Bone Structure / Function Flashcards Preview

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Flashcards in Bone Structure / Function Deck (11):
1

How do long / short bones form?
What protein suppresses long bone growth?

Endochondral ossificiation
FGFR3

2

How do flat bones form?

Intramembranous ossification, which involves loose condensations of mesenchymal tissue.

3

Which genes stimulate osteoblast growth?
What happens if gene is mutated?

Cbfa1 and RUNX2. If lose 1 copy, flat bones are damaged.

4

3 sources of blood supply for bones

Nutrient arteries (supply inner 2/3), periosteal membrane arteries (supply outer 1/3) and metaphyseal complex

5

Cells of origin for osteoblasts, osteoclasts, and osteocytes

Blasts / cytes come from mesenchymal cells.
Clasts come from hematopoietic lineage (similar to macrophages)

6

What is osteocalcin?

Marker for osteoblastic activity

7

Where do osteoclasts live?

Howship's lacunae

8

What does osteoprotegerin do?

Stops bone breakdown by binding to RANK ligand on osteoblasts, preventing binding of RANK on osteoclasts.

9

Which cancers favor RANKL vs OPG?

RANKL: giant cell tumor, MM, breast cancer
OPG: prostate cancer

10

Teriparatide

Recombinant PTH. Only anabolic treatment

11

Denosumab

RANKL Ab. Acts similar to OPG by preventing osteoclast activation.