Block 11 Flashcards

(385 cards)

1
Q

What is leukemia

A

Cancer of the WBCs/blood/bone marrow

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2
Q

What is leukocytosis

A

Increase in the total WBC count

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3
Q

What is neutrophilia

A

Increase in the neutrophil count

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4
Q

What is lymphocytosis

A

Increase in lymphocyte count

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5
Q

What is leukopenia

A

Decrease in the total leukocyte count

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6
Q

What is neutropenia

A

Decrease in neutrophil count

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7
Q

Lymphocytopenia

A

Decrease in lymphocyte count

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8
Q

What is pancytopenia

A

All blood lineages are decreased

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9
Q

What is the leukemoid reaction

A
Leukemia like infection 
Neutrophils increase (
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10
Q

T/F leukemoid reaction is a form of leukemia

A

False

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11
Q

What is leukemoid reaction often confuse with

A

Chronic myelocytic leukemia

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12
Q

Who is acute lymphocytic leukemia most common in

A

Children (3-7 yoa)

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13
Q

What are the symptoms of ALL

A
Acute illness
Pale
Bruises easily
Bleeding gums
Infection
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14
Q

What is seen in labs of ALL patients

A

WBC very low or very high

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15
Q

What is diagnostic of ALL

A

Tdt

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16
Q

What is the prognosis for people diagnosed with ALL

A

Good prognosis

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17
Q

Who is most commonly affected with Acute myeloid leukemia (AML)

A

Adults (approx 55 yoa)

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18
Q

What are the symptoms of AML

A
Acute illness
Pale
Bruises easily
Bleeding gums
Infection
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19
Q

What is seen in labs for AML

A

> 20% blasts in bone marrow

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20
Q

What is diagnostic of AML

A

Auer rods

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21
Q

What is the prognosis of AML

A

Poor prognosis

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22
Q

Who is most commonly affected by chronic myeloid leukemia (CML)

A

Adults (age 50)

