Same active ingredient
II. Same dosage form
III. Same dosage strength
IV. Different route of administration
a. I and II
b. II and IV
c. I and III
d. III and IV
e. I, II, and III

A

E

21
Q

The following are TRUE regarding patients with renal
impairment, EXCEPT:
a. They have reduced requirement for drugs that are
directly excreted by the kidneys.
b. The elimination of renally cleared drugs is increased.
c. Adjustments can be done by prolonging dose
intervals
d. The serum creatinine levels are higher than the
reference value

A

B

22
Q

Which of the following describes the action of Protamine
against Heparin?
a. Physiologic antagonism
b. Competitive antagonism
c. Irreversible antagonism
d. Chemical antagonism

A

D

23
Q

Which of the following is the term used to describe the
elimination rate via metabolism catalyzed by alcohol
dehydrogenase when the enzyme is saturated?
a. Second-order kinetics
b. Zero-order kinetics
c. First-order elimination
d. Clearance

A

B

24
Q

Zero-order kinetics EXCEPT:
I. Ethanol
II. Warfarin
III. Phenytoin
IV. Aspirin
a. I and III
b. II and IV
c. All of the above
d. None of the above

A

D

25
Q

Isoniazid undergoes what type of conjugation reaction?
a. Glycine conjugation
b. Glutathione conjugation
c. Acetylation
d. Sulfation

A

C

26
Q

Which of the following would be the implication if the drug
has an increased clearance in a patient?
a. A lower dose is needed to achieve the target
concentration
b. A higher dose is needed to achieve the target
concentration
c. A faster administration rate is needed to achieve the
target concentration
d. A slower administration rate is needed to achieve the
target concentration

A

B

27
Q

Gastric emptying rate is slowed down by the ff: except:
a. Heavy meals
b. Vigorous exercise
c. Lying on the left side
d. Hunger

A

D

28
Q

True for all drug products administered by all routes except
IV:
a. Liberation
b. Metabolism
c. Absorption
d. Excretion

A

A

29
Q

The volume of distribution of a particular drug will be
a. Independent of tissue concentration
b. Approximately the same for all drugs in a given
individual
c. Greater for drugs that concentrate in the tissues
rather than in plasma
d. Independent of plasma concentration

A

C

30
Q

Which of the following drugs do not bind to plasma protein
to any significant extent
a. Amitriptyline
b. Diazepam
c. Lithium
d. AOTA

A

C

BIOPHARM (1 decks)

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