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M3 Pharm B2 > Bradley: Antidepressants > Flashcards

Bradley: Antidepressants Flashcards

1
Q

SSRIs: Paroxetine

A

PTSD, short half-life can set stage for withdrawal

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2
Q

SSRIs: Fluoxetine

A

Very long half-life, prevents withdrawal

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3
Q

SSRIs: Citalopram

A

QTc prolongation

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4
Q

SSRIs: Escitalopram

A

QTc prolongation

S isomer, more biologically active

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5
Q

SSRIs: Nefazodone

A

Irreversible liver toxicity

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6
Q

SNRIs: Atomoxetine

A

ADHD

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7
Q

SNRIs: Duloxetine

A

Fibromyalgia, pain and depression

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8
Q

SNRIs: Venlafaxine

A

Effexor –> Most effective anti-depressant

Severe withdrawals: Shock parasthesias

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9
Q

TCAs/SNDRIs: Amitriptyline

A

Pain, migraine, eye pain

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10
Q

TCAs/SNDRIs: Clomipramine

A

FDA approved OCD

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11
Q

TCAs/SNDRIs: Doxepin

A

Antihistaminic for hives, insomnia

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12
Q

TCAs/SNDRIs: Imipramine

A

FDA approved for enuresis (bedwetting)

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13
Q

TCAs/SNDRIs: Protriptyline

A

Least sedating

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14
Q

MAOIs: Phenylzine

A

Non-selective MAOI (A and B)

AND

Irreversible (enzyme permanently inhibited until body make more)

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15
Q

MAOIs: Isocarboxazid

A

Non-selective MAOI (A and B)

AND

Irreversible (enzyme permanently inhibited until body make more)

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16
Q

MAOIs: Tranylcytopromine

A

Non-selective MAOI (A and B)

AND

Irreversible (enzyme permanently inhibited until body make more)

17
Q

MAOIs: Selegiline

A

Selective for MAO-B

18
Q

MAOIs inhibit degradation of which monoamine and this monoamine can do what to the body?

A

Inhibits degradation of Tyramine, which can elevate BP

19
Q

The Orphans: L-Methyl Folate

A

Useful for MTHFR insufficiencies

20
Q

The Orphans: Bupropion

A

Smoking cessation, sex life okay,

21
Q

The Orphans: Trazadone

A

Strongly inhibits post-synaptic alpha receptors

Priaprism, Low BP

22
Q

The Orphans: Mirtazapine

A

Somnolence
Increased appetite
Anxiety

Best ‘fit’ for anxiety, insomnia, and decreased appetite

M3 Pharm B2 (10 decks)

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