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Flashcards in Bone Tumors Deck (8)
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1
Q
Osteoid Osteoma
Definition
Location
Age Range
Path/Imaging
Clinical/Notes
A
  • Benign tumor of OSTEOBLASTS (that produce osteoid) surrounded by a RIM of reactive bone
  • Diaphysis, Cortex of long bones (femur), < 2 cm
  • teens and < 25 y/o
  • diaphyseal cortical with sclerotic thickening around a small lucent (osteoid/osteoblast) tumor
  • Bone pain that resolves with ASPIRIN
2
Q
Osteosarcoma
Definition
Location
Age Range
Path/Imaging
Clinical/Notes
A
  • MALIGNANT proliferation of OSTEOBLASTS
    Distal Femur, proximal tibia: knee area, intramedullary, cortical, periosteal
  • Teens, Elderly, Bi-modal
  • Metz to LG, Imaging&raquo_space; destructive mass with ‘sunburst’ appearance and lifting of periosteum
  • Pain, fracture, swelling
  • Risk factors: retinoblastoma, Paget dz, radiation exposure
3
Q
Osteochondroma
Definition
Location
Age Range
Path/Imaging
Clinical/Notes
A
  • Cartilage-bone, Most common bone tumor
  • meta-diaphyseal
  • Teens
  • arises from lateral projection of growth plate (meta-diaphysis), bone is contiguous with marrow space
  • may progress to chondrosarcoma
4
Q
Chondroma
Definition
Location
Path/Imaging
Clinical/Notes
A
  • benign tumor of cartilage
  • medulla of SMALL BONES of HANDS AND FEET
  • lytic with speckled calcification
  • Ollier’s: multiple chondromas with fibrous dysplasia
  • Mafucci’s: multiple chondromas with angiomata
5
Q
Chondrosarcoma
Definition
Location
Age Range
Path/Imaging
Clinical/Notes
A
  • malignant tumor of cartilage
  • Medulla of PELVIS or CENTRAL SKELETON
    may also be peripheral
  • > 50 y/O
  • Histology may be low grade or high grade
  • slowly enlarging mass
6
Q
Giant Cell Tumor
Definition
Location
Age Range
Path/Imaging
Clinical/Notes
A
  • benign, but aggressive, tumor of giant cells and stromal cells
  • Metaphyseal, May extend to epiphysis Often knee
  • 20-40 y/o
  • lytic lesion appearing after closure of growth plates: “soap bubble” appearance
  • pain, fracture, high recurrence
7
Q
Ewing Tumor
Definition
Location
Age Range
Path/Imaging
Clinical/Notes
A
  • malignant proliferation of poorly-differentiated cells derived from NEUROECTODERM and mononuclear cells * diaphysis of long bones
  • 5-15 y/o
  • onion skin appearance on Xray, Biopsy: small round blue cells that look like lymphocytes, but are glycogen-rich
    11;22 translocation&raquo_space; fusion protein of EWS-FLI-1
  • may MIMIC: ALL, metz neuroblastoma, osteomyelitis
8
Q
Fibrous Tumor-Like Conditions
Location
Age Range
Patho/Imaging
Clinical
A
  • Diaphyseal, intramedullary fusiform lesions of long bones
  • usu children
  • fusiform lesions with “ground glass,” Spindle cells, collagen matrix, woven bone”
  • monostotic