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Pharmacology II - Exam 3 > Bone drugs > Flashcards

Flashcards in Bone drugs Deck (20):
1

what 3 factors regulate calcium homeostasis

vit d, PTH, and FGFP 23

2

what is the net effect of vit d (calcitriol) on plasma ca and po4

increases both

3

what is the net effect of PTH on plasma ca and po4

increases plasma ca and decreases plasma po4

4

what is the net effect of FGF23 on plasma ca and po4

no effect on plasma ca and decreases plasma po4

5

what disregulated ion causes cardiac arrythmias and seizures?

ca (HYPOcalcemia)

6

when calcium levels are low, what happens to vit d and PTH?

both increase

7

if calcium levels are increased, what happens to PTH and vit d

both decrease

8

if PO4 levels increase, what happens to FGF23, PTH, and vit d?

FGF23 and PTH increase and vit d decreases

9

deficiency of what will cause hypocalcemia

PTH

10

How does estrogen impact osteoblast and osteoclast activity

Increases osteoblasts and decreases osteoclasts

11

How does menopause affect bone loss

rapid degeneration of trabecular bone in 3-5 years (results in vertebral fractures) slow degeneration of cortical bone in 10 to 20 years

12

how much calcium should you recommend your patients take

800-1000 mg

13

how much vit d should your patients take

800 IU

14

what are the adverse effects of calcium supplementation

gi upset, urolithiasis, prostate cancer, constipation

15

moa of ca

increase GI uptake of ca, decrease PTH release, and increase remodeling

16

moa of vit d supplementation

increase GI absorption of calcium and phos and decrease PTH

17

moa of bisphosphonates

decrease # of osteoclasts, decreases bone resorption and decreases apoptosis

18

what are the names of the first line bisphosphonates

alendronate, risedronate, and zoledronate

19

how should bisphosphonates be taken to increase absorption

sitting up, with water, 1 hour prior to any other oral intake that day

20

adverse effects of bisphosphonates

jaw osteonecrosis, arthralgias, myalgias, atypical femur fracture, esophageal ulcer