Brain tumors & neurocutaneous disorders

Question 1

pseudopalisading - cells with areas of central necrosis and hemorrhage

Answer 1

gliblastoma multiforme

Question 2

most common adult brain tumors

Answer 2

MGM Studios
Metastasis
Glioblastoma multiforme
Meningioma
Schwannoma

Question 3

whorled pattern, psammoma bodies (laminated calcifications)

Answer 3

Meningioma

Question 4

associated with NF2

Answer 4

schwannoma

Question 5

GFAP +

Answer 5

pilocytic astrocytoma, glioblastoma multiforme

Question 6

rosenthal fibers- eosinophilic corkscrew fiber

Answer 6

pilocytic astrocytoma

Question 7

compresses 4th ventricle causing hyrdocephalus

Answer 7

medulloblastoma, ependymoma

Question 8

homer-wright rosettes - small blue cells pink center

Answer 8

medulloblastoma

Question 9

perivascular pseudorosettes - basal ciliary bodies

Answer 9

ependymoma

Question 10

supratenoral childhood tumor, derived from remnants of rathkes pouch

Answer 10

craniopharyngioma

Question 11

compress CN III, eyes look down and out, dilated pupil

Answer 11

Uncal herniation, medial temporal lobe herniation past tentorium cerebelli

Question 12

port wine stains (nevus flemmus) with V1 distribution, also leptomeningeal angiomas and pheochromocytoma

Answer 12

Sturge-weber syndrome

Question 13

Harmatomas in CNS, ash-leaf hypopigmented spots, rhabdomyoma, mental retardation, renal angiomyolipoma, seizures

Answer 13

tuberous sclerosis

Question 14

cafe-au-lait hyperpigmented spots, lisch nodules (iris pigmented spots), optic glioma, pheochromocytoma, chrom 17

Answer 14

NF1

Question 15

AD, variable expression, 100% penetrant

Answer 15

NF1

Question 16

hemangiomas in skin and organs, bilateral renal cell CA, hemangioblastoma in retina, brainstem and cerebellum, pheochromocytoma,

Answer 16

von-Hipple-Lindau

Question 17

bilateral schwannoma, meningiomas, ependymomas

Answer 17

NF2

Question 18

drop metastises

Answer 18

medulloblastoma

Question 19

brainstem lesion resulting in pain and temperature loss on one side of face and opposite side of body. also dysarthria, dysphagia, ataxia

Answer 19

PICA - located on same side of facial lesion (wallenberg syndrome)

Question 20

brain tumor in frontal lobe with seizures, muscle weakness, fried egg appearance (clear cytoplasm with dense nucleus)

Answer 20

oligodendoglioma