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Breast Flashcards

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1
Q

Define breast cancer

  • What are the key types of breast cancer
  • Outline their progression
  • How many are ER +ve
A

Main types:
1) Invasive ductal carcinoma (80% of all BC)

2) Invasive lobular carcinoma (5-15%)

See the anatomy of the alveoli to understand that the cancer can come from the epithelial cells lining either the lobule or the duct

The general picture for both types, is that they originate in the terminal duct/lobular unit, and progress from an initial hyperproliferative stage, to a pre-invasive stage (known as carcinoma in situ) to invasive BC.

In the in situ stage, the tumour cells are confined to the duct and have not invaded beyond the duct wall.

-About 80% are oestrogen receptor positive

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2
Q

Explain the aetiology / risk factors of breast cancer

A

Genetic and environmental

Most polygenic risk with 5-10% attributable to inherited factors.

BRCA-1 (17q) and BRCA-2 (13q) gene mutatons implicated in 2% of cases (carriers have lifetime risk up to 87%).

Associations/risk factors:

  • Age
  • Prolonged exposure to female sex hormones (oestrogen in particular)
  • Nulliparity
  • Early menarche
  • Late menopause
  • Menopausal HRT
  • Obesity
  • Alcohol
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3
Q

Summarise the epidemiology of breast cancer

A

Breast cancer is the most common cancer in the UK accounting for 31% of all new cancer diagnoses (2014).

Breast cancer is the leading female cancer, accounting for almost 1 in 5 cancer deaths among women.

Breast cancer mortality is falling.

In the UK breast cancer is the second most common cause of death from cancer in women after lung cancer

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4
Q

Recognise the presenting symptoms of breast cancer

  • Primary cancer?
  • With secondary spread?
A

Symptoms of primary:

  • Breast lump (usually PAINLESS)
  • Changes in breast shape
  • Nipple discharge

Secondary spread:
-Axillary lump, bone pain, weight loss, paraneolastic syndromes (including cerebellar syndrome - paraneoplastic cerebellar syndrome occurs due to antibodies being produced against the breast tumour attacking the purkinje cells in the cerebellum)

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5
Q

Recognise the signs of breast cancer on physical examination

A

Inspect breasts with patients upright

Assess for:

  • Asymmetry
  • Peau d’orange (oedema in skin)
  • Dimpling or tethering
  • Nipple scaling or inversion or ulceration (in advanced cases)

-PALPATE USING CLOCKWISE RADIAL TECHNIQUE

Examination for palpable axillary, supraclavicular lymph nodes, chest abnormalities, hepatomegaly and bony tenderness

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6
Q

Identify appropriate investigations for breast cancer and interpret the results

What are the standard views on mammography

Which test is more useful in women older than and younger than 35.

Which tumour marker is used for breast cancer

A

Triple approach:
-Clinical examination, imaging (mammography, ultrasound, MRI) and tissue diagnosis (cytology or biopsy)

Mammogram (better in women >35) :

  • Cranio-caudal
  • Mediolateral oblique

Ultrasound (better in women <35):
-Identify benign cystic lesions from sinister solid lesions

Fine needle aspiration:
-minimally invasive, for cytology of discrete breast lump and drainage of cysts

Core biopsy:
-Can be image guided, enables histological diagnosis

Sentinel lymph node biopsy: radioactive tracer and/or blue die injected near breast lesion and a nuclear scan identifies if the sentinel node and the node is biopsied to detect spread

Staging: CT CAP, PET or bone scanning for mets

CA-15-3: Cancer antigen 15-3 (CA 15-3) is a normal product of breast cells. Concentrations of CA 15-3 in the blood are often increased in breast cancer.

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7
Q

Outline normal anatomy of the breast:

  • Glands?
  • Cell types
  • Vasculature?
  • Lymph drainage?
A

Overall, you have mammary gland (composed of lobules and lactiferous ducts) and connective issue.

