Bologna CH111 Adnexal Neoplasms

Question 1

Hair follicle naevi are hamartomas in which hairs and follicles that ensheath them have abnormal morphology or size or are present in increased numbers

Answer 1

T

Question 2

Hamartomas are benign proliferation’s composed of cellular elements native to a site, in aberrant proportion

Answer 2

T

Question 3

Accessory tragus overlaps with hair follicle naevus (two entities may be the same)

Answer 3

T

Question 4

Child grows proportionally with hair follicle naevus

Answer 4

F , child grows disproportionally faster than the lesion

Question 5

Trichofolliculoma presents as a papule or nodule involving the face, scalp or upper trunk

Answer 5

T

Question 6

How does Pilar sheath acanthoma differ from trichofolliculoma?

Answer 6

Pilar sheath acanthoma similarly has a central infundibulum with follicle structures radiating from the centre, however they do not recapitulate the full hair follicle - only follicular isthmus and outer sheath (unlike trichofolliculoma)_

Question 7

Disorders with angiofibromas

Answer 7

TS
Birt-Hogg-Dube
MEN1

Question 8

Fibrofolliculoma displays slender strands of follicular mantle cells emanating from a folliculosebaceous unit at the level of the isthmus

Answer 8

T

Question 9

Naevus sebaceous - list secondary neoplasms

Answer 9

TTDSAP 
Trichoblastoma (most common)
Trichilemmoma
Desmoplastic trichoepithelioma
Sebaceous adenoma
Apocrine adenoma
Poroma 

• malignancy probably develops only in longstanding or neglected lesions but exceptionally can be a source of mortality

Question 10

Pathology of chondroid syringoma

Answer 10

• prominent collagen component to stroma, but myxoid and lipocytic zones can also be found
  —> large inter-anastomosing and branching tubules lined by two cell layers - columnar cells with decapitation secretion at the luminal border and cuboidal cells peripherally (this configuration has been dubbed apocrine mixed tumour)

Question 11

Disorders with pilomatricoma

Answer 11

Rubenstein turns wool in my garden

• Rubenstein syndrome
• Turner Syndrome
• edWard syndrome
• Myotonic dystrophy
• Gardner’s syndrome

Question 12

Retention of PTEN expression with trichilemmoma , assessed with IHC, is suggestive of Cowden syndrome

Answer 12

F, loss of PTEN expression

Question 13

There is increased incidence of syringomas in Asian population

Answer 13

T

Question 14

Poromas can occur following chemotherapy or radiation therapy

Answer 14

T

Question 15

Palms and soles demonstrating sessile vascular plaques with a thin indented moat is suggestive of which tumour

Answer 15

Poromas

Question 16

Microcystic adnexal carcinoma typically presents in the elderly

Answer 16

F, in young or middle aged adults

Question 17

MAC presents more commonly in males

Answer 17

F , in women and occasionally children