Blood And Hematopoiesis Flashcards Preview

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Flashcards in Blood And Hematopoiesis Deck (16):
1

Plasma

-with anticoagulants
- liquid portion consisting of water and a variety of proteins and organic compounds

2

Serum

- liquid portion remaining after blood has been allowed to clot
- without anti-coagulants

3

Erythrocytes

- most numerous cell type (120 day lifespan)
- Biconcave disc
- no nuclei or organelles
- filled with hemoglobin
- flexible membrane cytoskeleton permits movement through small capillaries

4

RBC membrane proteins

- peripheral proteins form a network for structure and support to the membrane
- integration proteins anchor the network to the membrane

5

Leukocytes (granular)

- neutrophils, eosinophils, basophils
- PMNs
-myeloid lineage

6

Leukocytes (agranular)

- no granules
- round nuclei
- myeloid lineage (monocytes that differentiate into macrophages in connective tissue)
- Lymphoid lineage
( T and B type lymphocytes), B turns to plasma cells

7

Neutrophils

- Primary - lysosomes containing elastase and myeloperoxidase
-Secondary - variety of digestive enzymes
- Nucleus- segmented into 3-5 lobes
-LS is a few hours to a few days
-phagocytic
- pale stain

8

Eosinophils

- primary- similar to neutrophils
- secondary- variety of digestive enzymes
- bilobed nucleus
- LS is a few hours to few days
- mediate allergic reactions and protect against parasitic infections
- pink stain

9

Basophils

-few primary granules
- secondary - histamine, heparin
- nucleus is bilobed
- mediates allergic reaction
- dark blue stain

10

Lymphocytes

-agranular
- small round cells with thin rim of pale cytoplasm
- T and B are indistinguishable by LM
- T and B have cell surface proteins that are specific for their functions in the immune system
- T cells - cell mediated immunity
-B cells - humoral immunity, turn to plasma cells
-LS a few days to few years

11

Monocytes

- agranular
- kidney shaped or oval nucleus
- precursor of macrophages and osteoclasts
- phagocytic
-antigen presentation
- bone remodeling
- LS is a few hours in circulation and differentiate in CT or bone

12

Platelets

- cytoplasmic fragments of megakaryocytes
- blood clotting

13

Parenchyma

- developing blood cells in cords or islands and sinusoidal capillaries that are entry site for blood cells into circulation

14

Red bone marrow

- site of hematopoiesis

15

Yellow bone marrow

- hematopoietic marrow replaced by fat

16

Stroma

- reticular CT supporting the blood cells