Board Vitals Questions Flashcards

(633 cards)

1
Q

What meds are FDA approved to treat bipolar depression?

A

Seroquel
Latuda
Zyprexa + Prozac

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are Standard Deviations?

A

68-95-99.7

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Sleep Stages

A

Stage 1 - 5%
State 2 - 50% (sleep spindles and K-complexes on EEG)
Stage 3 - 10-20% (deep/delta)
REM - 20-25% (dreams)
Non-REM/REM alternate every 90-100 - REM periods become increasingly longer as the night progresses

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

TCAs and seizures

A
  • lower sz threshold

- levels may inc w/sz meds

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

metabolic monitoring for antipsychotics

A

fasting blood glc - baseline, 12wk, annual
BP - baseline, 12wk, annual
BMI - baseline, 4wk, 8wk, 12wk, quarterly
waist circum - baseline, annual
fasting lipid - baseline, 12wk, 5yr

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

ECT modalities

A
bilateral
unilateral non dominant (right) - fewer cognitive SEs, less sx reduction
(no absolute contraindications)
6-10 sessions
3x/wk
1 sz/session
25 second sz

can switch from uni to bilateral after 4-6 treatments if no improvements

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Williams syndrome

A
ADHD
elfin facies
starburst facies
IDD
cheerful demeanor
ease with strangers
heart & blood vessel problems
strabismus
hypermuscularity
hyperacusis (sensitivity to sounds)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

autism spectrum disorder

A

1%
communication
social interaction
restriction of activities

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

childhood onset fluency disorder

A

5%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

vagus nerve stimulation

A

FDA approvals

  • epilepsy
  • treatment resistant depression

placed in carotid sheath

thoracic/abdominal viscera - medulla

4 failed trials

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

ADHD

A

9%

2: 1 male:female (kids)
1. 6:1 male:female (adults)

adult cut off 5 sx (of 18)
kid cut off 6 sx
6mths
prior to age 12

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

ADHD + tics

A

clonidine

guanfacine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

stimulant max doses (kids)

A

dexmethylphenidate (Focalin) 20mg
Methylin, Ritalin, Metadate 60mg
methylphenidate-OROS (Concerta) 72mg
methylphenidate patch (Daytrana) 30mg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

meds to avoid w/ECT

A

theophylline - prolongs szs
hypoglycemincs (insulin/orals)
beta blockers - asystole
lidocaine - reduce sz induction

lithium - prolong sz and confusion/postictal delirium
clozapine (late appearing sx)
bupropion (late appearing sx)

benzos (anticonvulsant)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

basilar migraine

A
transient headache
occipital pain
aura
quadriplegia (stroke like)
stupor
psychosis
blindness
coma
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

serotonin syndrome

A

clonus
tachycardia
hyperthermia

leukocytosis
rhabdomyolysis
abnormal LFTs
hypocalcemia
hyponatremia
hypomagnesemia

myoglobin - test for rhabdo

cocaine inhibits reuptake of serotonin

amphetamines
dextromethorphan
MDMA (ecstasy)
St. Johns wort
nefazodone
meperidine (Demerol)
fentanyl
antiemetics
carbamazepine
antimigraine meds
l-tryptophan
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Korsakoff’s syndrome

A

thiamine deficiency

anterograde and retrograde amnesia
confabulation
apathy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

herpes simplex encephalitis

A

temporal lobe
inferomedial frontal lobe

personality/behavior change
psychosis
gustatory & olfactory hallucinations
anosmia

xanthochromia
PLEDS (periodic lateralized epileptiform discharges) on EEG

IV acyclovir

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

anterior pituitary

A
FSH
LH
ACTH
TSH
Prolactin
Endorphins
GH
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

brain cell types

A

neurons

glia

  • astrocytes
  • microglia (act like macrophages)
  • macroglia
  • -oligodendrocytes (insulate axons in CNS w/myelin sheath)
  • -astrocytes (BBB, repair/scarring)
  • -ependymal cells (line ventricles and help produce CSF)
  • -radial glia (primary progenitors - neurons, astrocytes, oligos)
  • -Schwann cells (myelinated nerves in PNS)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

adrenoleukodystrophy

A

x-linked

accum. very long-chain fatty acids (VLCFA)
- myelin of CNS and adrenal cortex

mutations in ABCD1

vision & hearing impairment
aphasia
hyperactivity
paralysis
seizures
muscle weakness
adrenal failure
coma
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

left parietal lobe

dominate

A

Gerstmanns syndrome

right-left confusion
agraphia
acalculia
aphasia
agnosia (inability to interpret sensations)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

