Bone drugs Flashcards Preview

Pharmacology II - Exam 3 > Bone drugs > Flashcards

Flashcards in Bone drugs Deck (20)
Loading flashcards...
1
Q

what 3 factors regulate calcium homeostasis

A

vit d, PTH, and FGFP 23

2
Q

what is the net effect of vit d (calcitriol) on plasma ca and po4

A

increases both

3
Q

what is the net effect of PTH on plasma ca and po4

A

increases plasma ca and decreases plasma po4

4
Q

what is the net effect of FGF23 on plasma ca and po4

A

no effect on plasma ca and decreases plasma po4

5
Q

what disregulated ion causes cardiac arrythmias and seizures?

A

ca (HYPOcalcemia)

6
Q

when calcium levels are low, what happens to vit d and PTH?

A

both increase

7
Q

if calcium levels are increased, what happens to PTH and vit d

A

both decrease

8
Q

if PO4 levels increase, what happens to FGF23, PTH, and vit d?

A

FGF23 and PTH increase and vit d decreases

9
Q

deficiency of what will cause hypocalcemia

A

PTH

10
Q

How does estrogen impact osteoblast and osteoclast activity

A

Increases osteoblasts and decreases osteoclasts

11
Q

How does menopause affect bone loss

A

rapid degeneration of trabecular bone in 3-5 years (results in vertebral fractures) slow degeneration of cortical bone in 10 to 20 years

12
Q

how much calcium should you recommend your patients take

A

800-1000 mg

13
Q

how much vit d should your patients take

A

800 IU

14
Q

what are the adverse effects of calcium supplementation

A

gi upset, urolithiasis, prostate cancer, constipation

15
Q

moa of ca

A

increase GI uptake of ca, decrease PTH release, and increase remodeling

16
Q

moa of vit d supplementation

A

increase GI absorption of calcium and phos and decrease PTH

17
Q

moa of bisphosphonates

A

decrease # of osteoclasts, decreases bone resorption and decreases apoptosis

18
Q

what are the names of the first line bisphosphonates

A

alendronate, risedronate, and zoledronate

19
Q

how should bisphosphonates be taken to increase absorption

A

sitting up, with water, 1 hour prior to any other oral intake that day

20
Q

adverse effects of bisphosphonates

A

jaw osteonecrosis, arthralgias, myalgias, atypical femur fracture, esophageal ulcer