Bladder Biopsies - Molavi

Question 1

Answer 1

von Brunn’s nest

Very common in the bladder

When columnar cell metaplasia appears in the lumen, as seen here, it is referred to as “cystitis glandularis”

Question 2

Answer 2

Granulomatous cystitis

Generally indicates one of three things:
1. Mycobacterium tuberculosis
2. Post-BCG topical therapy for urothelial carcinoma (remember, BCG activates trained immunity)
3. Schistosomiasis (Hx of travel, bladder wall will contains purple fragments of eggs)

Question 3

Answer 3

Schistosomiasis

You can see the eggs in this biopsy