right parietal lobe

non dominate

A

dressing apraxia
difficulty understanding how things relate in space

left hemineglect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Brocas area

A

left frontal lobe

expressive aphasia

  • understand what is being said
  • difficulty forming spoken words

impaired naming and repetition

production of speech

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Wernickes area
left temporal lobe receptive aphasia - unable to comprehend spoken language - can still speak fluently (doesn't make sense) language development comprehension of speech
26
Huntingtons disease
caudate and putamen chromosome 4 CAG trinucleotide repeat anticipation huntington - synaptic vesicle-associated protein - accum. of intracellular toxic proteins - degeneration of striatum tx: tetrabenzazine haldol - chorea
27
Creutzfeldt-Jakob disease
Real Time Quaking Index Conversion (RT-QuIC) 6-9mth mortality CSF assay - tau proteins periodic sharp wave complexes (PSWCs) on EEG depression anxiety irritability insomnia
28
temporal lobe
hearing naming visual recognition facial recognition (fusiform gyrus)
29
parietal lobe
integrating sensory information IQ
30
occipital lobe
primary visual cortex?
31
frontal lobe
executive functioning social conduct judgment insight
32
tabes dorsalis
dorsal columns untreated syphilis ``` sensory ataxia lightening pains urinary incontinence paresthesias diminished/absent reflexes hearing impairment ``` ``` (neurosyphilis) dementia personality change confusion irritability depression visual disturbance Argyll Robertson pupils (accommodate but don't react to light) ```
33
endarterectomy
>70% blockage
34
B12 deficiency
``` megaloblastic anemia (MCV >100) GI sx neurologic sx -dementia -numbness -depression -muscle weakness ``` ``` pallor paresthesias decreased reflexes irritability poor concentration ``` posterior and lateral columns can be caused by nitrous oxide abuse
35
cryptococcal meningitis
AIDS encapsulated organism India ink test Amphotericin B
36
hippocampus
medial temporal lobe
37
alcohol-induced sleep disorder
early sedative effect deep sleepiness for 3-4hrs increased wakefulness more restless sleep for several hrs
38
absence seizures
3-4Hz spikes and slow wave complexes
39
coma/encephalopathy
diffuse or anteriorly prominent theta and delta patterns
40
MAOIs
``` serotonin, NE, dopamine sexual side effects weight gain orthostatic hypotension edema insomnia ``` - ine (also TCAs) - ide (also TCAs) - id - ane - ole - one ``` hydrazine Isocarboxazid nialamide phenelzine hydracarbazine tranylcypromine bifemelane moclobemide pirlindole toloxatone rasagiline selegiline (MAOI-B - dopamine only) safinamide ```
41
parasomnias
earlier phases of sleep slow phase sleep 10-30% kids - sleep walk 50% kids w/sleepwalking or night terrors develop OSA
42
myasthenia gravis
antibodies bloc, destroy or inactive postsynaptic neuromuscular acetylcholine receptors thymoma worsens w/exertion ``` diplopia dysarthria dysphagia fatigue muscle weakness ``` edrophonium chloride - Tensilon test (used to diagnose) ``` pyridostigmine plasmapheresis IVIG thymectomy steroids ```
43
Lambert-Eaton syndrome
impaired release of presynaptic acetylcholine repetitive muscle exertion may temporarily correct sx
44
botulism
impaired release of presynaptic acetylcholine botulism toxin blocks release of acetylcholine
45
REM sleep behavior disorder
15% Parkinsons 70% multiple system atrophy 85% Lewy body dementia
46
myotonic dystrophy
``` muscular dystrophy cataracts heart conduction defects endocrine changes myotonia hypersomnia frontal hair loss facial/temporal wasting problems w/executive functioning ``` involuntary contractions w/percussion of muscle ``` autosomal dominant trinucleotide repeat (CTG) ```
47
TCA overdose
<2 hrs - activated charcoal >2hrs - IV sodium bicarbonate (never induce emesis) intubate IV fluids cardiovascular toxicity (widened QRS)
48
cortical blindness
Anton's syndrome deny blindness despite clinical evidence bilateral occipital lobes
49
dementia
``` Alzheimers 60% vascular 15-30% Lewy body 4% frontotemporal 2% Parkinsons 2% all other causes 3% ```
50
Binswangers disease
dementia ``` 2 of the following: hypertension/vascular disease cerebral vascular disease subcortical dysfunction -neurogenic bladder -muscular rigidity -gait abnormalities bilateral abnormalities of MRI/CT syncope pseudobulbar palsy ```
51
lead poisoning
``` hypochromic microcytic anemia (MCV <80) lead line in mucosa irritability seizures coma wrist-drop foot-drop peripheral neuropathies hypertension depression ```
52
limbic system
smell | emotion
53
hydrocephalus
``` dementia amnesia decreased psychomotor movement magnetic gait incontinence ```
54
Meige's syndrome
tightly blinking eyes grimacing botox injections
55
thalamus
impaired visual memory (right) language deficits (medial) mood and sleep-wake-cycle (arterial and medial)
56
mammillary bodies
posterior diencephalon lesions: psychosis memory deficits confabulation
57
amygdala
``` behavioral issues emotional issues hypersexuality hyperorality hyperplasia ```
58
opioid intoxication
``` mitosis (constricted pupils) dec respiration dec bowel sounds nausea vomiting severe itching ``` naloxone
59
entacapone/tolcapone
catechol-O-methyltransferase (COMT) inhibitor helps prevent degradation/metabolism of levodopa and dopamine used in PD to reduce peripheral adverse effects of levodopa (has no actions by itself)
60
cluster headaches
``` young males episodic 15 mins - 3hrs nocturnal retroorbital ipsilateral autonomic sx ``` pts prefer moving their head or pacing high flow oxygen triptans (abortive) corticosteroids (bridging) verapamil (prophylaxis)
61
ethosuximide
absence seizures can cause hyperactivity reduces low threshold T-type calcium channels valproic acid is 2nd choice
62
schizophrenia
``` 1% 10% suicide risk 80% 5yr relapse w/o meds 40% 1yr relapse on meds women:men 1:1 chromosome 22 ``` active phase 1mth late onset after 45
63
sleep changes w/MDD
``` prolonged sleep latency inc wake time after sleep onset inc early morning awakenings dec total sleep time dec slow wave sleep dec slow wave sleep as % of total sleep time reduced REM latency prolongation of 1st REM sleep period inc REM activity inc REM sleep % ```
64
sleep changes w/GAD
longer sleep latency inc freq of awakenings normal REM latency
65
mesencephalon
(midbrain) dopamine production -substantia nigra
66
diencephalon
``` (interbrain) hypothalamus -control of hormone release -temperature regulation -sexual instincts -control of circadian rhythms (ventrolateral preoptic nucleus VLPO) -hydration ```
67
tuberomammillary nucleus
histamine arousal promoting itching
68
nucleus basalts of Meynert
acetylcholine sweating
69
raphe nuclei
serotonin nausea
70
locus coeruleus
norepinephrine arterial vasoconstriction
71
ventral tegmental area
substantia nigra | -dopamine
72
pheochromocytoma
norepinephrine sympathetic hyperactivity urine vanillyl mandelic acid (VMA) urine metanephrines adrenal mass
73
anti-NMDA receptor encephalitis
young women follows flu-like illness ovarian teratomas paraneoplastic syndrome ``` psychosis anterograde amnesia hallucinations suicidal ideation dyskinesias autonomic instability ```
74
drug induced Parkinsonism
remove offending agent
75
alpha-synucleinopathy
Parkinsons multiple system atrophy Lewy body dementia
76
tauopathy
Alzheimers | Picks disease
77
cholinesterase inhibitors
reversible donepezil rivastigmine galantamine tacrine start early continue indefinitely may reduce rate of cognitive decline GI side effects - nausea - vomiting - diarrhea - abdominal cramping - improve w/time
78
medial longitudinal fasciulus
conjugate eye movement
79
HARP syndrome
Hypobetalipoproteinemia (low cholesterol) Acanthocytosis (speculated red blood cells) Retinitis pigmentosa (pigment deposits on retina - loss of vision) Pallidal degeneration
80
atonic seizures
slow spikes and waves | or polyspikes and waves
81
hyper somnolence disorder
sleepiness despite 7 hrs in main sleep period at least 3x/wk for 3mths
82
NMDA-receptor antagonist
moderate-severe dementia memantine
83
delirium
12-40% geriatric pts 10-15% all pts 37% post op pts 22-33% 3mth mortality rate generalized slow wave and theta/delta waves on EEG
84
sleep
adolescence - stage 3 and 4 peak newborns - 50% REM number of awakenings and amount of"light" stage 1 sleep inc in later adulthood
85
narcolepsy
3x/wk for 3mths cataplexy and/or intrusion of REM sleep into transition between wake/sleep hypnopompic and hypnagogic hallucinations low levels CSF hypocretin (orexin) sodium oxybate (Xyrem) methylphenidate (Ritalin) modafanil (Provigil) structured napping times during the day
86
carbidopa/levodopa
levodopa - converted to dopamine in CNS and peripherally carbidopa - reduces peripheral conversion into dopamine (reducing side effects) -inhibits DOPA decarboxylase
87
pons
arousal sleep-wake cycles memory language
88
brain mets
most common - non-small cell lung cancer greatest risk to metastasize - melanoma and small cell lung cancer breast (? 2nd) renal GI cancers
89
amaurosis fugax
brief loss of vision black curtain coming down internal carotid artery
90
paroxysmal hemicrania
several headaches in 1 day short (2-30mins) lacrimation conjunctival inaction neck movements trigger episodes women responsive to indomethacin
91
anticipation
more trinucleotide repeats = earlier age of onset of sx Huntingtons (CAG) Friedrich ataxia myotonic dystrophy
92
Sydenham's chorea
group A strep kids girls OCD traits irritability restlessness 20-30% pts rheumatic fever
93
lower sx threshold
SSRIs = safe | ``` bupropion venlafaxine TCAs? amoxapine clomipramine maprotiline ```
94
trigeminal neuralgia
radiating jaw pain electric, shock like pain worsened by cold worsened by trivial stimuli (touching) carbamazepine phenytoin gabapentin (no NSAIDs)
95
Erickson's stages
``` 0-2 yrs trust vs mistrust 2-4 yrs autonomy vs shame/doubt (toilet training) 4-5 yrs initiative vs guilt (starting school) 5-12 yrs industry vs inferiority 13-19 yrs identity vs role confusion 20-39 yrs intimacy vs isolation 40-64 yrs generatively vs stagnation 65-death ego integrity vs despair ```
