Blood Products

Question 1

Packed Red Blood Cells (PRBCs) Components:

Answer 1

RBCs

Question 2

Whole Blood Components:

Answer 2

RBC
WBC
Plasma
Platelet debris
Fibrinogen

Question 3

Fresh Frozen Plasma Components:

Answer 3

All coagulation factors
Fibrinogen
Plasma proteins

Question 4

Platelets Components:

Answer 4

Platelets

Question 5

Cryoprecipitate Components:

Answer 5

Fibrinogen
Factor 8
Factor 13
von Willinbrand’s Factor

Question 6

PRBC Indications:

Answer 6

RBC replacement (increase CaO2)

Question 7

Whole Blood Indications

Answer 7

RBC replacement/blood volume replacement (rarely used in OR)

Question 8

FFP Indications:

Answer 8

Coagulopathy (PT or PTT > 1.5x control)
Warfarin reversal (acute need)
Antithrombin 3 deficiency
Massive transfusion
DIC
C1 esterase deficiency (heredity angioedema)

Question 9

Platelets Indications:

Answer 9

Thrombocytopenia (<50,000 - invasive procedures, neuraxial blocks, most surgeries)
Thrombocytopenia (<100,000 - eye and neurosurgery)
Qualitative platelet defect
(highest risk of bacterial contamination)

Question 10

Cryoprecipitate Indications:

Answer 10

Fibrinogen deficiency (<80-100)
vWB disease
Hemophilia

Question 11

FFP doses:

Answer 11

Warfarin reversal: 5-8 mL/kg

Coagulopathy: 10-20 mL/kg (increases factor concentration by 20-30%)

Question 12

Cryoprecipitate dose:

Answer 12

5 bag pool increases Fibrinogen by 50 mg/dL