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23
Q

What are the symptoms of CML

A

They are usually asymptomatic

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24
Q

What is usually seen in labs for CML patients

A

High WBCs

Immature/mature neutrophils

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25
What is diagnostic of CML
Philadelphia chromosome
26
What drug has been used and increased the survival of CML
Gleevec | >80% remission
27
What is the most common leukemia
Chronic lymphocytic leukemia (CLL)
28
Who is usually affected by CLL
Adults (>50 yoa)
29
What is seen in labs for CLL
Increase WBCs (>20K)
30
How is CLL found
Usually found by accident at a physical
31
What is the survival of CLL
10 year survival for types 1 and 2 | <2 year survival for types 3 and 4
32
T/F you probably wont kill CLL
True
33
How do you treat CLL
You normally don't treat it
34
What is diagnostic of Hodgkins Lymphoma
Reed-Sternberg cells
35
What is the survival of Hodgkins Lymphoma
85% survival
36
What is non-Hodgkins Lymphoma survival
69% survival
37
What is Lymphoma stage 1
Single lymph node affected
38
What is lymphoma type 2
2 or more lymph nodes on one side of diaphragm
39
What is lymphoma type 3
Cancer spreads to both sides of diaphragm or involves spleen
40
What is lymphoma stage 4
Liver, bone marrow, lung
41
What is the hemoglobin rule of 3
Hemoglobin x3= hematocrit +/-3
42
How do you find hemoglobin from hematocrit
Hematocrit /3 : hemoglobin
43
What is the size of RBC comparable to
The size of lymphocytic nucleus
44
What is anemia
HGB and HCT are both low
45
What are the 3 causes of anemia
Blood loss Impaired RBC production Accelerated RBC destruction
46
What is hypochromic
Low MCHC
47
What is hyperchromic
High MCHC
48
What is microcytic anemia
MCV<75
49
What are the 1st and 2nd most common of microcytic anemia
1. Iron deficiency | 2. Thalassemia
50
What is normacytic anemia
MCV 80-98
51
What is macrocytic anemia
MCV>100 `
52
What are the common forms of macrocytic anemia
B12/folate deficiency
53
How much B12 is stored
3 years worth
54
How much folate is stored
3 months
55
What vegetable can cause hemolytic anemia
Fava beans
56
What drugs can cause hemolytic anemia
NSAIDs Sulfa drugs Anti-malarial drugs
57
What is hemolytic anemia associated with
G6PD deficiency | Sickle cell anemia
58
What does G6PD and sickle cell anemia protect against
Malaria
59
Where is thalassemia common
Mediterranean (Italy/Greece)
60
What is thalassemia confused with
Microcytic hypochromic anemia
61
How does thalessemia appear for RDW
Normal
62
The conducting unit of the respiratory system
``` Nasal cavity Nasopharynx Larynx Trachea Bronchi Bronchioles Terminal bronchioles ```
63
What is the respiratory unit of the respiratory system
Respiratory bronchioles Alveolrar ducts Alveoli
64
What is obstructive
Airway conduction is compromised (bronchitis, asthma
65
What is restrictive
Lung expansion is compromised (fibrosis)
66
Sinusitis
Inflammation of the mucous membranes of the paranasal sinuses
67
Sinusitis in adults
Maxillary sinus
68
Sinusitis in children
Ethmoid sinus
69
What are som causes of sinusitis
Upper respiratory infection (bacterial or viral) Deviated nasal septum Smoking
70
What pathogen is mostly associated with sinusitis
Streptococcus pneumoniae
71
What are the symptoms of sinusitis
Pain over sinus Nasal congestion Fever Cough
72
How do you diagnose sinusitis
X ray | CT
73
T/F sinusitis can affect the eye
True It can spread to the orbit and cause sinusitis
74
What is laryngitis
Inflammation of the larynx
75
What is a common cause of laryngitis
Viral (most common) or bacterial
76
What are the symptoms of laryngitis
Coarse voice Fever Heals within days
77
What are 2 important types of laryngitis
Croup | And diphtheria
78
What is croup
Barking cough | Children
79
What is diphtheria
Rare Suffocation Death
80
What is pharyngitis? Symptoms? Test?
Strep threat With pain, adenopathy, NO cough Rapid Strep test
81
What is tracheitis and bronchitis?
Inflammation of the trachea and he bronchi
82
What is pneumonia
Inflammation of the lungs
83
What is typical pneumonia caused by?
Bacterial | Streptococcus pneumoniae
84
What is bronchopneumonia
Begins as acute bronchitis and spreads to the lungs | The lower lobes or right middle lobe is usually affected
85
What is lobar pneumonia What are the complications?
Complete consolidation of a lobe of the lung Lung abscess, emphysema, sepsis
86
What are the clinical findings of pneumonia
Sudden onset of high fever Productive cough Chest pain Tachycardia
87
How do you diagnose pneumonia
Chest X-ray | Lab tests
88
What is atypical pneumonia? | What causes it
In young individuals Mycoplasma pneumoniae (viruses_
89
What are the clinical findings of atypical pneumonia
``` Asking pneumonia Low grade fever Nonproductive cough Chest pain Flu-like symptoms ```
90
What is tuberculosis caused by
Inhalation of mycobacterium tuberculosis
91
Where does the Bacteria for TB reside
In the phagosomes of alveolar macrophages
92
How do you screen for TB
PPD skin test
93
What is primary TB`
``` Can be symptomatic or asymptomatic Upper part of lower lobe Lower part of upper lobe Caseus necrosis in periphery and hilar lymph nodes Usually resolves ```
94
What s secondary TB
Reactivation of previous TB infection Cytokines from memory T cells released Severe Can spread out of lungs
95
What are the clinical findings of TB
Fever Drenching night sweats Weight loss
96
What are the complications of TB
Can spread in lungs, can spread out of lungs Kidneys can be affected Spread to vertebrae, meninges, etc
97
What does introcular TB usually infect
Uveal tract
98
Anterior intraocular TB
Granulmatous keratic precipitates Iris granulomas Cataracts
99
Posterior intraocular TB
Most common | Can mimic tumor
100
Retinal TB
Uncommon Exudative hemorrhagic lesions Scars can form
101
TB of external eye
Affects orbit, eyelid, lacrimal gland, conjunctiva, sclera
102
What is influenza caused by
Influenza virus A and B
103
What can complicate influenza infection
Staphylococcus aureus
104
What are the symptoms of influenza
High fever, joint pain, malaise, pain with eye movements
105
Antigen drift:
