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Biochemistry Theory Semester 1 > Blood Clotting > Flashcards

Blood Clotting Flashcards

(63 cards)

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1
Q

Front

A

Back

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2
Q

Which pathway is overactivated in Factor V Leiden mutation as shown in the diagram?
[Insert diagram showing protein C resistance]

A

A. Protein C–S pathway
B. Extrinsic pathway
C. Plasminogen activation pathway
D. Platelet activation pathway
Correct Answer: A

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3
Q

In this diagram, which step is blocked by warfarin?
[Insert vitamin K recycling and gamma-carboxylation pathway]

A

A. Fibrin polymerization
B. Activation of thrombin
C. Epoxide reductase inhibition
D. Plasmin activation
Correct Answer: C

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4
Q

Which mutation site leads to protein C resistance?
[Insert diagram showing Factor V mutation]

A

A. Factor IXa binding site
B. Factor Va cleavage site
C. Prothrombin binding site
D. Calcium binding site
Correct Answer: B

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5
Q

Which enzyme in the diagram regulates fibrinolysis by inhibiting plasmin?
[Insert diagram with α2-antiplasmin labeled]

A

A. Heparin
B. Streptokinase
C. α2-antiplasmin
D. Urokinase
Correct Answer: C

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6
Q

What process is inhibited by TAFI in the diagram?
[Insert diagram of clot stabilization showing TAFI action]

A

A. Clot formation
B. Plasmin formation
C. Fibrin cross-linking
D. Fibrinolysis
Correct Answer: D

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7
Q

What is the mechanism of action of Factor XIIIa?

A

A. Degrades fibrin
B. Cross-links fibrin
C. Inhibits thrombin
D. Activates plasminogen
Correct Answer: B

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8
Q

Which protein is mutated in Haemophilia B?

A

A. Factor VII
B. Factor IX
C. Factor X
D. Factor VIII
Correct Answer: B

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9
Q

What is the role of TAFI (Thrombin Activatable Fibrinolysis Inhibitor)?

A

A. Inhibits clotting
B. Inhibits thrombin
C. Inhibits fibrinolysis
D. Enhances protein C
Correct Answer: C

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10
Q

Which factor is NOT dependent on vitamin K for synthesis?

A

A. Factor II
B. Factor VII
C. Factor IX
D. Factor VIII
Correct Answer: D

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11
Q

What is the effect of thrombomodulin binding to thrombin?

A

A. Enhances thrombin’s clotting activity
B. Inhibits thrombin’s activity
C. Switches thrombin to an anticoagulant role
D. Activates fibrin polymerization
Correct Answer: C

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12
Q

Factor VIII is stabilized in circulation by von Willebrand factor.

A

True

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13
Q

Warfarin acts as a direct thrombin inhibitor.

A

False

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14
Q

TAFI activation reduces fibrinolysis.

A

True

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15
Q

Protein C deficiency can result in hypercoagulability.

A

True

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16
Q

Factor V Leiden is more susceptible to degradation by Protein C.

A

False

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17
Q

Urokinase is a naturally occurring fibrinolytic agent.

A

True

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18
Q

Thrombomodulin is a cofactor for plasminogen activation.

A

False

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19
Q

Factor XIII deficiency leads to delayed bleeding despite normal clot formation.

A

True

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20
Q

Heparin is a vitamin K antagonist.

A

False

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21
Q

α2-antiplasmin deficiency results in increased clot stability.

A

False

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22
Q

Front

A

Back

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23
Q

Which labeled inhibitor in the diagram enhances the activity of Antithrombin III?
[Insert clotting inhibition pathway with heparin labeled]

A

A. Protein C
B. Thrombomodulin
C. Heparin
D. Plasmin
Correct Answer: C

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24
Q

Which pathway is initiated by tissue factor as shown in the diagram?
[Insert labeled clotting cascade with tissue factor]

