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Pharma > Blood II > Flashcards

Blood II Flashcards

0
Q

Exerts as anticoagulant by activating protein C ( clotting response attenuation)

A

Thrombin

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1
Q

Most common defect in natural anticoagulant system

A

Factor 5 leiden mutation

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2
Q

Protein C and S attenuate clotting by protein lysis of

A

5 and 8

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3
Q

Give 2 natural activators of fibrinolytic systrm

A

Tpa
Urokinase
Streptokinase

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4
Q

Inhibitor fibrinolysis

A

Aminocaproic acid

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5
Q

Synthetic inhibitor of fibrinolysis

A

Aminocaproic

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6
Q

Eaca contraindicated in patients with?

A

Genitiurinary bleeding (potential for excessive clotting)

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7
Q

Inhibits fibrinolysis by free plasmin; removed from the market in 2007 dt risks of kidney, heart problems and stroke

A

Aprotinin

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8
Q

Increases factor 8 activity of payients with MILD hrmophilia a or vwd

A

Desmopressin acet

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9
Q

Used to treat deficinecies or qualitative abnormalities of fibrinogen

A

Cryoprecipitate

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10
Q

Two forms of vitamin k?

A

Phytonadione

Menaquinone

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11
Q

Available clinically in oral and parenteral form for bleeding disorder (1972)

A

Vit k1

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12
Q 
Categorize based on target:
Dipyrimidazole
Abciximab
Aspirin
Clopidogrel
Tirofiban
A 
Phosphodiesterase
2b3a
Prostaglandin
Adp
2b3a
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13
Q

Inhibits txa2 by irreversible acetylation of the enzyme cycloox

A

Aspirin

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14
Q

Inhibits txa2 but no acrtylation

A

Ibuprofen

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15
Q

Irreversible blocking of adp receptor; first choice for aspirin intolerance

A

Adp blockers

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16
Q

Most serious effect of ticlopidine

A

Leukopenia

17
Q

Approved for stroke prevention w tia and in combo with aspirin

A

Ticlopidine

18
Q

Approved for non stemi in combo with aspirin

A

Clopidogrel

19
Q

Ae of clopidogrel

A

Neutropenia

20
Q

Approved for acute coronary sundromes and CI for stroke and TIA

A

Prasugrel

21
Q

Group of drugs for acute coronary syndrom and angioplasty

A

2b 3a

22
Q

Look alike of fibrinogen (carboxyl end) mediates binding of fibrinogen to receptor

A

Eptifibatide

23
Q

Smaller molecule than eptifibatide

A

Tirofiban

24
Q

Newer phosphodiesterase that promotes vasodilation and inhibition of platelet aggregation; for claudication

A

Cilostozol

25
Q

Has many uses other than inh of phosphodiesterase… Such as blood viscosity and rbcs

A

Pentoxifylline ( sounds like flexible)

26
Q

1st generatiob fibrinolytics

A

Strepkinase

Urokinase

27
Q

Fibrinolytic that Does not cross placental membrane that is produced by strep

A

Strptokinase

28
Q

Prototype thrombolytic agent

A

Strptokinase

29
Q

Restore patency to:
Central venous catheters?
Arteriovenous cannula

A

Uro

Steptokinase

30
Q

Plasminogen plus strep protein; acylated to protect active site

A

Anistreptilase

31
Q

Converts trapped plasminogen rather circulating to plasmin; recombinant dba texhnology produced

A

Alteplase

32
Q

Mutant form of tPa that has longer half life and more fibrin specific

A

Tenecteplase

33
Q

Group of drug with interaction with thrombin which has effect on f10

A

Indirect thrombin inhibitors

34
Q

Effect of long term heparin therapy

A 
Osteoporosis
Mineralocorticoid deficiency ( aldosterone)
35
Q

Treatment for heparin induced thromocytopenia

A

Administer direct thrombin inhibitor

36
Q

Why is u. Heparin not injected IM?

A

Hematoma forms

37
Q

Inhibit factor 10 but less effect on thrombin

A

Lmw heparin

38
Q

Lmw heparin levels not measured in px?

A

ROP
Renal
Obesity
Pregnancy

39
Q

Synthetic pentasaccharide molecule that do not cross react with HIT antibodies

A

Fondaparinux

40
Q

Reverse action of heparin

A

Protamine sulfate

Pharma (12 decks)

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