96
Piaget's stages
cognitive development birth-2 yrs sensorimotor -object permanence 2-6 yrs pre-operational - egocentrism - rules are fixed - ability to use symbols and language 7-11 yrs concrete operational - conservation of liquids - logic and objectivity - reversibility - transitivity - classification 11yrs-adult formal operations - abstract - hypothetical - major principles - motivations
97
kleptomania
naltrexoine fluoxetine SSRIs no meds FDA approved
98
operant conditioning
positive reinforcement -add desirable stimulus to increase desired behavior positive punishment -add undesirable stimulus to decrease undesired behavior negative reinforcement -remove undesirable stimulus to increase desired behavior negative punishment -remove desirable stimulus to decrease undesired behavior
99
play types
2 yrs - parallel play 3 yrs - associative play 4 yrs - cooperative play
100
Freud's stages
``` birth-18 mths oral 18 mths-3 yrs anal 3-5 yrs phallic 5-12 yrs latency 12-15 yrs genital ```
101
Tourettes
``` haldol pimozide Abilify botox clonidine ``` Seroquel worsens tics
102
Wernicke encephalopathy
acute phase of Korsakoffs syndrome medical emergency thiamine deficiency confusion ophthalmoplegia ataxia nystagmus delirium amnesia microhemorrhages in periventricular grey matter around ventricles give thiamine BEFORE glucose to avoid worsening of sxs
103
Mahler's stages
autistic phase (first weeks) - total detachment - self-absorption symbiotic phase (until 5mths) - recognizes mother - lacks sense of individuality seperation-individuation - hatching (differentiation?) - shows increased interest in outside world - practicing (9-16mths) - develops ability to separate from mother - rapprochement (15-24mths) - explores outside world, but requires mother is present and able to support appropriately and emotionally in completing the task object constancy (2-5yrs)
104
Kohlbergs developmental theories
3 levels of moral reasoning preconventional conventional postconventional
105
ADHD scales
Connors Index Scale SNAP-IV Rating Scale-Revised Vanderbilt Diagnostic Rating Scale
106
identification
pts w/conversion disorder exhibit sxs similar to someone important to them
107
conversion disorder
subconscious 1-3% of pts w/neuro sis neurologic sxs not solely limited to pain ``` young females low SES rural areas not well-educated lack of concern about sxs ```
108
factitious disorder
pt feigns sxs in order to seek the sick role
109
malingering
pt feigns sxs for secondary gain
110
personality disorders
cognition affectivity interpersonal functioning impulse control 15% population ``` antisocial - males (1% females) borderline - females histrionic - females dependent - female/neutral avoidant - female/neutral schizoid - male/neutral ```
111
schizoid
pervasive pattern of detachment from social relationships restricted range of emotions
112
schizotypal
3% population pervasive pattern of social and interpersonal discomfort with and reduced capacity for close relationships cognitive or perceptual distortions and eccentricities relatives w/schizophrenia
113
constraint
how easily an individual acts on an initial, emotionally based evaluation of events and people foundation of conscientiousness
114
self-system
stable and realistic sense of self
115
social system
means of interpreting social situations and understanding the relational motives and actions of others
116
self-in-relation system
capacity to observe the self as it relates to others
117
narcissistic personality disorder
caused by inadequate soothing in Mahler's symbiotic phase (up to 5mths) and inadequate refueling during separation-individuation (6-24mths) psychoanalysis (Kohut, Kernberg) group therapy
118
borderline personality disorder
2-3% population 12-15% clinical settings caused by disruption of Mahler's rapprochement (15-24mths) acting out splitting SSRIs antipsychotic mood stabilizer DBT mentalization based therapy
119
sublimation
take negative stimulus and associated appropriate emotional response and instead convert negative response into a positive and often productive response
120
interpersonal therapy
12-16 weeks relaxed/supportive beginning - 1-3 sessions (identify target diagnosis and interpersonal context in which it presents) middle (specific strategies) end - 1-3 sessions focuses on improving relationships in the present (not on what causes sxs) negative interpersonal experiences lead to depression induction of sick role explaining cause of pt's interpersonal problems (beginning phase) complicated bereavement -grief after loss of loved one role dispute -conflict in significant relationships role transition -difficulties adapting to change in relationships or life circumstances interpersonal deficits -difficulties stemming from social isolation or lack of life events (absence of one of the other 3)
121
psychodynamic therapy
focuses on unconscious motivations
122
aversive conditioning
using punishment to decrease target behavior
123
habituation
learning response that decreases over time as same stimulus is repeated
124
extinction
decrease in conditioned response due to lack of reinforcement
125
continuous reinforcement
reward is given every time the target response occurs
126
law of effect
responses that produce a satisfying effect in a particular situation are more likely to occur again in that situation response that produce a discomforting effect are less likely to occur
127
negative practice
reducing a behavior by repeating the response intensely
128
modeling/observational learning
behavior that is learned by watching others
129
paranoid personality disorder
individual psychotherapy not overly warm 10-30% psych inpatients
130
tertiary prevention
prevent deterioration or reduce complications of disease ACT metabolic monitoring intensive case management
131
secondary prevention
detects diseases early when pts are asymptomatic HIV testing screening prodromal schizophrenia
132
primary prevention
keeps disease from occurring by removing its causes lifestyle changes immunizations suicide prevention programs
133
privilege
possessed by the individual patient, not the patient
134
hydrazine
MAOI
135
Isocarboxazid
MAOI
136
nialamide
MAOI
137
phenelzine
MAOI
138
hydracarbazine
MAOI
139
tranylcypromine
MAOI
140
aphasia vs dysarthria
aphasia - disturbance of language (cognitive function) dysarthria - disturbance of speech (motor function)
141
scanning
slurred speech with variable cadence and volume cerebellum
142
dysdiadochokinesia
impaired ability to perform rapid, alternating movements cerebellar damage
143
T10
sensation below umbilicus spastic leg weakness
144
Foster-Kennedy syndrome
depression frontal lobe tumor optic nerve compression optic atrophy papilledema
145
chromosome 1
alzheimers disease | presenillin 2
146
chromosome 3
von Hippel-Lindau syndrome
147
chromosome 4
Huntington disease | Parkinson disease alpha-synuclein gene
148
chromosome 5
infantile and juvenile spinal muscular atrophy | Werdnig-Hoffma and Kugelberg-Welander diseases
149
chromosome 6
Creutzfeldt-Jakob disease Parkinson disease, Parkin spinocerebellar ataxia type 1
150
chromosome 7
Williams syndrome
151
chromosome 9
dystonia (early-onset primary dystonia - DYT1) Fredreich ataxia tuberous sclerosis complex 2
152
chromosome 12
phenylketonuria
153
chromosome 13
Wilson disease
154
chromosome 15
Angelman syndrome dyslexia Prader-Willi syndrome Tay-Sachs (hexosaminidase A deficiency)
155
chromosome 16
tuberous sclerosis complex 2
156
chromosome 17
Charcot-Marie-Tooth disease frototemporal lobar degeneration Narcolepsy-cataplexy neurofibromatosis type I
157
chromosome 19
apolipoprotein E familial hemiplegic migraine malignant hyperthermia susceptibility myotonic dystrophy
158
chromosome 20
fatal familial insomnia
159
chromosome 21
homocystinuria myoclonic epilepsy trisomy 21
160
chromosome 22
``` metchromatic leukodystrophy neurofibromatosis type 2 velocardiofacial DiGeorge syndrome schizophrenia ```
161
x chromosome
``` adrenoleukodystrophy Duchenne muscular dystrophy Fragile X syndrome Lesch-Nyhan syndrome Rett syndrome ```
162
CGG
Fragile X syndrome x linked sex linked
163
GAA
Friedreich ataxia chromosome 9 autosomal recessive
164
CAG
Huntingtons disease - chromosome 4 - autosomal dominant spinocerebellar atrophies - autosomal dominant - type 1 (chromosome 6) - type 2 (chromosome 12) - type 3 (chromosome 14)
165
CTG
myotonic dystrophy chromosome 19 autosomal dominant
166
GCC
oculopharyngeal dystrophy chromosome 14 autosomal dominant
167
atropine/scopolamine
blocks cerebral acetylcholine receptors delirium amnesia anticholinergic effects
168
organophosphate insecticides/nerve gas
inhibit cholinesterase (irreversible) - increases acetylcholine - cholinergic toxicity postsynaptic dysfunction brief stimulation, then paresis of all muscles increased parasympathetic activity confusion seizures ``` Diarrhea Urination Miosis Bradycardia Emesis Lacrimation Salivation/sweating/secretion ``` tx: atropine + pralidoxime
169
upper motor neuron signs
``` weakness hyperreflexia tight muscles clonus Babinski sign ```
170
lower motor neuron signs
``` weakness areflexia paralysis atonia fasciculations ```
171
posterior columns
position and vibration fasciculus cuneatus fasciculus gracilis
172
lateral spinothalamic tract
pain and temperature
173
T4
nipples
174
anosognosia
lack of self-awareness of deficit
175
neuropathy vs myelopathy
neuropathy - damage to nerves outside the CNS myelopathy - damage to the spinal cord
176
Wisconsin card sorting test
executive functioning color, form, number
177
Boston naming test
anomia (unable to recall names of everyday objects)
178
operant conditioning scheduling
fixed-interval -reinforcement for response that occurs after set time fixed-time -reinforcement after fixed time, regardless whether behavior performed fixed-ratio -reinforcement every set number of responses variable interval - reinforcement for responses after varying amounts of time - response varies w/time (checking email throughout the day to monitor for important messages) variable ratio -reinforcement at a varying response rate (slot machines)
