Blood Clotting

Question 1

Platelets or thrombocytes are cell fragments arising from large precursor cells called

Answer 1

Megakaryocyte

Question 2

———-: cessation of bleeding from a cut or severed vessel.
• ———: occurs when the endothelium lining blood vessels is damaged or removed.

Answer 2

Hemostasis: cessation of bleeding from a cut or severed vessel.
• Thrombosis: occurs when the endothelium lining blood vessels is damaged or removed.

Question 3

—- thrombus: composed of platelets and fibrin but relatively poor in erythrocytes.

Answer 3

White

Question 4

Which thrombus Formation occur at sites of an injury or abnormal vessel wall particularly at arteries where blood flow rapidly

Answer 4

White

Question 5

——- thrombus: consists of red cells and fibrin. Formed in vivo in areas of retarded blood flow or
stasis e.g vein.

Answer 5

Red thrombus: consists of red cells and fibrin. Formed in vivo in areas of retarded blood flow or
stasis e.g vein.

Question 6

Intrinsic
and extrinsic pathway leads to activation of factor —-
Both pathways
Initiates t h e fibrin clot in response to tissue injury.
It also involves a ——
charged surface.
The common pathway that
converge the intrinsic and
extrinsic pathways involve the
activation of prothrombin to —— and the thrombin-
catalyzed cleavage of ——- to —— clot.

Answer 6

Intrinsic
and extrinsic pathway leads to activation of factor X
Both pathways
Initiates t h e fibrin clot in response to tissue injury.
It also involves a negatively
charged surface.
The common pathway that
converge the intrinsic and
extrinsic pathways involve the
activation of prothrombin to thrombin and the thrombin-
catalyzed cleavage of fibrinogen to fibrin clot.

Question 7

Proteins of clotting pathways

Answer 7

Proteins of clotting pathways
• Zymogens of serine-dependent proteases • Co-factors
• Fibrinogen
• Transglutaminase-stabilizes fibrin clot • Regulatory proteins

Question 8

Factors—-, —-, —-, and — are Gla-containing zymogens.] (Gla = y-carboxyglutamate.)

Answer 8

2, 7,9,10

Question 9

List the zymogens of serine proteases

Answer 9

Clotting factors 12,11,9,7,10,2

Question 10

List the Cofactors

Answer 10

Factors 8, 5,3

Question 11

Which clotting is a Thiol-dependenttransglutaminase

Answer 11

Factor 13

Question 12

List 3 regulatory proteins

Answer 12

Protein C
Protein S
Thrombomodulin