Bones from MLC Flashcards
(23 cards)
most common mesenchymal bone tumor; bimodal age distribution: larger group under 20 y.o. and 2nd peak in elderly in context of Paget disease
Osteosarcoma
If you see lifting of the periosteum (aka Codman’s triangle) on xray, what is it?
osteosarcoma
adolescent man with cortical tumor of femur; painful at night or with EtOH; relieved by aspirin.
osteoid osteoma
diaphyseal tumor of childhood with characteristic “onion-skin” periosteal reaction; 75% 5 yr survival with chemo
Ewing Sarcoma
t(11:22) + small blue cell tumor + peripheral CD99 staining
Ewing Sarcoma
neoplastic stromal cells produce RANK ligand in tumor at the junction of epiphysis and metaphysis of young adults; locally aggressive, high recurrence rate, rarely metastasizes
Giant Cell tumor
painful progressively enlarging centrally located (pelvis, shoulder, ribs) intramedullary bone tumor of adults with survival correlated with grade
chondrosarcoma
painful tumor of adolescents; sheets of compact cells within “chicken wire” mineralized matrix causing spotty calcifications in lucent epiphyseal lesions around the knee
chondroblastoma
non-neoplastic expansile lesions in pts with sever hyperparathyroidism
osteitis fibrosa cystica
small round blue cell childhood bone tumor with abundant glycogen and CD99 staining
Ewing Sarcoma
Painfully progressive enlarging lytic and blastic mass distal femur lifting periosteum forming a Codman triangle; with lung mets
osteosarcoma
neuroectoderm-derived bone tumor forming Homer-Wright rossettes t(11:22)–> ETS/FLI1 fusion gene for growth promoting TF
Ewing Sarcoma
most likely bone disease to be primarily osteoblastic
prostate adenocarcinoma
clear cell carcinoma of kidney
most likely to produce solitary bone lesion
most common soft tissue mass
lipoma
most common soft tissue sarcoma; whorled storiform pattern
undifferentiated pleomorphic sarcoma
most common soft tissue sarcoma of children and young adults
rhabdomyosarcoma
most frequent neoplasms of infancy and childhood
hemangioma
cytogenic abnormalities on Chromosome 15 affect proteins involved in tissue repair like FGF-7
nodular fasciitis
list the various “small round blue cell” tumors of childhood
Ewing sarcoma lymphoma medulloblastoma neuroblastoma retinoblastoma rhabdomyosarcoma Wilms tumor
most common primary cancer of bone
multiple myeloma
McCune-Albright Syndrome
cafe-au-lait skin lesions
endocrine abnormalities (precocious puberty)
fibrous dysplasia of bone
osteomalacia
hypophosphatemia renal phosphate wasting non-traumatic fractures generalized osteopenia normal serum Ca normal PTH if not phosphate, it is Vit. D