179
negative contrast
switched from high reward to low reward paradoxically weakens behavior more than simply receiving low reward all along
180
reinforce devaluation
subject denies previously positive reinforcer is no longer valued and cannot be used to strengthen behavior any longer
181
varenicline (Chantix)
partial agonist at alpha4beta2 full agonist at alpha 7 binds to receptors avidly, but stimulates receptors more weakly than nicotine, reducing cravings but also limiting the pleasurable effects of smoking
182
hypericum perforatum
St. Johns Wart antidepressant anxiolytic no (serotonin syndrome) - SSRIs - MAOIs
183
ginkgo biloba
improves memory | impairs anti platelet memory (causes bruising)
184
echinacea purpurea
improves immune system
185
lithium
cerebellar damage diabetes insipidus - polyuria (single bedtime dose) - polydipsia (single bedtime dose) - hypernatremia - treat w/amiloride (K sparing diuretic) hyperparathyroidism - decrease lithium clearance - increase lithium levels - -lisinopril - -NSAIDs - -HCTZ - -low sodium diet - decrease lithium level - -high sodium diet level not affected by aspirin insulin-like effect reduces affect of ADH on kidney
186
CYP 3A4 inducers
``` carbamazepine oxcarbazepine phenobarbital/barbiturates phenytoin oxcarbazepine ethosuxamide steroids progesterone St. John's wort rifampin (lots of r's) ```
187
CYP 3A4 inhibitors
``` (lots more) valproic acid nefazodone fluoxetine sertraline fluvoxamine amiodarone cannabinoids diltiazem entacapone erythromycin grapefruit juice omeprazole ranitidine ketoconazole ```
188
CYP 2D6 inhibitors
fluoxetine sertraline paroxetine duloxetine
189
spinal cord
ends at T12-L1
190
Brown-Sequard syndrome
hemitransection of thoracic spine (loss of pain sensation contralateral to paresis) ``` injury to lateral corticospinal tract= ipsilateral -leg paresis -hyperactive DTRs -Babinski sign ``` injury to posterior columns= ipsilateral -impairment in vibration and position sense (proprioception) injury to spinothalamic tract= contralateral -loss of temperature and pain sensation
191
cranial nerves
``` I Olfactory II Optic III Oculomotor IV Trochlear V Trigeminal VI Abducens VII Facial VIII Vestibulocochlear (Acoustic) IX Glossopharyngeal X Vagus XI Spinal XII Hypoglossal ```
192
spinocerebellar ataxia
``` posterior column abnormalities (sensory loss) Babinski sign limb ataxia scanning speech pes cavus ``` trineucleotide repeat chromosome 6 autosomal recessive
193
NRTs
(fastest to slowest) ``` tobacco cigarette spray (10-15mins) inhaler lozenge (20-30mins) gum (30-60mins) patch (2-9hrs) ``` short acting - 3mths
194
buspirone
5-HT1A partial agonist at postsynaptic receptors 5-HT1A full agonist at presynaptic receptors mild-moderate presynaptic D2, D3, D4 antagonist partial alpha1 agonist
195
mirtazapine
tetracyclic antidepressant - alpha-2 adrenergic antagonist - increases release of. norepinephrine - histaminic antagonism - -sedation - -inc appetite - -weight gain - 5-HT3 antagonist (anti-nausea) - (also 5-HT2 antagonist)
196
atomoxetine
norepinephrine reuptake inhibitor
197
carbamazepine
``` SIADH hyponatremia elevated LFTs hepatitis decreased WBCs agranulocytosis pancytopenia aplastic anemia Stevens-Johnson ``` check LFTs blockage of type 2 sodium channels
198
lamotrigine
cleft lip cleft palate lower dose w/valproate
199
valproate
neural tube defect 20-30mg/kg loading dose increased by: - cimetidine - macrolide abx (erythromycin) - felbamate decreased by: - carbamazepine - phenytoin - primidone - phenobarbital ``` pancreatitis increased amylase tremor alopecia ankle swelling thrombocytopenia hepatic failure (BLACK BOX) ```
200
glutamate
excitatory precursor to GABA learning memory receptors - AMPA - NMDA - kainate
201
acute intermittent porphyria
``` confusion hallucinations flaccid paresis abdominal pain red urine ``` Watson-Schwartz test contraindicated (can precipitate/worsen attack) - barbiturates - phenytoin
202
bupropion
dopamine-norepinephrine reuptake inhibitor
203
tardive dyskinesia
all typicals 5%/yr 10-20% treated for more than a year 20-40% hospitalized long term women children elderly brain damage less - seroquel - clozaril - geodon
204
buprenorphine-naloxone
buprenorphine - partial agonist at mu-opiod receptor - antagonist at kappa-opioid receptor naloxone -antagonist at mu-opiod receptor
205
hypnotic half life
shortest to longest ``` zaleplon (Sonata) ramelteon (Rozerem) zolpidem (Ambien) / triazolam (Halcion) eszopiclone (Lunesta) temazepam (Restoril) ```
206
CYP450 inhibitor
valproate fluoxetine fluvoxamine sertraline
207
CYP450 inducer
phenytoin carbamazepine phenobarbital rifampin
208
clozapine
neutropenia myocarditis eosinophilic colitis fluvoxamine - inc clozapine levels dopamine, serotonin, alpha antagonist
209
Xyrem (sodium oxybate)
narcolepsy GABA-B
210
false positives
``` venlafaxine - PCP amitriptyline - LSD naproxen - barbiturates sertraline - benzos trazodone - amphetamine ```
211
panic disorder
1mth sertraline fluoxetine paroxetine CBT
212
oral contraceptives
carbamazepine - dec OCPs oxcarbazepine - dec OCPs topiramate >200mg
213
seizure threshold
``` bupropion clozapine theophylline clomipramine clozapine ``` alcohol cocaine stimulants
214
SSRIs
inc risk of bleeding - reduction of serotonin in plts GI SEs most common in sertraline and fluvoxamine (5HT-3) CNS activation (anxiety, restlessness, tremor, insomnia) most common in fluoxetine sedation most common in paroxetine SIADH most common in fluoxetine akathisia/EPS rare - most common in sertraline
215
GAD
venlafaxine paroxetine escitalopram duloxetine
216
ginseng
can interact with - phenelzine - lithium - neuroleptics can cause - irritability - insomnia - mania
217
pyroxidine
vit B6 deficiency - MAOIs - isoniazid (INH)
218
nefazodone
black box warning - liver failure - suicidality hypotension bradycardia
219
kava kava
sedative anesthetic consumed as a beverage should not be used w/benzos, alcohol or barbiturates liver toxicity
220
cyp 2D6 inducer
dexamethasone | rifampicin
221
couples therapy
behavioral exchange communication training problem solving
222
interpersonal therapy
communication analysis - (identify maladaptive communication patterns to help pt communicate effectively) construct a timeline - understand relationship between depression and interpersonal experiences treats depression focuses on current relationships 4 core issues - grief - role transition - role dispute - interpersonal deficits
223
depressive disorder therapy
IPT | CBT
224
psychodynamic therapy
working through - identify patterns of defense mechanisms and object relations - make the subconscious conscious
225
cognitive behavioral therapy
``` most widely used depression anxiety schizophrenia not personality disorders ``` identification of dysfunctional cognitions role playing thought mood logs automatic thoughts exposure and response therapy
226
dialectical behavioral therapy
assumes pts are doing the best they can, and they need to do even better chain analysis patient capabilities group skills training individual therapy phone consultations consultation team
227
Lazarus coping - model for stress management
self exploration self instruction self correction self rehearsal
228
anorexia
``` hypokalemia elevated BUN hypercholesteremia hyperamylasemia hypomagnesemia hypophosphatemia ``` cardiac arrhythmias osteoporosis lanugo female adolescent perfectionistic
229
prochlorperazine
phenothiazine typical antipsychotic nausea vomiting vertigo
230
eszopiclone
Lunesta short acting daytime sleepiness fatigue taste disturbance
231
Jean Baker Miller
relational theory
232
Sigmund Freud
structural theory
233
Anna Freud
ego psychology | defense mechanisms
234
Carl Jung
transpersonal psychology analytic psychology growth of personality
235
Melanie Klein
object relations theory bad mother tension between true and false self paranoid-schizoid position - parts of mother as all good or all bad depressive position - mother ambivalent, having both positive and negative aspects
236
Kohut v Kernberg
Kohut (self psychology) - self-object - supportive - transference - -mirroring (affirming/positive responses used to see positive responses in self) - -idealization (calm and soothing other provides comfort when unable to do so for self) Kernberg - confronting - defenses - -splitting - -projectice identification - -primitive idealization
237
supportive therapy
reduce symptoms improve self-esteem and functioning therapist makes suggestions and gives advice
238
Kurt Schneider
first rank symptoms
239
Eugene Bleuler
coined the term schizophrenia ``` the 4 As loose Associations Affective flattening Autism Ambivilance ```
240
Emil Kraeplin
used the term dementia praecox (created by Morel) classified schizophrenia as a physical disease differentiated schizophrenia from manic-depressive illness
241
assertiveness training
behavioral therapy avoidant personality disorder
242
neurosis
unconscious conflict between opposing wishes or between wishes and prohibitions
243
abreaction
process that occurs when repressed memory and associated affect is brought into consciousness
244
Josef Breuer
contemporary and friend of Freud helped develop theory of hysteria
245
Salvador Minuchin
structural family therapy
246
medial frontal lobe lesion
apathy | limited spontaneous movement, gesture, speech
247
left frontal lobe lesion
depression Broca's area?
248
right frontal lobe lesion
mania
249
ailurophobia
dread of cats
250
cohort study
follow population over period of time longitudinal study
251
case-control study
retrospective | examines persons without a particular disease
252
clinical trial
some patients get treatment another group does not assigned randomly goal to determine effectiveness of treatment
253
cross-sectional survey
describe prevalence in a population at a particular point in time
254
