Book1 Flashcards

(109 cards)

1
Q

beta-oxidation

enzyme (and possible cofactors) involved in first step of beta-oxidation

A

Acyl CoA Dehydrogenase, FAD

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2
Q

beta-oxidation

enzyme (and possible cofactors) involved in second step of beta-oxidation pathway

A

Enoyl CoA Hydratase, H2O

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3
Q

beta-oxidation

enzyme (and possible cofactors) involved in third step of beta-oxidation

A

beta-OH Acyl CoA dehydrogenase, NAD

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4
Q

beta-oxidation

enzyme (and possible cofactors/substrates) involved in fourth step of beta-oxidation

A

beta-thiolase, CoASH

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5
Q

beta-oxidation

product of first reaction

A

Enoyl CoA

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6
Q

beta-oxidation

product of second reaction

A

beta-hydroxy acyl CoA

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7
Q

beta-oxidation

product of third reaction

A

ketoacyl-CoA

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8
Q

beta-oxidation

C2 product of fourth reaction

A

acetyl CoA

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9
Q

beta-oxidation

Cn –> how many acetyl CoA?

A

n/2

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10
Q

beta-oxidation

Cn –> n/2 acetyl CoA takes how many cycle turns?

A

(n/2) - 1

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11
Q

beta-oxidation

number of NADH and FADH2 produced per each cycle turn

A

1 NADH, 1 FADH2

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12
Q

beta-oxidation

number of ATP required for (n) acetyl CoA –> (2n) CO2

A

(n x 10) ATP

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13
Q

fatty acid synthesis: Activates acetyl CoA for reaction with malonyl-ACP

A

Acetyl Transferase CoASH

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14
Q

fatty acid synthesis: Activates malonyl CoA for reaction with acetyl-ACP

A

Malonyl transferase

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15
Q

fatty acid synthesis: Reacts priming acetyl-ACP with chain-extending malonyl-ACP

A

beta ketoacyl ACP synthase

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16
Q

fatty acid synthesis: Reduces the carbon 3 ketone to a hydroxyl group

A

beta ketoacyl ACP reductase

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17
Q

fatty acid synthesis: Removes water

A

beto ketoacyl ACP dehydratase

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18
Q

fatty acid synthesis: Reduces the C3-C4 double bond

A

Enoyl ACP reductase

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19
Q

enzyme:

A

Reaction: Acetyl Transferase CoASH

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20
Q

enzyme:

A

reaction: Malonyl Transferase

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21
Q

enzyme:

A

reaction: beta ketoacyl ACP synthase

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22
Q

enzyme:

A

reaction: beta ketoacyl ACP reductase

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23
Q

enzyme:

A

reaction: beto ketoacyl ACP dehydratase

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24
Q

enzyme:

