blood infections Flashcards
(26 cards)
blood infection disease
bacterial : sepsis&septic shock. rheumatic fever, anthrax, brucellosis,plague,leptospirosis,lyme disease, Q fever.
viral: Burkitt’s lymphoma, mononucleosis, CMV AIDS heaemorrhagic fever
fungi: candidiasis
sepsis and septic shock stage:
- infalmmation and release of cytokines
2. lymphangitis, inflamed lymph vessels
sepsis G- pathogen
E.coli/ Klebsiella/ Pseudomonas
endotoxin
sepsis G+ pathogen
S. aureus. S. pyogenes
potent exotoxins(superantigens). TSST(toxic shock syndrome toxin)
Enterococci(hosptial aquire)
puerperal sepsis pathogen
group A strep: streptococcus pyogenes(b-haemolytic)
puerperal sepsis known as
childbirth or childbed fever
puerperal sepsis infect ___
uterus
anthrax pathogen
bacillus anthracis:
- large aerobic G+ rods . endospore-forming
- affect cattle and sheep
- disease rare in human
three form of anthrax
- cutaneous anthrax—–cantact spore
- gastrointestinal anthrax—–rare. ingest spore
- inhalation( pulmonary anthrax)
anthrax pathogenicity
- exotoxin enzymes:a.Edema factor(EF) b.Lethal factor(LF)
2. PA (protective antigen) binds the toxin to target cells.
brucellosis pathogen
brucella spp
-G- coccobacilli
subacute bacterial endocarditis pathogen
most a-haemolytic streptococci
subacute bacterial endocarditis transmission
dental work
acute bacteral endocarditis pathogen
staphylococcus aureus
rheumatic fever pathogen
strep. pyogenes(Group A)
burkitt’s lymphoma pathogen
EBV(hhv 4)
most common childhood cancer in africa
burkitt’s lymphoma
EBV(hhv 4) cause
- mononucleosis(self-limiting)
2. burkitt’s lymphoma(fatal)
CMV pathogen
HHV 5
HHV5 remain in
monocytes, neutrophils and T cells
HHV4 remain in
B cells
CMV shed virus in
saliva, semen, breast milk
CMV microscope shape
owl’s eyes
CMV symptoms
- healty: asymptoms
- immunocompromised: life- threatenting
- AIDs- cmv retinitis
- pregnancy—-fatal ,abrostion