crossover study
variation of double-blind | placebo and treatment groups switch at some point
255
Winnicott
good enough mothering transitional object
256
SSRI to MAOI
14 day washout | 28 day for fluoxetine
257
resistance
ideas that are unacceptable to the pt are prevented from reaching awareness
258
Guillain-Barre syndrom
acute inflammatory demyelinating polyneuropathy (AIDP) campylobacter jejnui ascending pain paralysis seonsory loss loss of DTRs in extremities IVIG plasmapheresis
259
polymyositis
inflammatory disease of the muscle
260
amyotrophic lateral sclerosis (ALS)
upper and lower motor neurons damage to anterior horn cells progressive muscle weakness fasciculations wheelchair bound
261
Bandura
social learning theory learn through modeling others and social interaction
262
Seligman
learned helplessness organism learns that no behavioral change can influence the environment organism becomes depressed and apathetic
263
insomnia disorder
difficulty initiating or maintaining sleep 3x/wk for 3 maths
264
GABA
major inhibitory neurotransmitter chloride ion channel
265
glycine
inhibitory
266
tuberous sclerosis
autosomal dominant seizures mental retardation behavioral problems cutaneous lesions facial angiofibromas shagreen spots (irregularly shaped skin lesions on back and flank) retinal haratomas
267
Rett's disorder
girls only ``` deceleration of head growth loss of purposeful hand skills stereotyped hand movements loss of social engagement acquired impairments in expressive and receptive language skills seizures ```
268
executive function tests
trail making test | Wisconsin card sorting test
269
bromocriptine
prolactinomas | NMS
270
thought content
``` delusions obsession compulsions phobias suicidality homicidality neologisms depersonalization derealization ```
271
thought process
``` racing thoughts circumstantial tangential clang associations perseveration word salat goal directed ideas ```
272
MSE perception
hallucinations
273
amok
Malaysa sudden rampage homicide/suicide ends in exhaustion/amnesia
274
koro
Asian delusion penis will disappear into abdomen and cause death
275
piblokto
female Eskimos ``` anxiety depression confusion depersonalization derealization ending in stuporous sleep/amnesia ```
276
wihtigo
Native Americans delusional fear of being turned into a cannibal through possession by a supernatural monster (the Wihtigo)
277
mal de ojo
Mediterranean vomiting fever restless sleep caused by the evil eye
278
Hoffman sign
flick middle finger + if other fingers/thumb involuntarily flex + = upper motor neuron damage
279
palomental reflex
+ when chin muscle contracts when thenar eminence contralateral to brain lesion is stroked upper motor neuron damage
280
loss of gag reflex
devastating stroke to brain stem | brain death
281
Meyerson's sign
glabeller reflex repeated blinking when tapping on forehead possible Parkinsons
282
brain death
absence of brain stem reflexes - absent gag - fixed pupils - absent oculocephalic reflex - absent oculovestibular reflex - absent corneal reflex eyes can be open or closed EEG doesn't have to be flat line (it's all about the brain stem)
283
four horsemen of the apocalypse
relationship dissolution criticism defensiveness contempt stonewalling
284
Karen Horney
actual self real self idealized self social and cultural influences on psychosexual development
285
Maudsley model
family based therapy | anorexia
286
selective abstraction
taking a small detail out of context and using it to make an entire experience negative
287
arbitrary inference
coming to an incorrect conclusion based on a previous experience
288
dichotomous thinking
all or none | black or white
289
overgeneralization
coming to a generalized conclusion based on a single experience
290
magnification/minimization
making events more/less signification based on a negative interpretation
291
sublimation
socially unacceptable desire is consciously transformed into a socially acceptable one
292
motivational interviewing
Open ended questions Affirmations Reflective listening Summaries expression of empathy rolling with the resistance developing discrepancy supporting self-efficacy
293
OCD
group therapy | behavior therapy
294
conduct disorder
multi systemic therapy family focused community based
295
fetishistic disorder
obtains sexual arousal from an inanimate object at least 6 months
296
transvestism
sexual arousal from crossdressing (not just underwear, full outfits) usually heterosexual men
297
trigeminal neuralgia
brief, sharp pain worsened by cold unilateral carbamazepine oxcarbazepine
298
temporal arteritis
women: men 3:1 ``` elderly headache fever fatigue myalgia night sweats weight loss jaw claudication ``` irreversible and sudden vision loss ESR sed rate elevated prednisone
299
illness anxiety disorder
pt believes they have a specific serious disease despite negative (or "a serious dx") 6mths 1-5% population chronic waxing/waning
300
somatic symptom disorder
pt has one or more somatic symptoms that are distressing and disrupt daily life not intentionally produced not explained by medical dx (sx can be associated w/another medical condition) 6mths ``` lower level of edication lower SES female older age unemployed ``` tx: therapy only (group and individual)
301
fluvoxamine
shortest half life SSRI
302
dermatomyositis
autoimmune disease of skin and muscles skin rash on face, eyelids, elbows, knees carcinoma
303
good prognostic indicators of schizophrenia
acute onset mood disorder sx family hx of mood disorders positive sx
304
poor prognostic indicators of schizophrenia
``` male no precipitating factors withdrawn family hx of schizophrenia negative sx neurological sx hx of perinatal trauma no remissions in early years many relapses hx of assaultiveness ```
305
opioid withdrawal
clonidine phentolamine (HTN) dicyclomine (Bentyl)
306
burden of proof
preponderance of the evidence 50% - civil cases, competency reasonable medical certainty 50.1% - more likely than not - expert witness clear and convincing 75% - civil commitment beyond a reasonable doubt greater than 90% - criminal cases
307
gender
2yrs - gender constancy 3yrs - gender identity 5-7yrs - rigid/inflexible
308
Malan
triangle of conflict defense work forming a portrait to resolve dynamic pathologic defenses
309
Sifneos
anxiety provoking therapy | therapist acts as a teacher
310
Davanloo
intensive short-term dynamic psychotherapy
311
Mann
existential therapy | therapist acts as empathetic helper
312
partialism
oralism paraphilia only aroused by/can only achieve orgasm through a single type of sexual contact
313
klismaphilia
paraphilia sexual arousal from enemas
314
psychosexual factors
sexual identity patter of a person's biological sexual characteristics (usually no doubt about male vs female) gender identity a person's sense of maleness or femaleness sexual orientation who someone is attracted to sexually (male vs female vs both) sexual behavior who someone actually has sex with (male vs female vs both)
315
pedophiles
girls 8-10yrs | boys slightly older
316
Hwa-Byung
Korea similar to somatization do middle aged females psychosocial stress
317
TCA levels
desipramine imipramine nortriptyline all are cyp 2D6 substrates
318
PTSD
CBT more common in women 7.8% lifetime prevalance >1mth no way to predict who gets it no improvement w/debriefing decreased hippocampal volume FDA: sertraline paroxetine 2nd generation antipsychotics venlafaxine? other SSRIs? Benzos slow recovery rate
319
body dysmorphic disorder
risk factors - childhood neglect - abuse family hx - OCD - mood dos tx: - SSRIs - MAOIs - TCAs chronic body part may change
320
mental retardation
trisomy 21 - most common fragile X - 2nd most common, most common heritable
321
cocaine
blocks dopamine reuptake dopamine and NE reuptake inhibition increases dopamine?? ``` hyper sexuality shower of lights tactile hallucinations (coke bugs) hyperthermia (OD) hypertension (phentolamine) ``` crack coca freeze girl happy dust
322
dopamine agonist
can treat Parkinson's pergolide bromocriptine pramipexole ropinirole buspirone - partial agonist (???)
323
ziprasidone
inhibits serotonin and norepinephrine reuptake 5-HT agonist
324
aripiprazole
partial dopamine D2 agonist partial 5-HT 1A agonist 5-HT 2A antagonist (as are all atypicals)
325
prefrontal cortices
lesion to left - depression lesion to right - mania
326
Wilsons disease
autosomal recessive chromosome 13 incorporation of copper into ceruloplasmin diminished biliary excretion of copper excessive deposition of copper in the brain -basal ganglia serum ceruloplasmin ``` Parkinsonism flapping tremor ataxia dystonia dysphagia dysarthria liver failure ```
327
nucleus accumbens
reward center | also VTA
328
type 1 error
null hypothesis rejected when it should have been retained
329
type 2 error
null hypothesis retained when it should have been rejected
330
power
probability of finding the difference between two samples probability of rejecting the null hypothesis when it should be rejected
331
UDS
``` cocaine - 8hrs alcohol - 12hrs amphetamine - 48hrs heroin - 72hrs PCP - 8days cannabis - 4wks ```
332
bruxism
grinding teeth amphetamines MDMA (ecstasy)
333
cannabis
``` reddened conjunctivae tachycardia dry mouth orthostatic hypotension anxiety panic attacks ```
334
MDMA (ecstasy)
bruxism dilated pupils tenting of skin serotonin reuptake inhibitor ``` ecstasy Adam club drug disco biscuits love drug ```
335
substance use disorder
mild 2-3 moderate 4-5 severe 6
336
methyl alcohol
encephalopathy ataxia visual loss tachypnea hemorrhage of putamen
337
alcoholic psychosis
alcohol withdrawal with AVH | clear sensorium
338
opioid withdrawal
``` N/V/D yawning perspiration runny nose dilated pupils twitching muscles ```
339
depressants
``` alcohol cannabis opioids inhalants benzos ```
340
stimulants
amphetamine | cocaine
341
hallucinogen
LSD MDMA cannabis
342
dissociative agent
PCP | ketamine
343
naltrexone
opioid antagonist
344
acamprosate
NMDA antagonist structurally resembles GABA reduces EtOH cravings tid dosing give after ~1wk no EtOH
