Blood cell tutorial Flashcards
(20 cards)
Where do granulocytes do most of their work? i.e. tissues or bloodstream
Tissues
How many days does it take for division and maturation of eosinophils/basophils/neutrophils?
6-8 days
Which type of cell is able to stick to the blood vessel wall (marginate) ?
Neutrophils
How long do neutrophils spend in the blood stream?
Neutrophils are short lived, they spend 6-10 hours in the blood stream, before spending a few days in the tissue and dying
Which of the following can cause eosinophila? :
- malaria
- asthma
- sepsis
- severe eczema
- helminthic infection
- asthma
- severe eczema
- helminthic infection
Which of the following can cause neutrophilia? :
- neoplasia (e.g. carcinoma)
- inflammation
- bacterial infection (especially pyogenic bacteria)
- acute haemorrhage
- tissue necrosis
All of them
Where would you find basophils?
Do not usually circulate in blood, would find them in connective tissues
When might you see basophils?
- asthma
- polycythaemia rubra vera
- chronic myleoid leukaemia
What could cause an increase in the number of eosinophils?
- allergic reactions to drugs
- severe skin conditions (e.g. atopic dermatitis)
- Asthma, atopy
- Parasitic infections
- Hodgkins lymphoma, T cel lymphomas
- PULMONARY SYNDROMES (e.g. eosinophilic pneumonia, Churg Strauss)
The nucleus of this cell is often obscured by blue/black granules
Basophil
What do basophil granules contain?
- heparin
- histamine
What type of receptor would you find on the surface of basophils?
-IgE receptors (these allow specific antibody/antigen interactions to cause degranulation - type 1 hypersensitivity)
Which of the following would cause increased levels of mast cells? :
- systemic mastocytosis
- immune complex disease
- a recent anaphylactic reaction
- severe sepsis
Answer:
- systemic mastocytosis
- recent anaphylactic reaction
What can be measured to look for mast cell degranulation/excessive mast cell numbers
(mast cell) tryptase !!
Malignant proliferation of mast cells causes what?
Systemic mastocytosis
Monocytosis can be seen in which of the following:
- connective tissue disease
- malignancy
- chronic bacterial infection
- smokers
Answer:
- connective tissue diseases (e.g. SLE, rheumatoid arthritis)
- malignancy (e.g. chromic myelomonocytic leukaemia)
- chronic bacterial infections
Wouldn’t see monocytosis in smokers although you could see a mild neutrophilia
How long do monocytes circulate for?
Circulate for 1-2 days before entering the tissues
-under the influence of local factors, differentiate into tissue macrophages
When might you see a lymphocytosis?
Lymphocytosis is caused by response to infection or underlying malignant process, and can be seen after removal of the spleen (hyposplenism)
What do IgM specific antibodies confirm?
IgM specific antibodies confirm recent infection
What do IgG specific antibodies indicate?
Past infection