Mammary gland:

1) 15-20 secretory lobules which each composed of many alveoli
2) network of lacterous ducts (one for the drainage of each lobule)

Connective tissue:

1) Fibrous component= suspensory ligaments of cooper. -Separate out lobules
- Attach and secure breast to dermis and underlying pectoral fascia
2) Fatty component
- —————————————————-

Medial part of breast supplied by internal thoracic artery (branch of subclavian)

Lateral part of breast supplied by:
1) Lateral thoracic and thoracoacromial branches – originate from the axillary artery.

2) Lateral mammary branches – originate from the posterior intercostal arteries (derived from the aorta).
3) Mammary branch – originates from the anterior intercostal artery.

Majority of lymph drained through the axillary lymph nodes (75%).

Some lymph drains to following lymph nodes:

  • Parasternal (20%)
  • Posterior intercostal (5%)

Nipple and areola – drains to the subareolar lymphatic
plexus

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8
Q

Overall management of breast cancer

A
  1. Surgery
  2. Radiotherapy
  3. Chemotherapy
  4. Endocrine therapy
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9
Q

Outline the types of endocrine therapy used in breast cancer treatment

A
  1. Suppressing ovaries
  2. Blocking oestrogen production by enzymatic inhibition
  3. Inhibiting oestrogen action
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10
Q

Outline ovarian ablation

A

Previously was done surgically removing/by irradiation of ovary

Now can be done at the level of pituitary reversibly using LHRH AGONISTS

The reason it works is because it binds to LHRH receptors in the pituitary gland, leading to receptor down regulation and suppression of LH release and thus inhibition of ovarian function including oestrogen production

e.g. goserelin, leuprolide

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11
Q

Outline how breast cancer can be treated by inhibiting oestrogen action

A

Anti-oestrogens

Tamoxifen is a competitive inhibitor of estradiol binding to the ER

Antiestrogens negate the stimulatory effects of estrogen by blocking the ER, causing the cell to be held at the G1 phase of the cell cycle.

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12
Q

What is commonest side effect of tamoxifen

What are the negative effects

A

Few side effects reported - hot flushes (29%) most commonly reported during Tamoxifen therapy.

Increase incidence of endometrial cancer

Stroke

Deep Vein Thrombosis

Cataracts

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13
Q

Outline how oestrogen production can be reduced using enzymatic inhibition

A

This refers to the peripheral conversion of androgens into oestrogens in post menopausal women. In these women, aromatase inhibitors can be used to stop the production of the small amount of oestrogen usually converted from androgens

It isn’t used as much in pre-menopausal women, because most of their estrogen comes from the ovaries.

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14
Q

A 50-year-old woman comes to the physician’s office with a chronic eczematous dermatitis of the left nipple and areolar area for past 24 months. Her history reveals the lesion has been treated unsuccessfully with topical steroids and has progressively distorted the nipple, resulting in inversion of the nipple. Physical examination reveals scaly, crusted, and deformed left nipple with multiple plaques overlying the surrounding areola.

A

Paget’s disease of the breast

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15
Q

What is paget’s disease of the breast

A

Paget disease of the breast is a pathologic hallmark of malignant, intraepithelial adenocarcinoma cells within the epidermis of the nipple.

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16
Q

What is the diagnositc imaging for paget’s disease of breast

A

Diagnostic work-up should include a careful examination of both breast and mammography.

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17
Q

Presenting features of pagets disease of the breast

A

Eczematous changes of the nipple, along with distortion, scaling, crusting, and plaque formation are classic presenting features of this disease. The symptoms usually affect the nipple, then spread to the areola and eventually the breast. Symptoms commonly wax and wane.

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18
Q

How can you differentiate pagets disease of breast from eczema

A

Pagets: The symptoms usually affect the nipple, then spread to the areola and eventually the breast

Eczema tends to affect the areola first, then the nipple.

