Flashcards in Bone Structure / Function Deck (11):
How do long / short bones form?
What protein suppresses long bone growth?
How do flat bones form?
Intramembranous ossification, which involves loose condensations of mesenchymal tissue.
Which genes stimulate osteoblast growth?
What happens if gene is mutated?
Cbfa1 and RUNX2. If lose 1 copy, flat bones are damaged.
3 sources of blood supply for bones
Nutrient arteries (supply inner 2/3), periosteal membrane arteries (supply outer 1/3) and metaphyseal complex
Cells of origin for osteoblasts, osteoclasts, and osteocytes
Blasts / cytes come from mesenchymal cells.
Clasts come from hematopoietic lineage (similar to macrophages)
What is osteocalcin?
Marker for osteoblastic activity
Where do osteoclasts live?
What does osteoprotegerin do?
Stops bone breakdown by binding to RANK ligand on osteoblasts, preventing binding of RANK on osteoclasts.
Which cancers favor RANKL vs OPG?
RANKL: giant cell tumor, MM, breast cancer
OPG: prostate cancer
Recombinant PTH. Only anabolic treatment