Block 3 Drugs List Flashcards by Gursh Hayer

Dopaminergics

Pharmacology of basal ganglia disorders

Generic Drug Name(s):
levodopa (L-dopa)

Principal MoA:
Dopamine precursor

Generic Drug Name(s):
pramipexole
ropinirole
rotigotine

Principal MoA:
Dopamine receptor agonist (synthetic)

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Dopa-decarboxylase inhibitor

Pharmacology of basal ganglia disorders

Generic Drug Name(s):
carbidopa
benserazide

Principal MoA:
Stops breakdown of Levadopa in the periphery by inhibiting dopa-decarboxylase

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COMT (catechol-O-methyl transferase) Inhibitor

Pharmacology of basal ganglia disorders

Generic Drug Name(s):
entacapone
tolcapone

Principal MoA:
Stops breakdown of DA in CNS by inhibition of COMT

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MAOB (monoamine oxidase, B form) Inhibitor

Pharmacology of basal ganglia disorders

Generic Drug Name(s):
rasagiline
selegiline

Principal MoA:
Stops breakdown of DA in CNS by inhibition of MAOIB

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Anticholinergics

Pharmacology of basal ganglia disorders

Generic Drug Name(s):
orphenadrine
procyclidine
trihexphenidyl

Principal MoA:
Muscarinic cholinergic receptor antagonist

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Anti-Parkinsonism

Pharmacology of basal ganglia disorders

Generic Drug Name(s):
Amantadine

Principal MoA:
Antiviral. Glutamate (NMDA) receptor antagonist, dopamine agonist

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Antipsychotics

Pharmacology of basal ganglia disorders

Generic Drug Name(s):
Separate Cards

Principal MoA:
Dopamine receptor antagonists

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Dopamine-depleting drugs

Pharmacology of basal ganglia disorders

Generic Drug Name(s):
tetrabenazine

Principal MoA:
Blocks VMAT, preventing uptake of DA into vesicles

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Weak analgesic/ antipyretic

Analgesic drugs

Generic Drug Name(s):
paracetamol

Principal MoA:
Non-selective COX inhibitor (CNS)

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Non-steroidal anti-inflammatory drugs (NSAIDs)

Analgesic drugs

Generic Drug Name(s):
aspirin
ibuprofen
diclofenac
naproxen

Principal MoA:
Non-selective COX inhibitor

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COX2-selective NSAIDs

Analgesic drugs

Generic Drug Name(s):
celecoxib
etoricoxib

Principal MoA:
Selective COX-2 inhibitor

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Weak opioid analgesics

Analgesic drugs

Generic Drug Name(s):
codeine
dihydrocodeine

Principal MoA:
Opioid receptor agonist

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Strong opioid analgesics

Analgesic drugs

Generic Drug Name(s):
morphine
diamorphine

Principal MoA:
Opioid receptor agonist

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Partial/mixed agonist-antagonist opioid analgesics

Analgesic drugs

Generic Drug Name(s):
buprenorphine

Principal MoA:
Opioid receptor agonist (μ)/antagonist (κ)

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Opioid receptor antagonists

Analgesic drugs

Generic Drug Name(s): naloxone
naltrexone

Principal MoA:
Opioid receptor antagonist

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Synthetic opioid

Analgesic drugs

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Generic Drug Name(s):
tramadol

Principal MoA:
Opioid receptor agonist and serotonin/noradrenaline reuptake inhibitor

Drugs used in management of opioid addiction

Analgesic drugs

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Generic Drug Name(s):
methadone

Principal MoA:
Opioid receptor agonist

Generic Drug Name(s):
buprenorphine

Principal MoA:
Opioid receptor agonist (μ)/antagonist (κ)

Drugs used to treat neuropathic pain

Analgesic drugs

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Generic Drug Name(s):
gabapentin (AED)

Principal MoA:
Inhibits VDCC, Increases GABA transmission

Generic Drug Name(s):
pregabalin (AED)

Principal MoA:
Inhibits VDCC

Generic Drug Name(s):
carbamazepine (AED)

Principal MoA:
Sodium channel blocker

Tricyclic Antidepressants (TCAs)

Pharmacology of Depression

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Generic Drug Name(s): 
amitriptyline
nortriptyline
imipramine
clomipramine

Principal MoA:
SRI, NRI, H1 antagonist, M1 antagonist, Adrenergic antagonist

Selective serotonin reuptake inhibitors (SSRIs)

Pharmacology of Depression

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Generic Drug Name(s):
sertraline
citalopram