A

reaction: Enoyl ACP reductase

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25
Reaction: Acetyl Transferase CoASH
enzyme: ![Acety-CoA ACP transacylase.png](http://upload.wikimedia.org/wikipedia/commons/thumb/d/dc/Acety-CoA_ACP_transacylase.png/180px-Acety-CoA_ACP_transacylase.png)
26
reaction: Malonyl Transferase
enzyme: ![Center](http://upload.wikimedia.org/wikipedia/commons/thumb/4/4d/Malonyl-CoA_ACP_transacylase.png/180px-Malonyl-CoA_ACP_transacylase.png)
27
reaction: beta ketoacyl ACP synthase
enzyme: ![3-ketoactl-ACP synthetase.png](http://upload.wikimedia.org/wikipedia/commons/thumb/f/fd/3-ketoactl-ACP_synthetase.png/180px-3-ketoactl-ACP_synthetase.png)
28
reaction: beta ketoacyl ACP reductase
enzyme: ![3-ketoacyl-ACP reductase.png](http://upload.wikimedia.org/wikipedia/commons/thumb/9/9e/3-ketoacyl-ACP_reductase.png/180px-3-ketoacyl-ACP_reductase.png)
29
reaction: beto ketoacyl ACP dehydratase
enzyme: ![3-hydroxyacyl-ACP dehydrase.png](http://upload.wikimedia.org/wikipedia/commons/thumb/f/f5/3-hydroxyacyl-ACP_dehydrase.png/180px-3-hydroxyacyl-ACP_dehydrase.png)
30
reaction: Enoyl ACP reductase
enzyme: ![Enoyl-ACP reductase.png](http://upload.wikimedia.org/wikipedia/commons/thumb/0/0d/Enoyl-ACP_reductase.png/180px-Enoyl-ACP_reductase.png)
31
Write overall equation by which palmitate is produced from acetyl CoA
8acetyl-CoA + 7ATP + 14NADPH + 14H+ ----\> CH3(CH2)14CO2- + 7ADP + 7Pi + 14NADP+ + 7H2O
32
Arachidonic acid is synthesized from:
linoleic acid
33
linoleic acid: abbreviation
C18:2 (cis 9,12)
34
C 18:2 (cis 9,12) ---(?)---\> C 18:3 (cis 6,9,12)
NADP-----\>NADPH
35
C 18:3 (cis 6,9,12) ---(?)---\> C 20:3 (cis 8,11,14)
C3 ----\> CO2
36
arachidonic acid abbreviation
C 20:4 (cis 5,8,11,14)
37
arachidonic acid structure
![File:AAnumbering.png](http://upload.wikimedia.org/wikipedia/commons/thumb/5/57/AAnumbering.png/800px-AAnumbering.png)
38
enzyme: arachidonic acid ----\> PGH2
PGH synthase/cyclooxygenase + 2O2
39
arachidonic acid ---(PGH synthase/cyclooxygenase)---\>
PGH2
40
? -----\> eicosanoid hormones
PGH2
41
PGH2 structure
![](https://www.caymanchem.com/images/catalog/17020.png)
42
mechanism by which Aspirin relieves pain
O-acetylates serine on PGH synthase (inactivating)
43
aspirin structure
![](https://encrypted-tbn2.gstatic.com/images?q=tbn:ANd9GcRfLMpd4_828HSfV_bf9G60skUiPWf-JsuBsWFkPOBQ7Lqi5TOwKA)
44
Tylenol (acetaminophen) structure
![](https://encrypted-tbn2.gstatic.com/images?q=tbn:ANd9GcSAEBZbd-RWEkUBh5ND56tyrj-jk8TCaIraXmuDnF05qeowd9Kohg)
45
Motrin (ibuprofen) structure
![](https://encrypted-tbn1.gstatic.com/images?q=tbn:ANd9GcTP5UeIGRaRAxJBLoatN7mzwNJCJI9bWZhtajtMlC2xuleIIIeNtw)
46
difference between aspirin and motril/tylonol
aspirin competes with arachidonic acid for its substrate
47
PSII: reaction center
P680
48
PSII: P680 --\>
P680\*
49
P680\* reduction potential
-400mV
50
helps P680\* --\> P680'+
PQox --\> PQred
51
PQ reduction potential
0mV
52
P680\* --\>
P680'+
53
P680'+ reduction potential
+1400mV
54
PSII electron donor
H2O
55
helps P680'+ ----\> P680
H2O --\> 1/2 O2
56
H2O reduction potential
+816mV
57
helps P680 --\> P680\*
*hv*
58
PSI: reaction center