Mild mutation, no new vaccine needed
106
Antigen shift:
Major mutation, new vaccine needed
107
What is COPD? Common cause? 2 conditions?
Progressive irreversible obstruction of airflow out of the lungs Smoking Emphysema and chronic bronchitis
108
What is emphysema
Enlargement of all or part of the respiratory unit
109
What is the most common cause of emphysema?
Smoking AAT deficiency
110
What is the pathogenisis of emphysema
``` Increase compliance Decreased elasticity Destruction of elastic tissue Loss of radio traction Small airways collapse on expiration ```
111
What is chronic bronchitis Common cause?
Productive cough that lasts for 3 months for 2 years Smoking
112
What is the pathogenesis of chronic bronchitis
Hyper-secretion of mucus in the bronchi Obstruction of the airlift Irreversible fibrosis
113
What are the clinical findings of the chronic bronchitis
Productive cough Dispnea Hypoemia Large horizontally oriented heart
114
What is bronchial asthma
Epidemic reversible disease of the bronchi Thick bronchial basement membrane Dyspnea with episodic expiratory wheezing Nocturnal cough
115
What is asthma
Type 1 HS rxn to extrinsic allergens Runs in families Initial: CD4, IL4 2nd exposure: IgE, release histamine, Bronchoconstriction, mucus production, influx of leukocytes
116
What is the most common cardiovascular cause of death after acute myocardial infarction and stroke
Pulmonary thromboembolism
117
Where do the majority of pulmonary thromboemboli originate from
Deep veins of the lower extremities and pelvis
118
What are the risk factors for PE
``` Prolonged bed rest Hypercoagulable states (dense blood) ```
119
Large emboli occlude....
Main pulmonary arteries
120
Small emboli occlude....
Medium-sized and small pulmonary arteries
121
What are the consequences of pulmonary artery occlusion
- Increase in pulmonary artery pressure - decrease blood flow to pulmonary parenchyma - hemorrhagic infarction - perfusion is greater than ventilation in the lower lobes - majority are located in the lower lobes
122
What are the clinical findings of PE
``` Saddle embolus: sudden death Sudden onset of dyspnea and tachypnea Pleuritic chest pain Fever Expiratory wheezing ```
123
How do you diagnose PE
Spiral CT Abnormal perfusion radionuclide scan Positive d-dimers-non-specific
124
What is pulmonary hypertension?
Mean PAP>25 mmHG at rest | Mean PAP>30 mmHG with exercise
125
What is primary PH
Cause is not known More common in women Genetic predisposition
126
What is secondary PH
Comorbid condition causes the HTN
127
What are the 2 ways that secondary PH occurs
1. Endothelial cell dysfunction, loss of vasodilator, increase in vasoconstrictors 2. Hypoxemia and respiratory acidosis stimulate vasoconstriction of pulmonary arteries , smooth muscle hypertrophic and hyperplasia
128
What is for pulmonale
Combination of PH and RVH leading to right sided heart failure
129
What are some causes of Cor pulmonale
``` Chronic hypoxemia Chronic respiratory acidosis Chronic bronchitis Emphysema Volume overloading pulmonary vasculature Left sided vasculature disease Backup of blood into pulmonary veins ```
130
What are teh pathologic findings with Cor pulmonale
Atherosclerosis of main elastic pulmonary arteries smooth muscle hypertrophy
131
What is pulmonary edema
Excess fluid in the lungs | Fluid collects in the air sacs and makes it difficult to breathe
132
What usually causes pulmonary edema
Heart problems
133
What are the 2 mechanisms of pulmonary edema
1. Increased hydrostatic pressure in lung capillaries - left sided heart failure, volume overload, mitral stenosis 2. Decreased oncotic pressure
134
What are some things that can cause pulmonary edema
Infections Aspiration Drugs High altitude
135
What is chronic interstitial lung disease
Fibrosing disorders | Granulomatous disease
136
What is the pathogenesis of interstitial fibrosis
Early: alveolitis | Leukocytes release cytokines, that stimulate fibrosis
137
What are the effects of interstitial fibrosis
Decreases lung compliance (decreased expansion) Increases lung elasticity (stiffness)
138
What are the clinical findings of interstitial lung disease
Dry cough Exerting dyspnea Potential for Cor pulmonale
139
Who is most affected by idiopathic pulmonary fibrosis
Smoking males | 40-70 yoa
140
What is the pathogenesis of idiopathic pulmonary fibrosis
Repeated alveolitis Release of cytokines produces interstitial fibrosis Proximal dilation of small airways Lung has honey comb appearance
141
How does the Lung appear in idiopathic pulmonary fibrosis
Honeycomb
142
What are the clinical findings of idiopathic pulmonary fibrosis
Fever Progressing dyspnea with exertion Chronic nonproductive cough Late inspiratory cackle
143
What is pneumoconioses
Inhalation of mineral dust not the lungs leading to interstitial fibrosis Mineral dust includes coal dust, silica, asbestos, and beryllium
144
Particles >5um are captured by
Large bronchi and eliminated by coughing
145
Particles >0.5um...
Reach the alveoli and are phagocytosed by alveolar macrophages
146
Particles 1-5 um...
Get stuck at the bifurcation or bronchioles/alveolar ducts
147
What is the least fibrogenetic particle
Coal dust
148
What substances are very fibrogenic
Silica Asbestos Beryllium
149
What is anthracosis
Coal workers pneumoconiosis Usually asymptomatic Pigment in interstitial tissue and hilar nodes
150
What is simple coal workers pneumoconiosis
Fibrotic opacities are smaller than 1 cm in upper lobes and upper portions of lower lobes
151
What is complicated wool workers pneumoconiosis
Fibrotic opacities larger than 1-2cm IR without necrotic centers Crippling lung disease (black lung)
152
What is sarcoidosis
Multi-system noninfectious granulomatous disease that produces chronic interstitial fibrosis
153
Who is affected most commonly by sarcoidosis
Black Non smokers Women 20-39 years old
154
What is the pathogenesis of sarcoidosis
Disorder in immune regulation
155
What must you rule out when diagnosing sarcoidosis
Granulomatous disease
156
What is the primary target of sarcoidosis
Lung
157
What is the most common symptom of sarcoidosis
Dyspnea
158
What are the skin lesions with sarcoidosis
Modular lesions containing granulomas
