BPH

Question 1

What’s the brand name of Doxazosin?

Answer 1

Cardura

Question 2

What’s the brand name of Terazosin?

Answer 2

Hytrin

Question 3

What’s the brand name of Alfuzosin?

Answer 3

Uroxatral

Question 4

What’s the brand name of Silodosin?

Answer 4

Rapaflo

Question 5

What’s the brand name of Tamsulosin?

Answer 5

Flomax

Question 6

Name all the non selective α1-Blockers?

Answer 6

Doxazosin (Cardura)

Terazosin (Hytrin)

Question 7

Name the Uroselective α1-Blockers?

Answer 7

Alfuzosin (Uroxatral)
Silodosin(Rapaflo)
Tamsulosin(Flomax)

Question 8

What are the indication of non-selective α1-blockers?

Answer 8

BPH and HTN

Question 9

What are the indications of Uroselective α1-blockers?

Answer 9

BPH

Question 10

What time of day should non selective α1-blockers be taken? Why?

Answer 10

non selective α1 -blockers should be taken at night (HS) to prevent Orthostatic hypotension (happens when you stand up and sit down.

Question 11

Common SE of non selective α1-blockers?

Answer 11

Dizziness,fatigue, Orthostatic hypotension

Question 12

Drug interaction for non selective α1-blockers?

Answer 12

Additive decrease in BP effect with anti-HTN

Question 13

Which α1-blockers are contraindicated for Hepatic deficiency?

Answer 13

Alfuzosin(Uroxatral) (CI-Mod/severe)

Silodosin(Rapaflo) - CI (Severe)

Question 14

Which α1-blockers has a common SE of Retrograde Ejaculation? And Highest incidence of Abnormal ejaculation?

Answer 14

Silodosin(Rapaflo

Question 15

Which α1-blocker should you avoid in patients with Severe sulfonamide allergy?

Answer 15

Tamsulosin (Flomax)

Question 16

Which α1-blocker prolongs QT interval?

Answer 16

Alfuzosin (Uroxatral)

Question 17

Which α1-blockers are contraindicated for Potent CYP3A4 inhibitors?

Answer 17

Alfuzosin(Uroxatral)
Silodosin (Rapaflo)
Tamsulosin (Flomax)

Question 18

Which α1-blockers have SE of abnormal ejaculation?

Answer 18

Tamsulosin (Flomax)

Silodosin (Rapaflo)

Question 19

This α1-blocker should be used in caution when

Crcl< 30ml/min?

Answer 19

Alfuzosin (Uroxatral)

Question 20

This α1-blocker dose should be changed to 4mg when
Crcl 30-50 ml/min?

What CrCl should this drug be Discontinued?

Answer 20

Silodosin (Rapaflo)

DC and Contraindicated <30ml/min

Question 21

Which α1-blockers should the dose be tirated to max dose?

Answer 21

Doxazosin (Cadura)

Terazosin (Hytrin)

Question 22

What α1-blocker has an XL formulation?

Answer 22

Doxazosin (Cardura)

Question 23

Why does the FDA warn in used in combination of alpha-antagonist and Phosphodiesterase?

Answer 23

Risk of Hypotension

Question 24

Most common surgical options for BPH?

What are risk and benefits?

Answer 24

1. Transurethral resection of the prostate (TURP), cut out piece of prostate.
2. Open Prostatectomy - Enlarged prostate removed entierely -most potential for relief but must complications

Question 25

Does α1-blocker (Alpha 1-adrenergic blockers) decrease the PSA levels?

Answer 25

No! No effect on PSA levels or Prostate size

Question 26

Does 5 α-reductase inhibitors decrease the PSA levels?

Answer 26

Yes. Reduce prostate size by 25% and decrease PSA levels by 50%?

Question 27

Which Pregancy Category is Does 5 α-reductase inhibitors?

Answer 27

Category X. Stay away from Pregnant women.

Question 28

What are the hepatic cautions of 5 α-reductase inhibitors?

Answer 28

No specific renal/hepatic dosage adjustment

Question 29

When do 5 α-reductase inhibitors work?

Answer 29

Slow onset of action: 6-12 months

Question 30

What's the brand name Dutasteride?

Answer 30

Avodart

Question 31

What's the brand name Finasteride?

Answer 31

Proscar

Question 32

Name all 5 α-reductase inhibitors?

Answer 32

Dutasteride (Avodart) | Finasteride (Proscar)

Question 33

What FDA statement was based on the PCPT and REDUCE trails?

Answer 33

Increased risk of high-grade prostate cancer with Name all 5 α-reductase inhibitors. The risk is low, but providers should be aware the overall reduction of prostate was found but increase incidence of high grade cancer was found in both trials.

Question 34

Which Phophodiesterase inhibitor can be use for BPH?

Answer 34

Tadalafil (Cialis)

Question 35

What's the brand name of Tadalafi?

Answer 35

Cialis

Question 36

What is the benefits of Tadalfil (Cialis)?

Answer 36

Reduction in total IPSS scores (international prostate symptoms score)

Question 37

What medications should be avoided with BPH?

Answer 37

1. Testosterone replacement regimen - Testostorone increase DHT which increase Prostate growth -> increase BPH 2. α-adrenergic agonist - Allergy med,Psudefed, Increase BPH 3. Anticholinergic agent- Cause Urinary retention (TCA,Benadryl,increase BPH) 4. Diuretics -Polyuria (increase BPH s/s)

Question 38

The only herbal therapy which has modest increase but lacks sound data?

Answer 38

Saw Palmetto