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Block 6 Exam 1 > BLI 6 - Microcytic Anemia (Siddiqui) > Flashcards

BLI 6 - Microcytic Anemia (Siddiqui) Flashcards

(53 cards)

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1
Q

Increase in HbF

A

beta-thal major

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2
Q

Clinical manifestations of lead poisoning

A

L: Lead lines on gingivae & metaphyses of long bones

E: Encephalopathy, Erythrocyte basophilic stippling

A: Abdominal colic, sideroblastic Anemia

D: Drops - wrist and foot drop, Dimercaprol and EDTA 1st line of tx

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3
Q

Koilonychia (spoon nails)

A

iron deficiency anemia

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4
Q

whole gene deletions, asymptomatic, mild microcytic anemia

A

alpha-thal minor

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5
Q

Alcohol poisons mitochondria B6 deficiency due to isoniazid

A

Acquired sideroblastic anemia

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6
Q

thalassemia - africans

A

Trans-deletion

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7
Q

EPO - down

Hepcidin - up

A

ACD

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8
Q

Labs for iron deficiency anemia:

  • Serum iron
  • %sat -Serum ferritin
  • FEP (free erythrocyte protoporphyrin)
  • sTfR (soluble transferrin receptor) - TIBC
A

Serum iron - down

TIBC - up

%sat - down

FEP - up

Serum ferritin - down

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9
Q

Lab results for ACD:

  • Serum iron
  • Serum ferritin
  • %sat -sTfR (TIBC)
  • FEP
A

Serum iron - N to down

Serum ferritin - up

%sat - N to down

sTfR - down (always opposite ferritin)

FEP - up

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10
Q

Incompatible with life – Hydrops fetalis

A

Hb Barts (homozygous alpha-thal)

  • “all 4” alpha mutated
  • excess gamma forms tetramers
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11
Q

whole gene deletions, symptomatic, hemolytic and microcytic anemia, splenomegaly

A

Hb H Disease (alpha-thal)

  • transfusion dependent
  • “3 of 4 alpha” mutated
  • excess beta globin forms tetramers = Hb H
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12
Q

Koilonychia Pallor of skin/face Conjunctival pallor Palmar pallor Atrophic glossitis

A

IDA

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13
Q

Lab results for sideroblastic anemia:

  • Serum iron
  • TIBC/sTfR
  • %sat
  • Serum ferritin
A

Serum iron - up (accumulates as ring sideroblasts)

TIBC/sTfR - down

%sat - up

Serum ferritin - up

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14
Q

Iron sequestered in macrophages

A

Chronic inflammation

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15
Q

Mutation in ALAS

A

Sideroblastic anemia

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16
Q

Menstruation Childbirth GI disease

A

IDA - chronic blood loss

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17
Q

IDA + Esophageal webs + atrophic glossitis

A

Plummer-Vinson syndrome

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18
Q

Increase in Hb A2

A

beta-thal minor

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19
Q

X-linked

A

Sideroblastic anemia

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20
Q

Lead poisoning

A

Acquired sideroblastic anemia

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21
Q

RA, SLE, IBD, cancer

Increased hepcidin

A

ACD

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22
Q

Massive erythroid hyperplasia

23
Q

Childhood

Pregnancy

Study These Flashcards
A

IDA - increased requirement

24
Q

Lab value that is high when TIBC is low

Study These Flashcards
A

Ferritin - iron storage

25
thalassemia - asians
Cis-deletion - LETHAL risk in offspring
26
Sprue Gastric bypass
IDA - malabsorption
27
\_\_\_\_\_, ______ anemia with target cells and nucleated RBC's is seen with thalassemia
Microcytic, hypochromic
28
mild disease due to point mutation, asymptomatic
beta-thal minor
29
Iron deficiency blood smear: -MCV -MCHC -RDW
MCV - down MCHC - down RDW - up
30
Iron deficiency anemia begins as \_\_\_\_\_\_, ______ anemia
normocytic, normochromic
31
whole gene deletions
alpha-thalassemia
32
crewcut appearance
Thalassemia
33
Excess alpha chains dimerize with delta (Hg A2) - isolated increase
beta-thal minor
34
Elevated HbA2 or HbF
Beta-thalassemia
35
inhibits iron transport
hepcidin
36
Lab value that is high when ferritin is low
TIBC - indirect measurement of transferrin
37
how do you calculate % saturation
serum iron / TIBC
38
Asian Middle Eastern Mediterranean (Italian-American)
Thalassemia
39
alpha genes
4 alpha genes chromosome 16
40
beta genes
2 beta genes chromosome 11
41
Lead chelation for kids
Succimer
42
Decreased overall iron
Fe deficiency
43
Breast fed infants Elderly Pregnant women
IDA - inadequate diet
44
severe anemia becomes symptomatic after 6 months of age, transfusion-dependent
beta-thal major absent Hb A production, only Hb F production (protective at birth)
45
Lab values seen when you suspect increased hepcidin
Increased ferritin Decreased TIBC
46
binds ferroportin
hepcidin
47
Decreased protoporphyrin synthesis
Sideroblastic anemia
48
Absent or markedly decreased Hb A Hb F increased and alpha tetramers precipitate
beta-thal major
49
point mutations
beta-thalassemia
50
Inhibits ALAD and Ferrochelatase
Lead poisoning
51
Thalassema: - MCV \_\_\_\_\_\_\_
MCV 5 x 10^12/ L
52
Decreased globin chain synthesis
Thalassemias
53
pica - craving clay, ice chips, etc
iron deficiency anemia

Block 6 Exam 1 (8 decks)

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