159
What are eye lesions with sarcoidosis
Uveitis
160
What s seen in lab tests for sarcoidosis
Increase ACE
161
How is sarcoidosis treated
It is not really treated unless required (steroids) | It usually resolves on its own in 3 years
162
What is the most common fatal cancer in both mean and women worldwide
Primary lung cancer
163
What are some causes of lung cancer
``` Smoking Risk increases with quantity and duration of smoking Men have a greater risk Asbestos Certain metals Secondhand smoke ```
164
What are some classification of primary lung cancer?
``` Adenocarcinoma Squamous cell carcinoma Small cell lung carcinoma Large cell carcinoma Bronchial carcinoid ``` Small cell and non-small cell
165
What is small cell lung cancer prognosis
Very malignant
166
What is non-small cell carcinoma prognosis
Better | Longer life expectancy
167
Where are the common sites for metastasis
``` Hilar lymph nodes * most common Adrenal gland Liver Brain Bone ```
168
What are teh molecular genetics of lung cancer
Gene mutations ``` Oncogenes (promote cell survival and division) Suppression genes (promote cell apoptosis) p53 ```
169
What are the clinical findings in primary lunch cancer
``` Cough Weight loss Hemoptysis Dyspnea Chest pain ```
170
What is adenocarcinoma
Peripheral tumor Most common In non-smokers, women Grows slowly but metastasizes early Scar carcinoma develop in scars
171
What is squamous cell carcinoma
Central More common in men Strong association with smoking P52 mutations
172
What is pancoast tumor
Lung carcinoma in the apex o lungs
173
What Can a pancoast tumor cause
Horners syndrome
174
What is the triad of Horner's syndrome
Ptosis Mitosis Anhidrosis Compression of the superior sympathetic ganglia
175
What is pneumothorax
Air in thoracic cavity
176
What is hemothorax
Blood in thoracic cavity
177
What is atelectasis
Loss of lung volume caused by collapse of alveoli | Results in shunting of inadequate oxygenated blood from pulmonary arteries to veins
178
What is disruptive sleep apnea
Excessive snoring with intervals of breath cessation
179
What are some causes of sleep apnea
Obesity (the pharyngeal muscles collapse)
180
What is the pathogenesis of sleep apnea
Airway obstruction causes CO2 retention and hypoxemia
181
What is the cardiovascular systems job
To maintain sufficient blood pressure to profuse the body
182
T/F the body will alter Hr, contractility, and vessel diameter, CO, peripheral resistance and blood volume to maintain MAP
True
183
What is teh leading cause of death in the US
Cardiovascular disease
184
What are the most common CVDs?
Hypertension | Coronary artery disease
185
What doe CVD risks increases with
Age and lifestyle choices
186
What is high BP
14-/90
187
What is normal BP
120/80
188
What is primary HTN
Don't know the cause
189
What is secondary HTN
Due to another disease/drug | Can resolve with cause
190
What can prolonged HTN cause
Damage to vessel walls | Arteriosclerosis, atherosclerosis, stroke, CAD
191
What are the risk factors of HTN
Cardiac hypertrophy Heart failure Retinal exudates Flame and hemorrhages
192
What does injury to vessel wall cause
Remodeling | It is normal with aging
193
What can excessive vessel remodeling lead to
Arteriosclerosis | Atherosclerosis
194
What is hyaline arteriosclerosis
Aging process accelerated by hypertension In less sever HTN Increased ECM narrows artery ad reduces compliance
195
What is hyperplastic arteriosclerosis
In severe HTN New smooth muscle cells (onion) Narrows vessel, reduces compliance and causes vessel necrosis
196
What is atherosclerosis
Prescence of plaques in arteries Weakens the vessel If it ruptures it can cause a clot Clot can break off and lodge elsewhere
197
What are some of the treatments for HTN
``` Lifestyle changes BB, CCB Diuretics ACEI, ARBs Cholesterol lowering medications ```
198
What are some causes of heart disease
``` Failure of pump Obstruction of flow Regurgitant flow Flow disorders Conduction disorders ```
199
When do pump failures occur
When the heart cannot maintain cardiac output or can only maintain it at altered filling pressures
200
What is systolic heart failure
Heart cannot generate sufficient force Due to ischemia or HTN
201
What is diastolic heart failure
Heart cannot properly relax Due to HTN, fibrosis, or pericarditis
202
What is myocardial ischemia
A heart attack Lack of sufficient blood flow to the heart
203
What can cause a MI
Reduced blood flow to overworked muscle Clot in the coronary circulation
204
What is the result of MI
Loss of heart muscle and production of non-contractile scar
205
What usually proceeds heart failure
Periods of angina, dyspnea, and confusion | As heart muscle dies, biomarkers are released and can be examined
206
What is the only treatment for MI
Restore blood flow by stent or bypass
207
What is left sided heart failure
The left ventricle is the cause of failure The left side cant pump what the right side gives it, so volume builds up in the lung Increased volume increases pressure and causes pulmonary edema Increases workload on the heart
208
What is right sided heart failure
The right ventricle is the cause Right side cant pump what the left gives it, volume builds up the periphery Edema in the liver and legs Increases workload on the left side
209
How do you treat heart failure
Reduce workload of heart (B.B., CCB, diuretics) Increase contractility to increase CO nad maintain fxn (B Ag, cardiac glycosides) Heart transplant in only cure
210
What are some things that cause flow abnormalities
Flow obstruction Regurgitant flow Disordered flow
211
What is an obstructive flow
Stenotic valves of hypertension increase pressure required to move blood Can lead to hypertrophy and fibrosis
212
What is regurgitant flow
Valves do not close properly, increase volume moving backwards Leads to dilation of the heart
213
What is disordered flow
Vessel abnormalities reduce flow to the periphery Aneurysms, coarted arota, patent ductus arteriosis
214
What is the treatment for Flow abnormalities
Fix the reason for altered flow Surgery Replace old valves Have to be replaced every couple of decades
215
What are som conduction abnormalities
Arrhythmia
216