Principal MoA:
Inhibits serotonin (5HT) reuptake pump

Monoamine (A) oxidase inhibitors (MAOIs)

Pharmacology of Depression

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Generic Drug Name(s):
moclobemide

Principal MoA:
Stops breakdown of monoamines in CNS. Reversible inhibitor of monoamine oxidase A (RIMA)

Atypical Antidepressants

Pharmacology of Depression

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Generic Drug Name(s):
reboxetine

Principal MoA:
NRI

Generic Drug Name(s):
bupropion

Principal MoA:
NDRI

Generic Drug Name(s):
agomelatine

Principal MoA:
melatonin agonist

Generic Drug Name(s):
venlafaxine

Principal MoA:
SNRI

Generic Drug Name(s):
mirtazapine

Principal MoA:
α2-Adrenergic antagonist

Anxiolytic (adjunct)

Pharmacology of Depression

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Generic Drug Name(s):
buspirone (anxiolytic)

Principal MoA:
5HT1a partial agonist

1st Generation Antipsychotics

Antipsychotics

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Generic Drug Name(s):
chlorpromazine
haloperidol

Principal MoA:
Selective dopamine (D2) receptor antagonist

2nd Generation Antipsychotics | Antipsychotics

Generic Drug Name(s): amisulpride Principal MoA: Serotonin (5HT7) and dopamine (D2) antagonist Generic Drug Name(s): risperidone clozapine Principal MoA: Serotonin (5HT2A) and dopamine (D2) antagonist

3rd Generation Antipsychotics | Antipsychotics

Generic Drug Name(s): aripiprazole Principal MoA: Partial agonist at 5HT and DA receptors

Anxiolytic (adjunct in depression) | Anxiolytics and related drugs

Generic Drug Name(s): buspirone (anxiolytic) Principal MoA: 5HT1a partial agonist

Muscle relaxants/sedatives/anxiolytic-hypnotic | Anxiolytics and related drugs

Generic Drug Name(s): zolpidem (‘Z-drug’) ``` Principal MoA: GABA PAM (mechanistically identical to BDZ) ``` Generic Drug Name(s): temazepam (BDZ) Principal MoA: GABA PAM Generic Drug Name(s): dexmedetomidine Principal MoA: α2-adrenergic receptor agonist Generic Drug Name(s): alfentanil fentanil (or ‘-yl’) remifentanil Principal MoA: Opioid receptor agonist (short-acting)

Symptom reduction (autonomic) | Anxiolytics and related drugs

Generic Drug Name(s): propranolol Principal MoA: β-blocker

Anti-epilepsy drugs (AEDs) | Drugs used for epilepsy

Generic Drug Name(s): sodium valproate lamotrigine carbemazepine Principal MoA: Sodium channel blocker Generic Drug Name(s): Calcium channel blocker (T-type)

Benzodiazepines (BDZ) | Drugs used for epilepsy

Generic Drug Name(s): midazolam lorazepam diazepam ``` Principal MoA: GABA PAM (γ-subunit) ```

BDZ Antagonist | Drugs used for epilepsy

Generic Drug Name(s): flumazenil Principal MoA: Competitive antagonist at BDZ site

Barbiturates (Barb) | Drugs used for epilepsy

Generic Drug Name(s): phenobarbitone pentobarbitone primidone ``` Principal MoA: GABA PAM (β -subunit) ```

Adjuncts | Drugs used for epilepsy

Generic Drug Name(s): vigabatrin Principal MoA: Inhibits GABA breakdown by GABA transaminase Generic Drug Name(s): tiagabin Principal MoA: GABA reuptake inhibitor Generic Drug Name(s): levetiracetam Principal MoA: Unclear MoA

Anticholinesterases | Drugs used for dementia

Generic Drug Name(s): donepezil galantamine rivastigmine Principal MoA: Inhibitor of acetylcholinesterase (reversible)

Glutamate (NMDA) receptor antagonists | Drugs used for dementia

Generic Drug Name(s): memantine Principal MoA: VD blocker of NMDA receptors (NMDA NAM)

Antimicrobial drugs | Drugs used for CNS Infection

Generic Drug Name(s): Ceftriaxone (see antibiotics, Block 4) Principal MoA: Inhibits synthesis of cell walls in bacteria Generic Drug Name(s): amoxicillin (see antibiotics, Block 4) Principal MoA: Induces cell lysis by blocking last stages of cell wall synthesis

Corticosteroid (see also Block 2) | Drugs used for CNS Infection

Generic Drug Name(s): dexamethasone Principal MoA: Glucocorticoid receptor agonist

Block 3 Drugs List Flashcards

(38 cards)