Blood products Flashcards
components of blood
saline adenine glucose mannitol citrate
volume
230-340mls
storage blood and shelf life
4 degrees for 35 days
components of FFP
clotting factors fibrinogen plasma proteins esp albumin electrolytes physiological anticoagulants protein c protein s, antithrombin,
inidcations for FFP
clinically significant bleeding but without major haemorrhage if abnormal coagulation tests eg PT ratio or APTT
can give prophylaxis with abnormal coag having invasive procedures
warfarin clotting factors
II, VII, IX and X
reversal of warfarin
PCC prothrombin complex concentrate beryplex
heparin reversal
protamine binds heparin replenishes factor Xa
cyroprecipitate
fibrogen VWF factor VIII XIII fibronectin
indications for cryoprecipitate
clinically significant bleeding and fibronogen below 1.5
what is massive transfusion
replenish whole blood volume in 24 hours or 10 units
categories of transfusion complications
immunological
allergy, ABO, TRALI
non immunological
fluid overload, infection, coagulopathy
metabolic
hypocalcaemia, hypomag, hyper hypokalaemia, metabolic alkalosis, hypothermia
