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clin med IV > Blood cells general info > Flashcards

Blood cells general info Flashcards

(57 cards)

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1
Q

components of whole blood

A
  • erythrocytes
  • leukocytes
  • thrombocytes
  • plasma cells
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2
Q

pancytopenia

A
  • decreased all lines of cells

- RBC, WBC, platelets

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3
Q

anemia

A
  • decreased RBC and RBC parameters
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4
Q

polycythemia

A
  • increased RBC
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5
Q

thrombocytopenia

A
  • decreased platelets
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6
Q

thrombocytosis

A
  • increased platelets
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7
Q

leukocytosis

A
  • increased WBC
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8
Q

leukopenia

A
  • decreased WBC
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9
Q

neutropenia

A
  • decreased neutrophils

- ANC < 1000

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10
Q

leukemoid reaction

A
  • benign and temporary leukocytosis
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11
Q

hematopoiesis

A
  • production of blood cells
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12
Q

erythropoiesis

A
  • prod of RBCs
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13
Q

thrombopoiesis

A
  • prod of platelets
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14
Q

leukopoiesis

A
  • prod of WBCs
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15
Q

lymphopoiesis

A
  • prod of lymphocytes
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16
Q

medularry myeloid hematopoiesis

A
  • prod of myeloid blood cells in bone marrow

- post natal occurs in vertebra, sternum, rib, femur, tibia

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17
Q

extramedullary myeloid hematopoiesis

A
  • prod of blood cells outside of bone marrow

- liver or spleen

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18
Q

bands

A
  • immature neutrophils
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19
Q

blast cells

A
  • immature cells
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20
Q

poikilocytosis

A
  • change in shape
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21
Q

what are the most abundant blood cells in body

A
  • RBCs
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22
Q

what is the purpose of RBCs

A
  • gas transport/ oxygen transport
  • deliver oxygen
  • eliminate CO2
  • biconcave shape allows flexibility/ deformability
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23
Q

life span of RBCs

24
Q

what is the role of haptoglobin

Study These Flashcards
A
  • maintains iron stores
25
what is the role of hemopexin
- scavenge RBC contents
26
what stimulates new RBC production
- EPO | - hypoxia inducible factor (HIF)
27
what is hemoglobin made up of
- 2 alpha globins - 2 beta globins - bound to heme group which contains iron
28
what raw materials are required for RBC production
- b12 - folate - B6 - iron - copper - amino acids, proteins
29
what is EPO
- stimulates erythropoiesis - produced by kidneys - small amounts produced by liver
30
when does erythropoiesis occur
- decreased RBCs - decreased hemoglobin synthesis - decreased BF - hemorrhage - increased O2 consumption by tissues
31
RBC senescence and break down
- as RBCs age they become less flexible, more fragile - phagocytized by macrophages in liver, spleen, bone marrow - normally loss= production
32
what do RBCs get broken down into
- heme group - protein group - heme gets broken down into iron and bilirubin - iron gets recycled, bilirubin gets degraded
33
what are the hgb parameters for anemia
- hgb < 13 in men | - hgb < 12 in women
34
what is mild anemia
- hgb 10
35
what is mod anemia
- hgb 8-9.9
36
what is severe anemia
- hgb 6.5 - 7.9
37
what is life threatening anemia
- < 6.5
38
microcytic anemia
- MCV < 80
39
normocytic anemia
- MCV 80-100
40
macrocytic anemia
- MCV > 100
41
what is the MCV
- average size of RBCs
42
what is the MCH
- average weight of hgb in RBCs
43
what is the MCHC
- average concentration of hgb in RBCs
44
what is the RDW
- red blood cell distribution width - tells you variation in size of RBCs - high- a lot of difference sized cells - low- a lot of same sized cells
45
what are reticulocytes
- immature RBCs
46
why are reticulocyte counts important
- if increased it means bone marrow is working | - as anemia worsens, RBCs leave marrow sooner
47
what do low reticulocyte counts mean in anemia
- marrow infiltration: leukemia, lymphoma, malignancy - marrow failure: pure red cell aplasia, MDS, fibrosis - def in raw materials: B12, Fe, folate
48
what is hct
- Hgb X 3 | - expressed as %
49
what is hgb electrophoresis
- tests contents of RBCs against bands for various hgb types | - often used in thalassemias
50
cells that are derived from lymphoid progenitor cells
- B cells - T cells - NK cells
51
what cells are derived from myeloid progenitor cells
- RBCs - platelets - WBCs: monocytes, neutrophils, eospinophils, basophils
52
what blood cells have nuclei
- WBCs | - RBCs and platelets DO NOT
53
what is the role of eospinophils
- parasites | - allergies
54
what is the role of basophils
- mast cell production
55
what is the role of neutrophils
- bacterial infection | - bands= immature neutrophils
56
what is the role of B and T cells
- viral infections
57
what cells are phagocytes
- monocytes | - neutrophils

clin med IV (23 decks)

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