Blood Coagulation Flashcards
(22 cards)
Binds to thrombin and converts from a procoagulant to an anticoagulant by activating protein C
Thrombomodulin
Triad of Thrombotic Thrombocytopenic purpura
- Microangiopathic hemolytic anemia
- thrombocytopenia
- neurological disorders
Idiopathic Thrombocytopenic purpura is what type of hypersensitivity disorder?
Type II - due to virus, there is alteration in antigen of platelet which is attacked by AB
An increase in circulating platelet
Thrombocytosis
Iron deficiency anemia with chronic blood loss will result in..
Secondary Thrombocytosis
A disease where there is a decrease in vWF receptor?
Bernard-Soulier Disease
A disorder of platelet-platelet interaction because of a decrease in surface glycoproteins IIb and IIa
Glanzmann’s Thrombasthenia
G = glycoprotein
Normal platelet count
150k-400k/mm^3
What pathway is triggered by damage to endothelial lining of blood vessel?
Intrinsic Pathway
What pathway is triggered by the release of tissue thromboplastin (Factor III)?
Extrinsic Pathway
What test is abnormal in Classic Hemophilia?
aPTT is abnormal
Factor found both in extrinsic and intrinsic pathway?
Factor X (Stuart Factor)
Factors synthesized in the Liver?
Factor I, II, V, VI
Which factor is/are increased at birth?
Factor VIII (vWF factor)
Which factor is/are acute phase reactants?
Factor I (fibrinogen) and Factor VIII: Ag (vWF factor)
Assess Factor XIII (Fibrin stabilizing factor)
5M Urea clot dissolution time
Monitor extrinsic pathway and anticoagulant therapy with coumadin?
Prothrombin Time
Measures level of plasminogen activator?
Clot Lysis Test
Inhibit Vitamin K utilization by Liver cells?
Coumarin
Binds to Anti-thrombin III to increase anticoagulant effect?
Heparin
Monitors intrinsic pathway and heparin therapy?
aPTT
Release of tissue thromboplastin (factor III) into blood stream
Disseminated intravascular coagulopathy (DIC)