What is an arrhythmia
Damage to the conduction system of the heart that causes altered conduction pathways and irregular heart beats
217
What is the most dangerous arrhythmia
Ventricular arrythmia
218
What is the most common arrythmia
Atrial fibrillation
219
What is atrial fibrillation
Non-contracting atria Has little affect on the heart Atria only matter at high heart rates or in late heart failure Causes pooling of blood, clots can form on walls
220
What must you pull all afib patients on
Anti-coagulant
221
What are some examples of endocrine disorders
``` Diabetes Thyroid diseases Parathyroid diseases Pituitary disorders Adrenal dysfunctions ```
222
What is insulin released by
B cells of the pancreas
223
What is insulin made up of
A,B,C chains | The C chain is removed during production and secreted with insulin
224
How is insulin secretion regulated
1. Insulin is secreted when blood glucose is high 2. GLUT2 transports glucose into B cells 3. Glucose is oxidized to produce ATP 4. high ATP levels cause closure of ATP sensitive K channels 5. Less K leaving the cell causes depolarization 6. Depolarization opens Ca channels 7. Ca causes exocytosis of insulin into the blood stream
225
What is the MOA of insulin
Binds its receptor (receptor tyrosine kinase) Receptors phosphorylate themselves and become active They phosphorylate other proteins inside the cell (IRS-1 and GLUT 4) Receptor is then internalized and destroyed/recycled
226
What are the major actions of insulin
- storage of excess energy - decrease blood glucose levels - decreases blood fat levels - decreases blood A.A levels
227
What is diabetes mellitus
Group of diseases with a common presentation of hyperglycemia
228
What is normal fasting glucose
70-100
229
What is pre-diabetic glucose levels
100-125
230
What is diabetes glucose levels
<125
231
What is insulin dependents diabetes
10% Type 1/juvenile Autoimmune destruction of B cells -no insulin is produced -increases blood levels of glucose, lipids, and proteins Muscle wasting Diabetic ketoacidosis due to use of fats as energy. Diuresis, acidosis, hyperkalemia
232
What is the treatment for insulin dependent diabetes
Lifelong insulin therapy
233
What is non insulin dependent diabetes
90% Type 2/adult onset Loss of insulin sensitivity due to chronic high levels of BG Make insulin but we don’t respond to it
234
What are the treatments for non-insulin dependent diabetes
``` Life style changes Metformin Sulfonylureas Thiazolidinedione SGLT2 inhibitors ```
235
What is the HPT axis
Production of T3/T4 Hypothalamus releases TRH Ant. Pit releases TSH Thyroid releases T4 and T3
236
What thyroid hormone is more potent
T3
237
What thyroid hormone is more produced
T4
238
What makes T3/T4 master metabolic hormones
Signals through a steroid pathway Bone growth and maturation CNS maturation Increases BMR and heat production Increases all body metabolisms Increases cardiac output
239
How does T3/T4 work
It’s a peptide hormone that acts like a steroid Intracellular receptor Directly initiates transcriptional changes
240
What is hyperthyroidism
Too much T/3T4 (Graves)
241
What are the symptoms of Graves
``` Weight loss Increased appetite Heat intolerance Sweating Increased cardiac output Exopthalmos Goiter ```
242
How is graves diagnosed
Serum TSH and T/T4 levels
243
What is the treatment for hyperthyroidism
Remove thyroid/tumor
244
What is hypothyroidism
Not enough T3/T4 Hashimotos Iodine deficiency Ceongenital
245
What are the symptoms of hypothyroidism
``` Weight gain Cold intolerance Low cardiac output Mental slowness Lack of energy Myxedema(swollen puffy skin) ```
246
How do you diagnose myxedema
Serum TSH
247
How do you treat hypothyroidism
Give them exogenous T3/T4 or iodine
248
What is ceongental
Cretinism T3/T4 is needed for development Physical and mental develop abnormalities Learning disabilities Growth inhibited Protruding tongue Umbilical hernia
249
What is Hashimoto’s thyroiditis
Autoimmune destruction of the thyroid gland Old women First sign is goiter Anti-thyroid antibodies Inflammation and cell death in the thyroid
250
What is a goiter
Enlarged thyroid Caused by low iodine Can occur in hyper/hypothyroidism Can lead to thyroid tumors
251
What do the parathyroid glands release
PTH from chief cells
252
What does PTH respond to
Serum ionized calcium levels Released in repsonse to low levels Works to raise blood calcium levels
253
What are the actions of PTH
Works on kidney to increase phosphate excretion and calcium reabsorption - increase osteoclasts activity - activates VitD to allow for better absorption of dietary Calcium
254
What is primary hyperparathyroidism
Due to parathyroid tumor
255
What are the symptoms of primary hyperparathyroidism
``` Hypercalcemia Weakened bones Hypophosphatemia Renal stones block ureter Constipation Depression ```
256
How do you treat primary parahyperthyroidism
Remove tumor
257
What is secondary hyperparathyroidism
Due to renal failure VitD must be activated in the kidney Hypocalcemia due to dietary absorption which increases PTH levels Bones are dissolved and serum calcium is restored Weakened bones Possible calcifications of some vessels
258
What is hypoparathyroidism
A rare condition Due to thyroid removal Congenital abnormality Autoimmune destruction of parathyroid glands
259
What are the symptoms of hypoparathyroidism
``` Hypocalcemia Hyperphosphatemia Muscle spasms Tetany Cardiac arrhythmias Increases intracranial pressure Seizures Clotting disorder ```
260
What does the anterior pituitary release a lot of
Stimulating hormones And GH’s
261
What is hypopituitarism due to
Non functioning tumor Congenital Ischemia Radiation damage
262
What can hypopituitarism result in
Slow loss of most downstream glandular function FSH/LH lost first GH 2nd lost Thyroid/ACTH last to go
263
What is hyperpituitarism due to
Tumor in pituitary gland
264
What are the tumors in hyperpituitarism composed of
One cell type | Will produce too much of only one hormone
265
T/F GH doesn’t have a downstream gland
True, its special
266
What is the MOA of growth hormone
