Breast

Question 1

Incidence of breast cancer in India

Answer 1

1 in 21 women

Question 2

R/F for breast cancer

Answer 2

1. Age
2. Early menarche & late menopause
3. Family history
4. Nulliparity
5. Age at first delivery
6. Obesity, smoking, alcohol
7. HRT

Question 3

Etio of Breast cancer

Answer 3

90% sporadic
10% familial

Question 4

MC gene mutated in Breast cancer

Answer 4

P53

Question 5

Most common gene mutated in familial breast cancer

Answer 5

BRCA1

Question 6

Chromosomes for BRCA

Answer 6

BRCA1 - 17q
BRCA 2- 13q

Question 7

BRCA mutations cause what other cancers

Answer 7

Breast
Ovarian
male breast
Pancreatic
Colorectal
Primary peritoneal
Prostate

Question 8

BRCA 1 type

Answer 8

More agg
Poor prognosis
BASAL SUBTYPE
Mc- medullary ca

Question 9

BRCA 2 type

Answer 9

LUMINAL SUBTYPE
better prog

Question 10

BRCA 2

Answer 10

Luminal subtype
Better prog

Question 11

Risk reduction techniques

Answer 11

Bilateral prophylactic mastectomy (95% reduction but ovarian cancer 0% reduction)
B/L salpingo oophorectomy (ovarian 80% and breast 50%)
SERMS- tamoxifen by 47%

Question 12

Secretory apparatus of breast

Answer 12

Acini- lobule- lobe- drained by lactiferous duct—> nipple

Question 13

Functional unit of breast

Answer 13

TDLU

Question 14

Why upper outer quad Most common?

Answer 14

Becz 50% of ductolobular tissue is situated there

Question 15

Axillary tail of spence enters axilla through

Answer 15

Foramen of langer

Question 16

Involvement of ligament of copper

Answer 16

Dimpling

Question 17

Lig of cooper connects

Answer 17

Skin to pectoral fascia

Question 18

Polands syndrome

Answer 18

Amazia
Absence of sternal portion of pect major
Short webbed fingers

Question 19

Blood supply to breast

Answer 19

Internal mammary-60%
Axillary a- 30%

Question 20

Nerves related (during MRM)

Answer 20

Long thoracic
Thoracodorsal
Medial and lateral pectoral
Intercostobrachial

Question 21

Levels of ax nodes
(Based on p minor)

Answer 21

I- APL
II- central, rotters
III- apical

Question 22

Mammo views

Answer 22

CC & MLO

Question 23

Fibrocyastadenosis

Answer 23

Now called cyclical mastalgia with nodularity

Question 24

Fibrocystadenosis Features

Answer 24

Fluctuant, transilluminant, non tender, cystic with bluish capsule
Called BLUEDOME CYST OF BLOODGOOD

Question 25

Schimmelbusch’s disease

Answer 25

When diffuse small, multiple cysts are the main component of fibrocystadenosis. The MC breast disease

Question 26

Types of Fibrocystadenosis

Answer 26

Non prolif Prolif without atypia Prolif with atypia

Question 27

Stages Of Fibrocystadenosis

Answer 27

Stromal Prolif Gland prolif Cyst formation

Question 28

Treatment of Fibrocystadenosis

Answer 28

Oil of evening primrose Gamolenic acid Danazol Bromocriptine Tamoxifen

Question 29

MC non epithelial neoplasm of breast

Answer 29

Phyllodes

Question 30

Features of phyllodes swelling

Answer 30

Large Bosselated surface Smooth, soft, fluctuant Pressure Necrosis over summit Skin stretched, red and has dilated veins over it