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Flashcards in bone neoplasms/tumors Deck (57)
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A __________ is an uncommon neoplasm that probably arises from periodontal ligament fibroblasts

Central Ossifying Fibroma


Central Ossifying Fibromas can often be confused with what benign condition?

focal cemento-osseous dysplasia


Clinical characteristics of Central Ossifying Fibromas:

1) Mandibular premolar/molar region

2) often in adult female, 3rd to 4th decade

3) Asymptomatic swelling, root divergence, facial deformity with larger lesions


Radiographic features of Central Ossifying Fibromas:

A) Well-circumscribed radiolucency with variable amount of central opacity

B) Range from almost purely radiolucency to very radiodense with a well-defined lucent border


T/F: when surgically removing a central ossifying fibroma, the lesional tissue will separate readily from the underlying bone



Histological characteristics of Central Ossifying Fibromas:

A) Cellular fibrous connective tissue with calcified trabeculae/spherules resembling cellular cementum or woven bone

B) Similar histology to fibrous dysplasia/COD, radiographic correlation is often helpful


what is the treatment/prognosis/reoccurrence for central ossifying fibromas?

1) Treatment consists of enucleation

2) Prognosis is very good

3) recurrence rate of 12%


what is an Osteoma? what bones does it usually effect?

Benign osseous tumor

primarily affecting craniofacial bones (esp. paranasal sinuses)


Characteristics of Osteomas:

1) Painless, slowly enlarging

2) In the jaws, predilection for mandibular body and condylar area

3) Histology: normal bone +/- marrow tissue


T/F: Gardners syndrome has an Autosomal Recessive inheritance pattern


Autosomal Dominant


Inheritance characteristics of Gardners Syndrome:

A) 1:8,000-16,000 live births

B) One of the familial adenomatous polyposis syndromes

C) APC gene, chromosome 5


what are the clinical characteristics of Gardners syndrome?

1) Characterized by multiple osteomas of the facial bones (skull, paranasal sinuses, mandible)

2) epidermoid cysts and desmoid tumors


Radiographic features of Gardners Syndrome:

A) osteomas of Gardner syndrome can resemble florid cemento-osseous dysplasia or osteitis deformans

B) May see impacted supernumerary teeth or, less commonly, odontomas


The most significant aspect of Gardners syndrome is the development of __________________

precancerous polyps of the colon


50% of patients with gardeners syndrome develop _____________ of the colon by 30 years of age



how is gardeners syndrome managed?

A) Prophylactic colectomy

B) Removal of problematic cysts and osteomas

C) Removal of impacted teeth/odontomas with prosthodontic work as needed

D) Genetic counseling


what neoplasm is considered "controversial" due to the fact it may be either a neoplasm or simply a reactive process?

Central Giant Cell Granuloma


clinical characteristics of Central Giant Cell Granulomas:

1) Broad age range, 60% of pts are under 30 yrs old

2) 2:1 female predilection

3) location: Mandible favored (70%), often anterior, frequently crossing the midline


Small central giant cell granulomas are often ________, while larger lesions become ________ and _________

Unilocular when small; larger lesions become multilocular and expansile


what are the histopathological characteristics of giant cell granulomas?

A) cellular granulation tissue with numerous benign multinucleated giant cells

B) RBC extravasation and hemosiderin deposits are common


what is the treatment/prognosis/recurrence rate for Giant Cell Granulomas?

A) Treatment generally consists of aggressive curettage, although alternative non-surgical therapies have been reported

B) Recurrence rate of approximately 20%

C) Prognosis is generally considered good


____________ is caused by the Inappropriate secretion of parathormone



Define primary and secondary Hyperparathyroidism:

Primary - due to parathyroid hyperplasia, parathyroid adenoma, parathyroid carcinoma

Secondary - due to renal failure, which is responsible for poor calcium retention and altered vitamin D metabolism


what are the radiographic characteristics of Hyperparathyroidism lesions?

1) Radiographically, loss of lamina dura and “ground-glass” trabecular pattern

2) Unilocular/multilocular radiolucencies may develop - “brown tumor”


T/F: diffuse jaw enlargement can be caused by chronic renal failure


secondary hyperparathyroidism (jaw enlargement) caused by renal failure


what are the histopathological characteristics of lesions caused by Hyperparathyroidism?

1) Microscopically identical to central giant cell granuloma

2) brown tumors show vascular granulation tissue with numerous multinucleated giant cells and extravasated erythrocytes


what is the definition of Renal Osteodystrophy?

Hyperplastic response of the bone in patients with poorly-controlled secondary hyperparathyroidism related to end-stage renal disease


what physical effects can result from Renal Osteodystrophy?

Prominent jaw enlargement may result


what are the treatments for hyperparathyroidism?

If primary, remove the source of excess hormone secretion

If secondary, better control of serum calcium levels. Parathyroidectomy may be needed if medical therapy fails. Renal transplant is another alternative


A ___________ is a malignancy showing production of osteoid by tumor cells