345
disulfiram
aldehyde dehydrogenase inhibitor if drink EtOH, N/V/HTN/HA/flushing must abstain from alcohol for several days - 1 week prior to use (minimum 12hrs) 500mg qd x1-2wks then 250mg qd
346
LSD
increased body temp tachycardia hypertension dilated pupils
347
PCP
``` nystagmus agitation hypertension tachycardia diminished pain slurred speech ataxia muscle rigidity seizures hyperacusis (inc sensitivity to certain frequencies) catatonia ``` angel dust belladonna black whack use benzos for agitation NMDA antagonism
348
methamphetamine
``` crank crystal ice speed crystal meth ```
349
ketamine
``` cat valium special K vitamin K kit kat honey oil ``` derivative of PCP
350
alcohol metabolism
women - lower adjusted body water - higher fat content - lower alcohol dehydrogenase in gastric mucosae
351
methadone
initial dose 10-20mg | goal dose 60-100mg
352
n-Hexane
glue inhalant glue-sniffer neuropathy similar to Guillain-Barre sx bluish discoloration decrease temperature extremities facial numbness vision loss
353
onanism
masturbation | coitus interuptus
354
schizophreniform good prognostic features
psychotic sx with 4wks of noticeable changes confusion good fx prior to sx absence of flat affect
355
lateral geniculate nucleus
thalamic nucleus | visual/retina
356
ventral posteromedial nucleus
thalamic nucleus | face sensory
357
ventral posterolateral nucleus
thalamic nucleus | leg and arm sensory
358
ventral lateral nucleus
thalamic nucleus | cerebellar
359
medial geniculate nucleus
thalamic nucleus | auditory
360
Physostigmine
treats anticholinergic toxicity similar to NMS/serotonin syndrome lack of diaphoresis
361
risk of schizophrenia
``` prenatal malnutrition radiation during 1st trimester maternal influenza during pregnancy family childhood stress winter/spring births ```
362
schizophrenia age of onset
men (mean 20-28) -10-25 women (mean 26-32) - early 20s - early 30s - early 60s
363
psychogenic polydipsia
high antipsychotic doses moderate anticholinergic doses extended hospitalization nicotine
364
clozapine myocarditis
first 1 mth fever flu like sx never rechallange
365
Benedict Morel
first coined dementia praecox
366
sensory gating
suppress information
367
cotard syndrome
pt feels like he/she is dead (or a zombie)
368
de Clerambault syndrome
erotomania
369
schizophrenia incidence
1% population 2.8-8.2% 1st degree relative 13% parent (10x) 40% monozygotic twin
370
schizophrenia brain
``` dec blood flow to frontal lobes brain volume deficit increased vol of lateral and 3rd ventricles and basal ganglia smaller hippocampus decreased activity in frontal lobes ```
371
catatonia
7-17% psychosis | 13-31% mood disorders
372
trifluioerazine
Stelazine | atypical antipsychotic
373
neuroleptic malignant syndrome
treat w/bromocriptine/dantrolene (if not responding to supportive care within 24-48hrs) increased muscle tone hyperthermia elevated CPK
374
Jacob Kasanin
schizoaffective disorder
375
brief psychotic disorder
less than 1 month
376
schizophreniform disorder
more than 1 month | less than 6 months
377
antipsychotic w/possible pregnancy risk
Risperdal
378
illusions
misinterpretations of actual stimuli hear a dog barking, but interpret it as a person saying something
379
odd EPS
abnormal postures difficulty talking drooling
380
CATIE trial
no difference in rates of hospitalizations and EPS between meds olanzapine highest metabolic effects clozapine most effective discontinuation rates all similar (longest was olanzapine, but most side effects) no difference between 1st and 2nd generation meds risperidone quetiapine ziprazidone perphenazine
381
antipsychotic sexual side effects
higher in women
382
antipsychotic doses
higher in postmenopausal women normal in men lower in premenopausal women
383
clozaril ANC
1,500 begin daily ANC monitoring until >1,000 (may then consider restarting)
384
completed suicide ration
male:female 3:1
385
tuberoinfundibulnar tract
dopamine prolactin amenorrhea galactorrhea hypothalamus to anterior pituitary
386
highest prevalence
anxiety disorders
387
pathological gambling
at least 5 ``` preoccupation w/gambling gambling increased sums of money attempts to quit gambling to escape dysphoric mood lying to SOs about gambling loss of important relationships illegal acts to be able to gamble relying on others to pay bills desire to keep going back to break even ```
388
internuclear ophthalmoplegia
MS | medial longitudinal fasciculus
389
rumination disorder
1mth
390
depersonalization
experience of unreality, detachment or feeling like an outside observer to your own body, actions, sensations, thoughts or feelings
391
derealization
experience of unreality or detachment to you own surroundings experienced as unreal, dream-like, foggy, lifeless or visually distorted
392
anosognosia
inability to recognize neurological deficit occurring in oneself
393
multiple sclerosis
most common inflammatory demyelinating disease onset 15-50yrs optic neuritis - eye pain increased w/movement - central visual loss (scotoma) - afferent pupillary defect (Marcus Gunn pupil) (swinging flashlight test) internuclear ophthalmoplegia fever worsens sxs (Uhthoff's phenomenon) fatigue Lhermitte's sign - electric shock down spine w/neck flexion steroids interferon
394
Russells sign
calluses on the back of the hands due to self induced vomiting bulimia
395
neurofibromatosis type I
``` six cafe-au-lait spots axillary/inguinal freckling optic glioma 2 or more neurofibromas 1st degree relative w/NF1 2 or more Lisch nodules (hamartomas of the iris) bony lesions ```
396
neurofibromatosis type II
bilateral acoustic schwannomas
397
thiamine
vitamin B1
398
alcohol use during pregnancy
1/3 - fetal alcohol syndrome inc risk of ADHD small for gestational age
399
binge eating disorder
extroverted SSRIs stimulants CBT
400
clozapine monitoring
ANC 1,000-1,499 - inc freq of monitoring to 3x/wk until 1,500 - then restart at last normal dose/ANC monitoring level ANC 500-999 - interrupt clozapine until level resolves - daily ANC until 1,000 - 3x/wk until 1,500 - then check weekly x4wks - then restart at last normal dose/ANC monitoring level ANC below 500 - stop clozapine - daily ANC until 1,000 - 3x/wk until 1,500 - may rechallange if ANC recovers (consider risks/benefits) - resume as new pt ``` baseline ANC ANC every wk x6mths ANC every 2wks x6mths ANC every mth forever ANC every wk x4wk after stopping ```
401
rapid correction of hyponatremia
central pontine myelinolysis acute locked in syndrome
402
pseudotumor cerebri
``` black fat fertile 30s OCPs tetracycline ``` visual field defects headaches waxing/waning lumbar puncture opening pressure over 20 acetazolamide
403
r-TPA
within 3hrs of stroke exclusion criteria - seizure - hemorrhage - major surgery past 3mths - glc abnormalities - recent MI - anticoagulants - thrombocytopenia
404
restless leg
ropinirole (Requip) | dopamine agonist
405
violence/aggression
decreased levels of serotonin in CSF dopamine - inc aggression serotonin/NE/GABA - dec aggression
406
metachromatic leukodystrophy
``` autosomal recessive chromosome 22 deficiency in arylsulfatase A (ASA) lysosomal storage disease death by age 5 ``` ``` gait disorder hypotonia lower limb areflexia dementia behavioral problems ```
407
seasonal affective disorder
not in DSM (with season pattern specifier in DSM) sx must remit during other seasons light therapy tx - carb cravings - most effective in AM - can precipitate hypomania
408
AIDS decreased visual acuity
cytomegalovirus
409
JC virus
AIDS ``` clumsiness progressive weakness visual changes speech changes personality changes ```
410
logorrhea
uncontrollable, excessive talking
411
alexithymia
difficulty recognizing and describing one's emotions
412
TCA side effects
``` constipation anticholinergic sxs orthostatic hypotension sedation tremor prolonged QTc & PR tachycardia ```
413
lumbar lesions
L1/L2/L3 - hip flexion L3/L4 - leg extension L5 - foot flexion S1 - foot extension, ankle jerk
414
pure motor hemiparesis
internal capsule lacunar stroke
415
pure sensory stroke
thalamus
416
pure sensorimotor stroke
internal capsule
417
histamine
weight gain | sedation
418
anticholinergic
``` constipation blurred vision dry mouth drowsiness urinary retention cognitive dysfunction ```
419
alpha 1 adrenergic
orthostatic hypotension | drowsiness
420
dopaminergic
antipsychotic effects EPS prolactin elevation
421
hemiballismus
contralateral subthalamus
422
biogenic amine NTs
``` dopamine epinephrine NE acetylcholine serotonine histamine ```
423
CSF
production -choroid plexus drainage into blood -arachnoid granulations
424
subacute sclerosing panencephalitis
measles ``` personality changes myoclonic seizures choreoathetoid movements difficulty swallowing death - 12mths ``` CSF assay (measles Ab) EEG brain biopsy
425
Lesch-Nyhan
x-linked recessive self-mutilation
426
duloxetine
contraindicated in liver disease withdrawal sx fibromyalgia
427
Mood Disorder Questionnaire
mania/hypomania screener
428
Epworth Sleepiness Scale
OSA
429
bipolar incidence
bimodal 15-24 45-54
430
social rhythm therapy
bipolar disorder
431
myxedema
depression psychosis hypothyroidism
432
mad hatter syndrome
mania | mercury intoxication
433
tetracyclic antidepressant
amoxapine (D2 antagonist) maprotiline mirtazapine
434
Sturge-Weber syndrome
``` port-wine nevus brain angioma ipsilateral to skin nevus contralateral hemiparesis MR homonymous meiagopia glaucoma seizures ```
435
cyp 3A4 substrates
``` erythromycin clarithromycin alprazolam diazepam midazolam cyclosporine diltiazam nifedipine amlodipine verapamil atorvastatin simvastatin aripiprazole buspirone haloperidol tamoxifen trazodone propranolol zolpidem zaleplon methadone OCPs progesterone testosterone fentanyl ```
436
cigarette smoke
lowers levels of ``` amitriptyline fluvoxamine clozapine olanzapine haloperidol imipramine ```
437
Sheehan's syndrome
``` postpartum pituitary hemorrhage chiasmal compression bitemporal hemianopsia severe headache ``` failure to lactate
438
Cushings disease
adrenocorticotropic hormone pituitary gland dexamethasone suppression test