-GH binds receptor and causes phosphorylation of intracellular proteins -regulates blood levels of all energy sources -causes protein synthesis and organ growth -linear bone growth =produces somatomedins that act like GH in some targets
267
What causes GH deficiency
Pituitary damage
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What occurs in GH deficiency in Newborns (congenital)
Failure to grow and develop normally in first months Must give GH to allow catchup
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What occurs in GH deficiency in children (acquired)
``` Short (dwarfism if not corrected) Under developed Poor bone density Low muscle mass Late puberty ```
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What occurs in GH deficiency in Adults (acquired)
Loss of lean muscle Obesity Poor bone density Increased risk of cardiovascular disease
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What normally causes GH excess
Tumor
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What occurs in GH excess in newborns and children
- Pituitary gigantism - Rare - Increased linear growth - early mortality due to overgrowth of organs - predisposition to diabetes, HTN, osteoporosis
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What occurs in GH excess in adults
``` Acromegaly Due to pituitary tumor Growth of all soft tissues and organs Cardiovascular issues Long fingers No gain in height Insulin resistance Peripheral vision loss ```
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What do the adrenal glands produce
Glucocorticoids NE Epi mineralcorticoids (aldosterone)
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What is cortisol
Stress hormone
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What affects does cortisol have
- Increases protein catabolism - increase fatty acid usage - maintenance of blood glucose levels - stimulates gluconeogensis by liver - anti-inflammatory and immunosuppression
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What is hypercortisolism usually caused by
Taking Glucocorticoids Too much ACTH or adrenal tumor
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What us Hypercortisolism (Cushings)
``` Adrenal produces too much cortisol Hyperglycemia Weight gain Central obesity Moon face Buffalo hump Muscle wasting HTN Virilization ```
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What is hypocortisolism due to
Autoimmune destruction of adrenal cortex (common after TB)
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What are the symptoms and causes of Hypocortisolism (Addison’s)
Adrenal don’t make enough cortical hormones ``` Hypoglycemia Weight loss Muscle weakness Hypotension Hyperkalemia Metabolic acidosis Hyperpigmentation ```
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What causes hyperpigmentation in Addison’s
Overproduction of ACTH ACTH and MSH come from the are protein Bronze skin and dark organs
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What is pheochromocytoma
Tumors of chromaffin cells Common symptom of HTN Diagnose by imaging serum Epi/NE Treat by removing the tumor
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What is achalasia
Incomplete relaxation of the lower esophageal sphincter in response to swallowing
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What is the physiological sphincter of the esophagus
Lower sphincter
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What is primary achalasia
Mesenteric ganglia that carry the vagal fibers from the esophagus are absent
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What is the danger of achalasia
Aspiration of esophageal content into the lungs
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What can the stasis of food sue to achalasia cause
Inflammation or ulceration
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What is a hiatal hernia
Herniation of the stomach through the esophageal hiatus of the diaphragm
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What is GERD
Reflux or backward movement of gastric contents into the esophagus
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What are some presentation of GERD
Heartburn or pyrosis associated with eating
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What causes GERD
Weak or incompetent lower esophageal sphincter causes GERD
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What are some agents that decrease the one of the esophageal sphincter
``` Food CNS depressants Obesity Preggo Hiatal hernia Delayed gastric emptying Increased gastric volume ```
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How do you treat GERD
``` Avoid positions that cause reflux Avoid large meals Avoid trigger foods Weight loss Drugs (antacids, etc.) ```
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What are the symptoms of GERD
Heart burn 30-60 min after eating that is relieved by sitting upright Wheezing, chronic cough, hoarseness of voice
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What is GERD often confused with
Angina
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Where is the pain with GERD
Epigastric or retrosterna area that radiates to the throat, shoulder, or back
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What is Barrett’s esophagus
Distal esophageal squamous cells replace columnar epithelium containing goblet cells A complication of GERD The inflammation leads to ulceration
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What are the complications of Barrett’s esophagus
Strictures and ulcers
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Why can Barrett’s esophagus form adeocarcinoma
30-40% Because of high grade dysplasia Needs periodic screening
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What are the 2 types of esophageal cancer
Adenocarcinoma | Squamous cell carcinoma
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What is adenocarcinoma complications of
GERD and Barrett esophagus
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Where does adeocarcinoma occur
Distal 1/3 esophagus | (White males)
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Where does squamous cell carcinoma occur
Middle part of esophagus (top 2/3)
