Blood Laboratory Findings

Question 1

What is the characteristic pattern in the

rise and fall of SCr in PRERENAL AZOTEMIA?

Answer 1

Modest rises in SCr
that return to baseline
with improvement in hemodynamic
status.

Question 2

What is the pattern of the rise and fall of SCr in Contrast Nephropathy?

Answer 2

Contrast nephropathy leads to a
RISE in SCr within 24–48 h,
PEAK within 3–5 days, and
RESOLUTION within 5–7 days.

Question 3

Pattern of SCr in Atheroembolic disease

Answer 3

More subacute (vs. contrast nephropathy) rises in SCr, although severe AKI with rapid increases in SCr can occur in this setting.

Question 4

Pattern of SCr in epithelial cell toxins such as aminoglycoside
antibiotics and cisplatin

Answer 4

Rise in SCr is characteristically delayed for

3–5 days to 2 weeks after initial exposure

Question 5

What are other labs aside for SCr that you can order?

Answer 5

CBC- anemia, eosinophilia, thrombocytopenia
Peripheral blood smear- schistocytes 
LDH
Haptoglobin
Von willebrand factor cleaving protease (ADAMTS13)
E.coli
K- hyperkalemia
PO4- hyperphosphatemia
Ca- Hypocalcemia

*Marked hyperphosphatemia with accompanying hypocalcemia suggests rhabdomyolysis or the tumor lysis syndrome.

Anion gap

Question 6

Serum creatine kinase and uric acid levels are often ELEVATED in RHABDOMYOLYSIS, while TUMOR LYSIS SYNDROME shows NORMAL OF MARGINALLY ELEVATED creatine kinase and markedly elevated serum uric acid. T or F?

Answer 6

T.

Question 7

Possible causes of anion gap in AKI

Answer 7

The anion gap
may be increased with any cause of uremia due to RETENTION OF ANIONS
such as phosphate, hippurate, sulfate, and urate (PHSU).

Question 8

co-occurrence of an increased anion gap and an osmolal gap + oxalate crystalluria and oxalate
deposition in kidney tissues

Answer 8

Ethylene

glycol poisoning

Question 9

Low anion gap may provide a clue to
the diagnosis of _______ due to the presence of unmeasured
cationic proteins.

Answer 9

Multiple myeloma

Question 10

Laboratory blood tests helpful for the diagnosis of

glomerulonephritis and vasculitis include:

Answer 10

-DEPRESSED complement
levels and
-HIGH TITERS of antinuclear antibodies (ANAs), antineutrophil cytoplasmic antibodies (ANCAs), antiglomerular basement membrane (Anti-GBM) antibodies, and cryoglobulins