Body Fluid Compartments Flashcards Preview

Human Epithelial Biology > Body Fluid Compartments > Flashcards

Flashcards in Body Fluid Compartments Deck (42)
Loading flashcards...
1

What are the units of osmolarity?

osmol/l

2

What is required to calculate osmolarity?

2 factors i.e. 150mM NaCl and 100mM MgCl2

3

What is tonicity?

the effect on cell volume
isotonic - normal
hypotonic - too much water
hypertonic - too little water

4

What does hypertonicity cause?

cell shrinkage

5

What does hypotonicity cause?

cell lysis from swelling

6

What are the units of osmolality?

osmol/kg

7

What is different between osmolarity and tonicity?

tonicity takes into consideration the ability of a solute to cross the cell membrane

8

What is the Total Body Water percentage of a male and female?

male 60% of body weight
female 50% of body weight

9

What does total body water exist as?

2 major compartments of ICF and ECF

10

What is the concentration of water in ICF and ECF?

ICF 67% TBW
ECF 33% of TBW

11

What is included in EC fluid?

plasma
interstitial fluid
lymph - negligible
transcellular fluid - negligible

12

How might you trace TBW?

3H2O

13

How might you trace ECF?

Inulin

14

How might you trace plasma?

labelled albumin

15

What is TBW equivalent to?

ECF+ICF

16

How do you measure the volume of distribution?

take the tracer and equilibrate it with water
take a small sample and measure the concentration
c=m/v
work out volume of distribution

17

What is the equation for calculating the volume of distribution?

V (L)=Dose/Sample concentration

18

What is insensible loss of water?

loss through skin and lungs

19

What is sensible loss of water?

faeces
urine
sweat

20

What is the general input and output of water/day?

2500ml

21

What may increase water loss through sweat?

hot weather and exercise

22

What may increase water loss through the lungs?

exercise

23

What decreases the water loss from urine?

hot weather and exercise

24

What is the general ICF and ECF concentrations of Na?

ICF - 10
ECF -140

25

What is the general ICF and ECF concentrations of K?

ICF - 140
ECF - 4.5

26

What is the general ICF and ECF concentrations of Cl?

ICF - 7
ECF - 115

27

What is the general ICF and ECF concentrations of HCO3?

ICF -10
ECF -28

28

What is particularly potent in the plasma?

Na, Cl, HCO3, protein anions

29

What is particularly potent in the interstitial fluid?

Na, HCO3, Cl

30

What is particularly potent in the IC fluid?

K, PO4, Mg, protein anions, small Na