439
essential tremor
propranolol primidone benzodiazepines botox
440
glutamate receptors
AMPA kainate NMDA
441
parkinsonism
elderly | female
442
MDD recurrence
25% 6mths 30-50% 2yrs 50-75% 5yrs
443
Tarasoff I vs Tarasoff II
I - duty to warn | II - duty to protect
444
Durham Rule
not criminally responsible if act was product of mental illness or defect
445
secondary amines
desipramine protriptyline nortriptyline
446
3rd nerve palsy | oculomotor
ptosis diplopia inability to adduct eye diabetes (benign) -pupil spared internal carotid artery aneurynm (potentially fatal) -dilated pupil
447
dementia pugilistica
post traumatic dementia apo E4 chromosome 19
448
OCD
``` clomipramine fluoxetine fluvoxamine paroxetine sertraline ``` med+CBT
449
systematic desensitization
involves relaxation techniques
450
therapeutic graded exposure
carried out in real situation
451
reattribution
CBT pt is encouraged to consider possible alternate causes for events
452
least sedating TCAs
desipramine protriptyline (myoclonic twitches)
453
ECT risk factors
no absolute contraindications ``` brain tumors aneurysms recent MI increased ICP uncontrolled HTN ```
454
carbamazepine no combos
OCPs MAOIs clozapine (bone marrow suppression)
455
enuresis
bell pad imipramine desmopressin
456
transient global amnesia
- reversible anterograde and retrograde amnesia - inability to learn new info - retain personal info/identity ask same question repeatedly men 50s or older acute several hours
457
lyme disease
borrelia burgdorferi ixodes dammini ixodes pacificus mimics neuro conditions - meningitis - Bell's palsy - Guillain-Barre rash
458
epidural hematoma
middle meningeal artery temporal or parietal areas LOC then lucid younger
459
subdural hematoma
meningeal bridging veins crescent shape older alcoholics
460
bacterial meningitis CSF
marked lymphocytosis increased protein decreased glucose
461
aseptic/viral meningitis CSF
mild-mod lymphocytosis normal-mild inc protein normal glucose
462
arsenic poisoning
mees lines -white lines in finger nails N/V/D hypotension tachycardia tx: chelation
463
ANOVA
compares two groups and determines if the differences are due to experimental influence or chance multiple binary predictor variables one continuous outcome variable
464
regression analysis
uses data to predict the value of one variable in relation to another two continuous or binary variables one continuous outcome variable
465
bereavement vs depression
depression ``` suicidality worthlessness anger/ambivalence toward deceased social contacts don't help person isolates others find depressed person irritating/annoying ``` bereavement pt evokes sympathy from others
466
methadone
inc QTc
467
PKU
autosomal recessive chromosome 12 phenylalanine hydroxyls deficiency ``` mousy odor microcephaly infantile spasms light hair/skin MR ```
468
nigrostriatrial tract
parkinsonian sxs EPS sxs substantia nigra to basal ganglia
469
mesocortical tract
negative sxs ventral tegmental area to frontal cortex
470
mesolimbic tract
positive sxs ventral tegmental area to nucleus accumbent
471
correlation coefficient
measurement of direction and strength of relationship between 2 variables
472
dopamine synthesis
tyrosine hydroxylase -rate limiting step dopamine - NE - epinephrine
473
Ganser syndrome
malingering prison giving approximate answers believes sxs are real
474
Todd's paralysis
brief postictal paralysis 48hrs contralateral to sz focus
475
hepatic encephalopathy
triphasic waves - EEG | asterixis
476
clonidine
alpha 2 agonist | decreases NE released
477
Kluver-Bucy syndrome
amygdaloid bodies hyper sexuality hyperoralitu placidity
478
impulse control disorder
comorbid - fire setting - substance use - eating disorders tx: - mood stabilizers - SSRIs - TCAs
479
catalepsy
immobile position constantly maintained (catatonia)
480
stereotypy
repetitive fixed pattern of movement or speech
481
relative risk
ration of incidence in those with risk factors to the incidence in those without risk factors
482
attributable risk
absolute incidence in pts exposed to condition that can be attributed to exposure
483
geriatric sleep
``` lower % stage 3 sleep decreased delta waves more stage 1/2 sleep less total REM sleep more REM episodes shorter REM episodes increased awakenings ```
484
lithium + clozapine
increases NMS
485
alogia
poverty of speech and thought content
486
Bowlby
separation from mother protest despair detachment/denial of affection
487
Freud stage issues
oral - dependency anal - obsessive compulsive phallic - poor resolution of Oedipal complex
488
specific phobia
``` animal natural enviornment blood injection injury situational other ```
489
most common brain tumor over 60
glioblastoma multiforme
490
AIDS
most common CNS cancer - lymphoma - -Epstein Barr most frequent CNS opportunistic infection -toxoplasmosis most common spinal cord pathology -vacuolar myelopathy
491
purging
hypokalemia hyperchloremia pancreatic inflammation esophageal erosion
492
kuru
prion disease | endemic to cannibalistic Fore people
493
Bells palsy
herpes simplex virus facial nerve palsy steroids acyclovir
494
spinal cord mets
breast lung prostate
495
vitamin b12
cobalamin
496
YMRS
Young Mania Rating Scale
497
multiple sclerosis types
relapsing-remitting -sxs clear, then return primary-progressive -sxs do not clear, new ones appear secondary-progressive -initial relapsing-remitting course, then new sxs
498
botulism
``` dysphagia dysarthria ptosis diplopia urinary retention ``` ``` infants/honey weak cry lethargy floppiness poor suck constipation ```
499
Hoovers sign
pt does not give effort in unaffected leg when asked to push down with affected leg (feigning)
500
SIADH
carbamazepine SSRI decreased urine output
501
NE reuptake inhibitor
TCAS venlafaxine bupropion nefazodone
502
pellagra
niacin deficiency vitamin b3 dementia dermatitis diarrhea
503
pimozide
tics - Tourettes dopamine antagonist
504
brief psychiatric rating scale
psychosis | schizophrenia
505
thioridazine
``` Mellaril retrograde ejaculation low EPS anticholinergic orthostatic hypotension ```
506
sarcoidosis
granulomatous disease multiple organs peripheral neuropathy facial nerve palsy
507
OCPD
``` isolation of affect undoing reaction formation intellectualization rationalization ```
508
antihypertensives inc depression
propranolol | alpha-methyldopa
509
Lewy body dementia psychosis
no antipsychotics cholinesterase inhibitor lower dose of antiparkinson med
510
GAD
at least 3 somatic sxs - restlessness - fatigue - difficulty concentrating - irritability - muscle tension - sleep disturbance excessive worry multiple events 6mths
511
exposure and response therapy
OCD | specific phobia
512
motivational enhancement therapy
substance use
513
serotonin syndrome vs NMS
NMS - muscle rigidity - high CPK serotonin syndrome - clonus - GI sx - hyperreflexia
514
Lewy body dementia
visual hallucinations fluctuating cognition Parkinsonism REM sleep behavior do neuroleptic sensitivity low uptake in basal ganglia
515
fiduciary duty
obligation to work in pts best interest
516
beneficence
help pts and relieve suffering
517
chronic alcoholism
cerebellar atrophy truncal ataxia (vermis) gait unsteadiness wide-based gait
518
T test
one binary predictor variable | one continuous outcome variable
519
chi squared test
one binary predictor variable | one binary outcome variable
520
binary variable
two possible values yes/no positive/negative female/male
521
continuous variable
falls somewhere on a range height weight age
522
correlation
one continuous predictor variable | one continuous outcome variable
523
homocystinuria
``` pectus excavatum ocular lens dislocation Marfan's habitus mental retardation scoliosis ``` error of amino acid metabolism
524
most common single-gene cause of autism
fragile x
525
neurotic defenses
displacement | repression
526
immature defenses
hypochondriasis | introjection
527
sensory deficits
thalamic lesions/strokes | posterior cerebral arteries
528
HIV related dementia
``` difficulty w/attention and concentration bradyphrenia (slowed thought) social withdrawal apathy depression fatigue ``` gait incoordination rigidity slowness of gait fine and skilled hand and finger movements affected
529
Parkinsons dementia
- depigmentation and neuronal loss of substantial nigra - presence of Lewy bodies - dopaminergic under activity in the striatum - 60-85% of stratal dopamine neurons must be lost before sxs - asymmetrical early in disease - bilateral later in course - levodopa-carbidopa mainstay tx - dopamine agonists - MAOIs - anticholinergics
530
low folate
``` fatigue agitation depression delirium dementia psychosis paranoia ```
531
PTSD risk factors
heavy alcohol use women childhood trauma perception of an external locus of control (natural cause) (not human cause) borderline personality do paranoid dependent antisocial very old very young
532
erythromycin
increase carbamazepine levels
533
postherpetic neuralgia
deep, burning pain worsened by light touch follows herpes zoster (shingles) gabapentin
534
hemicrainia continua
women continuous headache indomethacin
535
prion diseases
Creutzfeld-Jakob disease kuru (New Guinea) Gerstmann-Straeussler-Scheinker syndrome fatal familial insomnia
536
episodic memory
declarative memory recall of personal facts what you ate for dinner what you did on vacation
537
semantic memory
declarative memory recall of general facts who was 1st president difference between bus/train
538
procedural memory
how to drive | how to type
539
declarative memory
retention and recall of facts semantic episodic
540
anxiety disorders
women higher than men OCD equal
541
tardive dystonia
slow sustained twisting movement of the limbs, trunk, neck | tardive dyskinesia - choreoathetoid movement, involuntary, irregular
542
face validity
dx based on general consensus among clinicians and researchers
543
descriptive validity
dx based on characteristic features that distinguish it from other disorders
544
predictive validity
dx will allow clinicians to accurately predict tx response and clinical course