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What are the risk factors for squamous cell carcinoma
``` Alcohol Tobacco Injury Achalasia Consumption of hot beverages ```
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What are the common presentations of esophageal cancer
``` Dysphagia** Weight loss Anorexia Fatigue Pain on swallowing ```
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How do you treat esophageal cancer
Depends on the stage Early: surgical resection/radiation/chemo Long term survival is limited
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What is food churned with in the stomach
HCl and pepsin
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What is the gastric mucosal barrier
- Lining that is impermeable to acid it secretes | - there is coupled secretion of H+ ad HCO3- ions
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Gastric mucus is _____
Protective
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Why are cells closely packed in gastric muscular barrier?
To prevent acid penetration and covered with an impermeable hydrophobic layer There is no diffusion of ionized water soluble molecules
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What disrupts the gastric barrier
Aspirin and bile
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What protects the stomach wall
Prostaglandins
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What is gastritis
Inflammation of gastric mucosa
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What are the causes of gastritis
``` Aspirin, alcohol, NSAIDs Bacterial toxins Oral corticosteroids Serious illness/trauma with stress Radiotherapy Chemo ```
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What are some causes of acute gastritis
Spirit Alcohol Toxins (s. Aureus)
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What causes black/tarry stools in acute gastritis
Hemorrhage
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What is chronic gastritis
Presence of chronic inflammation leading to atrophy Absence of grossly visible erosions
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What are the 3 types of chronic gastritis
1. Helicobacter pylori gastritis 2. Autoimmune gastritis 3. Chemical gastropathy
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What resolves acute gastritis
Removal of the cause of it
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What is the most common cause of gastritis in the US
Helicobacter pylori gastritis
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How does H. Pylori cause gastritis
It produces enzymes and toxins leading to inflammation, atrophy, and metaplasia
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Gram stain of H. Pylori
Red
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How do you treat H. Pylori gastritis
2-3 Ab with a Proton pump inhibitor
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What causes autoimmune gastritis
Rare (10%) Autoantibodies to gastric cells and intrinsic factor Causes anemia, atrophy, and adenocarcinoma Chronic injury is due to alkaline duodenal reflux
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What is peptic ulcer disease
Involve gastric muscle and proximal duodenum Can affect one or all 3 layers of the stomach Regeneration is imperfect with scarring
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What are the risk factors for peptic ulcer disease
``` H. Pylori NSAIDs Corticosteroids Smoking Genetics ```
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What are the symptoms o peptic ulcer disease
Epigastric discomfort and pain Periodic pain is the hallmark
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What are teh complications of peptic ulcer disease
Hemorrhage Perforation Gastric outlet obstruction
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How do you treat PUD
Eradicate cause
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What is Zollinger-Ellison Syndrome
Rare condition with irresectable gastronomes in duodenum and pancreas 2/3 are malignant 1/3 have metastasized by time f diagnosis
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What are curling ulcers
Caused by major physiological stress like burns, trauma, sepsis, severe liver failure, major surgical procedures
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What are Cushing ulcers
Gastric, duodenum, and esophageal ulcers in persons with intracranial injury Increased ICP causes vagal stimulation and hypersecretion of acid
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What is the 15th leading cause of death
Stomach cancer
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What are the risk factors fro stomach cancer
Genetics Carcinogens Autoimmune gastritis Gastric adenoids/polyps
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What are the symptoms of stomach cancer
Vague | DETECTION is difficult
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What is the diagnosis for stomach cancer
Ba X ray Endoscopy/biopsy Cytologic studies
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What it’s eh treatment for stomach cancer
Radical gastrectomy Irradiation Chemo
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What is the #1 autoimmune disorder in the US
Celiac disease
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What triggers celiac disease
Ingestion of gluten containing grains
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What kind of immune repsonse is is celiac disease
T cell mediated There is an increased level of Ab
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What are the symptoms/signs of celiac disease
Diarrhea Pruritic rash Itching/burning Abdominal pan ``` Bloating Irritability/depression Stomach upset Joint pain Muscle cramps Skin rash Mouth sores Dental/bone disorders Tingling of legs/feet ```
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How do you diagnose celiac disease
case Hx IgA- antitTG test Biopsy Flattened brow
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What is lactose intolerance
You dont have lactase enzyme to break down lactose, so it gets fermented by gut bacteria and causes gas, and abdominal pain