P700
59
P700 --\>
P700\*
60
P700\* reduction potential
-1200mV
61
helps P700\* --\> P700'+
NADP --\> NADPH
62
NADP reduction potential
-320mV
63
P700\* --\>
P700'+
64
P700'+ reduction potential
+450mV
65
helps P700'+ -----\> P700
PCred --\> PCox
66
P700'+ --\>
P700
67
PC reduction potential
-320mV
68
catalyzed by rubisco
6 CO2 + 6 RuBP ----\> 12 3-PG
69
3-PG Kinase catalyzes
12 3-PG + 12 ATP ----\> 12 1,3-BPG
70
GAPDH catalyzes
12 1,3-BPG + 12 NADPH ----\> 12 GAP + 12 Pi + 12 NADP
71
Triose P Isomerase catalyzes
5 GAP ----\> 5 DHAP
72
FBP aldolase catalyzes
3 GAP + 3 DHAP ----\> 3 FBP
73
FBPase catalyzes
3 FBP ----\> 3 F6P + 3 Pi
74
Phosphoglucoisomerase catalyzes
F6P ----\> G6P
75
G6Pase catalyzes
G6P ----\> glucose
76
6 CO2 + 6 RuBP ----\> 12 3-PG
catalyzed by rubisco
77
12 3-PG + 12 ATP ----\> 12 1,3-BPG
3-PG Kinase catalyzes
78
12 1,3-BPG + 12 NADPH ----\> 12 GAP + 12 Pi + 12 NADP
GAPDH catalyzes
79
5 GAP ----\> 5 DHAP
Triose P Isomerase catalyzes
80
3 GAP + 3 DHAP ----\> 3 FBP
FBP aldolase catalyzes
81
3 FBP ----\> 3 F6P + 3 Pi
FBPase catalyzes
82
F6P ----\> G6P
Phosphoglucoisomerase catalyzes
83
G6P ----\> glucose
G6Pase catalyzes
84
2 GAP + 2 F6P ----\> 2 X-5-P + 2 E-4-P
enzyme 9
85
2 E-4-P + 2 DHAP ----\> 2 SBP
enzyme 10
86
2 SBP ----\> 2 S-7-P
SBPase
87
2 S-7-P + 2 GAP ----\> 2 X-5-P + 2 R-5-P
enzyme 12
88
2 X-5-P ----\> 2 RuMP
enzyme 13
89
2 R-5-P ----\> 2 RuMP
enzyme 14
90
6 RuMP ----\> 6 RuBP
RuMP kinase catalyzes
91
RuMP kinase catalyzes
6 RuMP ----\> 6 RuBP
92
full name: ![File:RuBP-2D-skeletal.png](http://upload.wikimedia.org/wikipedia/commons/thumb/9/93/RuBP-2D-skeletal.png/800px-RuBP-2D-skeletal.png)
structure: Ribulose-1,5-BP
93
structure: Ribulose-1,5-BP
full name: ![File:RuBP-2D-skeletal.png](http://upload.wikimedia.org/wikipedia/commons/thumb/9/93/RuBP-2D-skeletal.png/800px-RuBP-2D-skeletal.png)
94
1st enzyme in pyruvate dehydrogenase complex
pyruvate dehydrogenase
95
2nd enzyme in pyruvate dehydrogenase complex
dihydrolipoyl transacetylase
96
3rd enzyme in pyruvate dehydrogenase complex
dihydrolipoyl dehydrogenase
97
cofactor for pyruvate dehydrogenase
TPP
98
cofactor for dihydrolipoyl transacetylase
lipoic acid
99
cofactor for dihydrolipoyl dehydrogenase
FAD
100
subunits of pyruvate dehydrogenase
(Þß)24
101
subunits of dihydrolipoyl transacetylase
alpha24
102
subunits of dihydrolipoyl dehydrogenase
alpha12
103
five vitamins part of PDH complex
B1 - thiamine pyrophosphate B2 - riboflavin (FAD) B3 - nicotanimide (NAD) B5 - pantothenic acid (CoASH) Lipoic Acid
104
TPP ---\>
![](http://classconnection.s3.amazonaws.com/519/flashcards/2297519/png/untitled1354154979189.png)
105
Acetyl Lipoic Acid ---\>
![](http://classconnection.s3.amazonaws.com/519/flashcards/2297519/png/untitled1354154979189.png)
106
Acetyl Lipoic Acid structure
![](http://classconnection.s3.amazonaws.com/519/flashcards/2297519/png/untitled1354154979189.png)
107
PDH: CoASH catalyzes this reaction
![](http://classconnection.s3.amazonaws.com/519/flashcards/2297519/png/untitled1354154979189.png)
108
final product of PDH complex
succinyl CoA
109
PDH: Dihydrolipoyl dehydrogenase interacts with
FAD