A

A. Intrinsic pathway
B. Extrinsic pathway
C. Common pathway
D. Fibrinolytic pathway
Correct Answer: B

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25
In the diagram, which factor acts as a cofactor for the activation of Factor X? [Insert clotting cascade with VIIIa and IXa]
A. Factor V B. Factor VIIa C. Factor VIIIa D. Factor XIIIa Correct Answer: C
26
Which labeled agent converts plasminogen to plasmin in the diagram? [Insert diagram of fibrinolysis process]
A. Warfarin B. TPA C. Factor XIII D. Protein C Correct Answer: B
27
What outcome is shown resulting from fibrin cross-linking by Factor XIIIa? [Insert image showing stable fibrin mesh]
A. Clot degradation B. Platelet activation C. Clot stabilization D. Inhibition of thrombin Correct Answer: C
28
What is the primary action of warfarin in clotting regulation?
A. Inhibits plasminogen B. Inhibits vitamin K recycling C. Activates thrombin D. Enhances fibrin formation Correct Answer: B
29
Which protein complex inactivates Factors Va and VIIIa?
A. Plasmin–plasminogen complex B. Heparin–ATIII complex C. Protein C–Protein S complex D. TPA–plasmin complex Correct Answer: C
30
Which clotting factor is activated by both intrinsic and extrinsic pathways?
A. Factor VII B. Factor X C. Factor V D. Factor XIII Correct Answer: B
31
What does plasmin specifically degrade?
A. Fibrin B. Thrombin C. Prothrombin D. Vitamin K Correct Answer: A
32
Which drug activates plasminogen to break down clots?
A. Warfarin B. Streptokinase C. Heparin D. Aspirin Correct Answer: B
33
Factor X is part of both intrinsic and extrinsic pathways.
True
34
Antithrombin III promotes fibrin formation.
False
35
Protein C requires thrombin for its activation.
True
36
Fibrinolysis is activated before clot formation is complete.
False
37
TPA is a natural fibrinolytic agent.
True
38
Warfarin inhibits thrombin directly.
False
39
Heparin enhances the activity of Antithrombin III.
True
40
Factor V is a vitamin K–dependent factor.
True
41
Protein C acts independently without Protein S.
False
42
Streptokinase dissolves clots by activating plasminogen.
True
43
Front
Back
44
Which structure in the diagram represents the site of fibrin formation? [Insert diagram of clotting cascade with thrombin and fibrin pathways]
A. Prothrombin B. Thrombin C. Fibrinogen D. Fibrin Correct Answer: D
45
What enzyme is labeled that cross-links fibrin to stabilize the clot? [Insert diagram with Factor XIIIa and fibrin strands]
A. Factor XII B. Factor XIIIa C. Thrombin D. Plasmin Correct Answer: B
46
Which factor is shown initiating the extrinsic pathway in the diagram? [Insert clotting cascade with tissue factor labeled]
A. Factor IX B. Factor VIII C. Tissue Factor (III) D. Factor X Correct Answer: C
47
What step is represented by the arrow from fibrinogen to fibrin? [Insert coagulation cascade diagram]
A. Activation by calcium B. Cleavage by thrombin C. Binding by vitamin K D. Cross-linking by TPA Correct Answer: B
48
What is being inhibited in the diagram by heparin binding to ATIII? [Insert pathway showing thrombin inhibition]
A. Fibrin B. Thrombin C. Plasmin D. Factor XIIIa Correct Answer: B
49
What is the inactive precursor of thrombin?
A. Fibrin B. Factor VII C. Prothrombin D. Plasminogen Correct Answer: C
50
Which vitamin is essential for the synthesis of clotting factors?
A. Vitamin C B. Vitamin D C. Vitamin B12 D. Vitamin K Correct Answer: D
51
Which factor initiates the intrinsic pathway?
A. Factor XII B. Factor X C. Factor VII D. Factor V Correct Answer: A
52
Which of these is a fibrinolytic agent?
A. Aspirin B. Heparin C. Streptokinase D. Warfarin Correct Answer: C
53
Which clotting factor is deficient in Haemophilia A?
A. Factor VIII B. Factor IX C. Factor X D. Factor VII Correct Answer: A
54
Thrombin converts fibrinogen to fibrin.
True
55
Vitamin K is required for the activation of plasmin.
False
56
Fibrin stabilizes blood clots.
True
57
Aspirin is a clotting factor.
False
58
TPA helps dissolve blood clots.
True
59
Factor XIII is involved in cross-linking fibrin.
True
60
Plasmin degrades fibrin clots.
True
61
Calcium ions are not involved in blood clotting.
False
62
Warfarin acts by inhibiting vitamin K recycling.
True
63
Prothrombin is the same as plasminogen.
False

Biochemistry Theory Semester 1 (12 decks)

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