Blood Bank Chapter 6 ABO Blood Group System Flashcards Preview

Med Lab Tech Fall 2016 > Blood Bank Chapter 6 ABO Blood Group System > Flashcards

Flashcards in Blood Bank Chapter 6 ABO Blood Group System Deck (16):
1

ABO antibodies are what type of immunoglobulin?

IgM (can be a little IgG)

2

ABO genes are on this chromosome

Chromosome 9

3

A newborn has this number of antigen sites compared to an adult

25-50% of sites on an adults RBC

4

ABH antigen formation results from

The interaction of genes at 3 seperate loci (ABO, Hh, and Se)

5

H antigen-precursor for A and B forms what?

type 2 chain - beta1-4 linkage- galactose is attached to N-acetylglucosamine

6

What is H gene and its functions?

An enzyme, fucosyltransferase- adds fucose to terminal galactose of type 2 chain.

7

Terminal Sugar

immunodominant sugar-sugar that determines specificity

8

Which ABO group has the highest amount of H?

Group O

9

Which ABO group has the least amount of H?

A_1B

10

A gene-produces?

N-acetylgalactosaminyltransferase

11

What does B gene produce?

D- galactosyltransferase-

12

Which ABO blood group is more efficient? A or B?

Group B is more efficient. ( a sites- 600,000 b sites 720,000 )

13

Sese is a secreter? (T/F)

Sese is a secretor, (80% of US are secretors)

14

Dolichos biflorus agglutinates what cells?

A1 or A1B

15

Group I ABO discrepancy

unexpected reactions in the reverse due to weak reacting or missing antibodies

reasons include newborns, elderly, CLL, lymphoma...

16

Group II ABO discrepancy

unexpected reaction in forward type due to weakly reacting or missing antigens

seen in leukemia, hodgkins, aquired B, and chimerism