Blood Product Transfusion Complications Flashcards
(21 cards)
What causes non haemolytic febrile reaction
Antibodies react w/ white cell fragments in blood products + cytokines that leaked from blood cell during storage
How does non haemolytic febrile reaction present (2)
Fever
Chills
What products cause non haemolytic febrile reaction (2)
Red cell transfusion
Platelet transfusion
Management of non haemolytic febrile reaction (3)
Stop or slow transfusion
Paracetamol
Monitor
What causes a minor allergic reaction
Foreign plasma proteins
Symptoms of minor allergic reaction (2)
Pruritus
Urticaria
Treatment of minor allergic reaction (3)
Temporarily stop the transfusion
Antihistamine
Monitor
Cause of anaphylaxis
Patients w/ IgA deficiency who have high anti IgA antibodies
Symptoms of anaphylaxis (4)
Hypotension
Dyspnoea
Wheezing
Angioedema
Treatment of anaphylaxis (3)
Stop the transfusion
IM adrenaline
ABC support (oxygen, fluids)
Cause of acute haemolytic reaction
ABO incompatible blood e.g. secondary to human error
Symptoms of acute haemolytic reaction (3)
Fever
Abdo pain
Hypotension
Treatment of acute haemolytic reaction (3)
Stop transfusion
Confirm diagnosis - patient identity, direct Coombs test, cross match
Supportive care - fluids
TACO cause (2)
Excessive rate of transfusion
Pre existing HF
TACO symptoms (2)
Pulmonary oedema
Hypertension
TACO treatment (2)
Slow or stop transfusion
Consider IV loop diuretic
TRALI symptoms (4)
Hypoxia
Pulmonary infiltrates on CXR
Fever
Hypotension
TRALI treatment (2)
Stop transfusion
Supportive care
How long till symptoms acute haemolytic
Mins after transfusion begins
Complications of acute haemolytic (2)
DIC
Renal failure
When does TRALI happen
Within 6 hrs
