Body Fluid Compartments Flashcards Preview

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Flashcards in Body Fluid Compartments Deck (26)
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1

What percent of total body weight is solids?

40%

2

What percent of body weight (BW) equals total body water (TBW)?

60%

3

What percent of BW = intracellular fluid (ICF)?

40%

4

What percent of BW = extracellular fluid (ECF)?

20%

5

What percent of ECF = interstitial fluid (ISF)

75%

6

What percent of ECF = plasma?
What percent of plasma = venous?
What percent of plasma = effective circulating volume?

25%

80%

20%

7

Probably just a good idea to draw the picture on the test.

DRAW THE DANG PICTURE

8

What is volume of distribution of a drug?

What is it used for?

Reflection of how a drug will distribute in the body.
The volume of plasma that would be necessary to account for the total amount of drug in the patient's body, if found in the same concentration as the plasma.
Used in calculating loading doses and TBW.

9

What are the 4 levels of Vd (volume of distribution)?

<3 L = Drug only in plasma
14 L = Drug in plasma and ECF (interstitial fluid)
40-45 L = Drug in TBW
> 45 L = Drug widely distributed in TBW and tissues (i.e. bone)

10

Name two systems that bring water/nutrients into the body?

GI and carbohydrate metabolism.

11

Name 5 systems do output of water?

Kidneys, lungs, feces, sweat, skin

12

Major XC cations and anions.

Na+ and Cl-

13

Major IC cations and anions.

K+ and PO4- (and organic anions)

14

What is the pressure generated by large molecules (like proteins) in solution that are impermeable to membranes?

Oncotic (colloid osmotic) pressure

15

What do you use to find these values experimentally?
TBW?
ECF?
ICF?
Plasma Volume?
Interstitial fluid?

Utilize the indicator that remains within the compartment you want to evaluate.
TBW: radioactive H2O, antipyrine
ECF: radioactive Na, inulin
ICF: TBW - ECF = ICF
Plasma volume: albumin, evans blue dye (binds albumin)
Interstitial fluid: ECF - Plasma = ISF

16

What is the gibbs-donnan effect?

What is the normal Na+ and K+ osmolality?

The negative charge of proteins within the vasculature brings the Na+ and K+ slightly higher than expected.
290 mOsm

17

Finish the sentence. Where Na+ goes ...

Water follows

18

How do you quickly estimate plasma osmolality?

2[Na+]

19

What's the full plasma osmolality equation?
When is this unreliable?

2]Na+] + (glucose/18) + (urea/2.8)

In diabetes or kidney failure (too much glucose or urea)

20

What is highly permeable between ECF and ICF?

Water

21

Fluid distribution of the ECF compartments is due to what?

Starling forces

22

What is the force that favors filtration?
Opposes filtration?

Capillary hydrostatic pressure

Colloid osmotic (oncotic) pressure

23

What is the equation for capillary filtration? (Starling forces)

Capillary filtration = K(f) * (Pc-Pif) - (pi(c) - pi(if))

24

All solutes and water that enter or leave the body do so via?

The ECF

25

What happens to the following variables when water loss (dehydration) occurs?
ECF?
ICF?
ECF mOsm?
ICF mOsm?

ECF = Decrease

ICF = Decrease

ECF mOsm = Increase

ICF mOsm = Increase

26

What is the difference between crystalloid and colloid fluids? What are they used for?

Water therapy.

Crystalloid = electrolytes and stay in the ECF (saline)
Colloid = proteins and large molecules that stay in vascular space (dextran, albumin)