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How is lactose intolerance managed
Limit dairy product intake Use a substitute nutrient source to maintain energy and protein intake Use lactose products Eat yogurt with live and active cultures
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What are the 2 related chronic inflammatory disorders
Chrohn’s | Ulcerative colitis
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Where is Crohn’s disease localized
Any part of GI tract except the rectum SKIP lesions
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Where does ulcerative colitis localize
Colon Continuous inflammation Rectum is involved
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Where is the pain in Crohn’s disease
Lower right abdomen
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Where is pain in ulcerative colitis
Lower left abdomen
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What is the morphology of Crohn’s disease
``` Colon wall is thickened Transmural inflammation Cobblestone mucosa Ulcers Fistula ```
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What is the morphology of ulcerative colitis
``` Colon wall is thinner Mucosal inflammation Pseudopolyps Crypt abscesses Ulcers ```
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What are the complications of Crohn’s disease
``` Strictures Fistulas Perianal disease Malabsorption Nutritional depletion ```
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What are the complications of ulcerative colitis
Severe stenosis Toxic megacolon Colorectal carcinoma
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Is bleeding common in Crohns
No
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Is bleeding common in ulcerative colitis
Yes
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What are the ocular findings with Crohns
Non-granulomatous uveitis | 1-10%
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What are the ocular findings in ulcerative colitis
Non-granulomatous uveitis | 1-5%
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How do you treat Crohns and ulcerative colitis
Anti-inflammatorys Immunosuppressive agents Steroids Surgery
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What is the prognosis for Crohns and ulcerative colitis
Chronic | Constant monitoring
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What is IBS
Recurrent abdominal pain or discomfort 3 days/month for the past 3 months with symptoms onset of more than 6 month.
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What is associated with IBS
Pain relief with defecation Change in bowel habits Change in stool form
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Who is most affected by IBS
Females
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What can trigger IBS
Stress
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What foods can trigger IBS
Processed food High fructose corn syrup Milk formulas in infants
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How do you treat IBS
Stress management Increase fiber Avoid fatty, gas producing foods, alcohol, and caffeine Antispasmotics Anticholinergics Serotonin antagonist
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Heterochromia
Wtf?? | 2 different colored eyes....
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What is diverticulitis
Acquired her nations of the colonic mucosa and submucosa through the muscularis propria Occurs most commonly in the sigmoid colon
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What is diverticulosis
Presence of diverticula in an individual who is asymptomatic
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What is diverticular disease
Reserve of diverticula associated with symptoms 20% of individuals with diverticula
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What are the symptoms of diverticulosis
Abdominal pain (LL quad) N/V Tenderness Fever
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How do you diagnose diverticulosis
``` Case Hx Barium enema CT scan Endoscopy Ultrasound ```
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What are the complications of diverticulosis
``` Diverticulitis Perforation with peritonitis Abscess Hemorrhage Bowel obstruction Fistulas ```
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What is appendicitis
Inflammation of the appendix
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What are the symptoms of appendicitis
Periumbilical pain (dull and steady) Low grade fever Nausea Anorexia
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What does sudden pain relief in appenditcitis indicate
Rupture of appendix | But they can have rebound pain or tenderness
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What is the #1 cancer of GIT
Colorectal adenocarcinoma
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What are the risk factors for colorectal cancer
``` Age Family Hx of cancer Crohn’s disease or ulcerative colitis Familial adenomatous polyposis Diet ```
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What can help protect you from colorectal cancer
Vitamin A, C, E
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What is the presentation of colorectal cancer
Symptoms come later Bleeding** ``` Change in bowel habits Diarrhea Constipation Sense of urgency Sense of incomplete emptying PAIN is later ```
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How do you treat colorectal cancer
Surgical removal | Radio/chemotherapy
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What is the prognosis for colorectal cancer Stage 1
5 year survival rate of 90-100%
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What is the prognosis for stage 4 colorectal cancer
Metastatic | Poor prognosis
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Prevention is key!!
We are what we eat Eat a fresh healthy diet Avoid irritants
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For stage 3 colorectal cancer how do you treat it
Do radiation to reduce the size Then surgery
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How do you treat stage 4 colorectal cancer
Surgery | Then radiation therapy