545
construct validity
dx based on understanding of underlying pathophysiology
546
black box suicide warning
SSRIs SNRIs atomoxetine
547
PANSS
positive and negative sx scale psychosis
548
CAPS
PTSD
549
postpartum depression
onset within 4wks
550
palilalia
repetition of one's own speech
551
biofeedback
anxiety
552
Guillain-Barre vs transverse myelitis
GB -lower motor neuron signs TM - upper motor neuron signs - loss of bowel/bladder control
553
bipolar maintenance
lamotrigene
554
bipolar mania
valproic acid | carbamazepine
555
pregnancy categories
A- studies show no human risk B- animal studies show no risk C- animal studies show risk D- human fetal risk seen (may use in life-threatening situations) E- proved fetal risk (no indication even in life-threatening situations)
556
most common anxiety disorder
specific phobia also most common mental disorder among women 2nd most common in men (after substance use)
557
culture
correlates with ethnicity set of meanings, norms, beliefs, values, behavior patterns shared by a group of people taught, passed on way of life/customs
558
race
people grouped based on outer appearance biologic and genetic underpinnings
559
ethnicity
subjective sense of belonging to a group of people with a common national or regional origin shared believes, value and practices, including religion common heritage, ancestry, history
560
lithium metabolism
reabsorbed in proximal tubules w/Na ``` decrease Na (low Na diet, HCTZ) increase reabsorption ```
561
ipecac
heart probs tachycardia inc LFTs skeletal muscle atrophy
562
left brain
logical, analytical
563
right brain
creative, emotional, intuitive
564
Eri Erikson
epigenetic principle each stage must be properly resolved for development to proceed normally
565
differences in myositis
inclusion body myositis - men - worse on one side - most common polymyositis - women - symmetrical - follows flu like illness dermatomyositis -women -skin involvement symmetrical
566
nicotine withdrawal
bradycardia insomnia 4 sxs w/in 24 hours - DSM
567
t-Pa
within 3 hours of sx onset - neuro deficit - no hemorrhage on CT exclusion: - improving neuro deficit - seizure - prior intracranial hemorrhage - blood glc high or low - GI or GU bleed in past 3wks - recent MI - anticoagulants - thrombocytopenia - major surgery past 3mths - stroke/head injury past 3mths - arterial puncture past 7days - BP over 185/110
568
nystagmus
PCP inhalants alcohol sedative hypnotics
569
brain death
- coma (may retain spinal reflexes) - no spontaneous respirations - absence of brain stem reflexes (pupillary, oculocephalic, corneal, gag) - EEG silence (isoelectric not mandatory) - absence of cerebral blood flow - absence of reversible causes - positive apnea test (necessity)
570
glucuronidation
``` phase II (phase I = oxidation/cyp) ``` lorazepam oxazepam temazepam
571
suicide
50% - affective dos (MDD, bipolar) 25% - substance abuse 5% - personality dos 4-10% borderlines complete 5% antisocials complete 5-10% schizophrenics complete affective dos 30x risk
572
clozapine contraindications
agranulocytosis ``` carbamazepine phenytoin propylthiouracil sulfonamides captopril ```
573
phentolamine
pheochromocytomoa cocaine hypertension MAOI hypertensive crisis
574
child abuse risk factors
``` poverty psychosocial stress less parental education underemployment poor housing single parenting welfare reliance many children physical handicap MR prematurity parental mental illness parents substance abuse social isolation domestic violence ```
575
dialectical
substitutes both/and for either/or sees truth as an evolving product of the opposition of different views seeking synthesis between seemingly contradictory ideas and emotions
576
pedophilia
perpetration at least 16 at least 5yrs difference prepubescent child (13 or younger) do not include late adolescent w/12yo or 13yo
577
encopresis
at least 4yo at least monthly x3mths more common in boys correlates with: sexual abuse maternal hostility punitive/harsh parenting
578
benzos
pregnancy category D
579
kappa
quantifies degree of agreement between two raters in a study tells whether test produces reliable/reproducible results
580
capacity
- communicate a choice - understand info presented - understand how info related to own circumstances - reason in logical manner (even if most people wouldn't agree w/decision)
581
Benton visual retention test
Rey 15?
582
anticipation
planning for future inner discomfort mature defense
583
schizoid fantansy
indulging in autistic-like retreat to resolve conflict interpersonal intimacy avoided by driving others away w/eccentricity immature defense
584
ECT indications
depression psychosis mania OCD?
585
interpretation
making something unconscious conscious links feeling, thought, behavior, symptom to its unconscious meaning
586
clarification
reformulating what pt has said to create coherent view of what has been communicated
587
flunitrazepam
Rohypnol
588
cyclothymia
hypomania depressive sxs that do not meet criteria for MDD at least 2yrs
589
agoraphobia
fear of being in places or situations that may be difficult to escape from
590
avoidance
learn to avoid certain painful stimuli by avoiding certain behaviors dont go to crowded mall lobby bc it causes panic attacks variation of negative reinforcement
591
borderline therapy
DBT mentalization therapy transference-focused psychotherapy (Kernberg)
592
PTSD criteria
1 intrusion sx (nightmares) 1 avoidance sx (restricted affect?) 2 increased arousal sxs 2 negative cognition/mood sxs
593
classical conditioning
neutral stimulus (conditioned) (chainsaw) paired with a stimulus that evokes a response (unconditioned) (fire) in time, neutral stimulus elicits same response as as unconditioned stimulus
594
operant conditioning
voluntary behavior is modified as pt actively tries different behaviors to see which will deliver desired reward
595
Premack's principle
behavior engaged in at high frequency (things we like to do) can be used to reinforce behavior that occurs at a low frequency (things we don't like to do)
596
prior to ECT
``` CBC CT (suspicion of sx or tumor) EKG CXR? dental exam in elderly spine X-ray (if spinal disease) ```
597
ECT anesthesia
most common: methohexital (Brevital) don't use due to inc sz threshold: propofol
598
mania in medical conditions
glioma cushings disease MS
599
drugs causing mania
``` isoniazid cimetidine metoclopramide steroids bronchodilators antidepressants anticonvulsants stimulants barbiturates drugs of abuse ```
600
facilitation
using verbal and nonverbal cues to encourage pt to keep talking
601
clarification
tries to get more details about what the pt has already said
602
poor prognosis for paraphilias
- early age of onset - lack of guilt/shame - high frequency of acts - substance use - no coitus w/paraphilic act - low IQ - personality dos - lack of attachment/relationships - axis I do - multiple paraphilias
603
paraphilia interventions
- CBT - insight-oriented psychotherapy - anti androgens - twelve step programs - sex therapy
604
transsexual
wish to have body of another sex
605
genderqueer
in between genders; both genders; neither gender
606
Ford v Wainwright
competence to be executed
607
glossolalia
unintelligible jargon that has meaning to the speaker but not the listener
608
verbigeration
meaningless and stereotyped repetition of words or phrases
609
laconic speech
reduction in quality of spontaneous speech
610
pseudologia phantastica
pt believes reality of fantasies and acts on them
611
anorexia specifiers
BMI 17 mild 16 moderate 15 severe <15 extreme
612
pavor nocturnus
nighttime panic attacks
613
jactatio capitis nocturna
head banging during sleep
614
"atypical" antipsychotics
5-HT 2A antagonism help w/negative sxs
615
new onset psychosis medical ddx
``` SLE temporal lobe epilepsy neurosyphilis Wilsons disease AIDS B12 deficiency heavy metal poisoning delirium dementia Huntingtons pellagra tumor stroke/bleed herpes encephalitis autism ```
616
violence risk
``` past violent behaviors battered, underprivileged child low education poor family supports unstable housing unemployed poor coping skills lack of resources ```
617
Alzheimer's survival
8 years
618
atypical depression
hypersomnia increased appetite weight gain (= reversed vegetative sxs) tx: MAOIs
619
chronic fatigue syndrome
CBT | graded exercise therapy
620
prior to stimulants
``` pulse BP height weight physical exam ``` EKG only if concern for cardiac issues
621
stimulant abuse
Vyvanse - prodrug, not active is snorted, crushed, injected Concerta, Metadate ER - extended release
622
delirium risk factors
``` age over 70 male alcohol abse smoking recent surgery brain damage/disease diabetes cancer blindness malnutrition intoxication/withdrawal ```
623
delirium causing meds
``` narcotic painkillers steroids anesthetics antineoplastic agents anticholinergics antibiotics antifungals antiviral agents ```
624
delirium pathophys
reticular formation (attention and arousal) dorsal tegmental pahtway mesencephalic retircular formation - tectum and thalamus
625
delirium neurotransmitters
NE (inc) serotonin acetylcholine (dec) glutamate
626
EEG
delirium - background slowing triphasic waves - hepatic encephalopathy PLEDs - herpes simplex virus encephalitis temporal lobe spikes - temporal lobe epilepsy hypsarrhythmia - infantile spasms
627
IV haldol
torsades de pointes
628
delirium aftermath
depression | PTSD
629
conversion do vs somatic sx do
conversion do - neuro sxs (motor or sensory) - la belle indifference - acute/pts recover somatic sx do - somatic/physical sxs and maladaptive thoughts - histrionic about sxs - chronic/relapsing-remitting - both involuntarily produced - both could involve pain
630
naltrexone
5 days after short acting narcotic 10 days after long acting narcotic
631
suboxone
buprenorphine/naloxone 8/4, 2/0.5 typical maintenance doses: 4-16mg qd
632
cannabis withdrawal
``` insomnia irritability restlessness depression nervousness anxiety muscle twitches sweating ```
633
MDD
5 sxs | 1 must be depressed mood or loss of interest