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19
Q

Outline investigation of a breast lump in a young demale

A

To confidently exclude breast cancer, lumps should under go triple assessment:

1) Clinical examination
2) Radiological examination
- YOUNG WOMEN <35 should be an USS
- WOMEN >35 should be a two view mammmogram

3) FNA

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20
Q

Define fibroadenoma

A

Non malignant lesion of the breast

Hyerplasia of a breast lobule, contains both normal epithelial and connective tissue elements

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21
Q

Explain the aetiology / risk factors of fibroadenoma

A

Most common breast mass in women <35 years old

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22
Q

Summarise the epidemiology of fibroadenoma

A

.

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23
Q

Recognise the presenting symptoms of fibroadenoma

A

A non-tender, mobile mass

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24
Q

Recognise the signs of fibroadenoma on physical examination

A

Fibroadenomas are usually smooth, well-circumscribed and mobile limbs (1-2cm in diabeter), a “ breast mouse”

Solitary, rubbery, mobile, non-tender

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25
Identify appropriate investigations for fibroadenoma and interpret the results Calficiation on imaging is more likely to suggest which kind of pathology
Triple assessment 1) Clinical examination 2) Mammography, or USS in younger patients (<35yo). Benign masses are less likely to be calcified (microcalcifications are highly suggestive of MALIGNANCY) 3) Cytology/histology: by FNA cytology, or trucut or excision biopsy If you’re under 30 and diagnosed with a fibroadenoma through ultrasound, biopsy might not be needed. Your doctor can check on it with physical exams and ultrasounds to see if it changes or grows. If you’re in your 30s or older, your doctor may recommend a needle biopsy to confirm the diagnosis.
26
Generate a management plan for fibroadenoma
They can be treated conservatively or removed surgically if large (or on request) Conservative: REGULAR CHECK UPS
27
Identify the possible complications of fibroadenoma and its management
Pain, recurrence Over time, a fibroadenoma may grow in size or even shrink and disappear. The average fibroadenoma is anywhere from the size of a marble up to 2.5 centimeters (cm) in diameter. If it grows to 5 cm or larger, it’s called a giant fibroadenoma.
28
Summarise the prognosis for patients with fibroadenoma T/F there is a small risk of a fibroadenoma becoming cancerius
Good prognosis. Fibroadenomas have NO increased risk of cancer in women with a simple fibroadenoma AND no family history of breast cancer Higher estrogen levels due to pregnancy or hormone therapy can cause a fibroadenoma to get bigger, while menopause often causes it to get smaller However, there appears to be a slight increase in risk with a “complex fibroadenoma.” This is a fibroadenoma that includes one or more of the following benign elements: cysts larger than 3 millimeters; sclerosing adenosis; epithelial calcifications; or papillary apocrine change.
29
Smoking is a risk factor for which benign breast conditions
Periductal MASTITIS
30
Benign breast lumps are less common in which patients
Those on the contraceptive pill
31
Lumpy breasts which can be painful, especially just before the period
Fibrocystic disease is a very common benign breast condition characterised by lumpy breasts which can be painful. The pain is typically at its worst immediately before the patient’s period and is relieved when the period arrives.
32
Breast abscesses are associated with which risk factorrs
Breastfeeding and smoking
33
Duct ectasia key buzzword?
Duct ectasia is a condition in which the lactiferous ducts get blocked. The classic SBA buzzword of duct ectasia is a ‘cheesy yellow/green discharge’.
34
In breast cancer biopsy, are core biopsies or FNAs more commonly performed
Core biopsies are usually performed instead of FNA’s as more detailed information such as ER and PR status and HER2 can be obtained.
35
T/F a full staging assessment is required in patients with early stage breast cancer
Most patients with early stage breast cancer do not require baseline staging tests, as the detection rate is very small. If however, the patient has symptoms that may be suspicious for possible metastases then a FBC, U&Es, LFTs and bone profile would be appropriate.
36
T/F the age of the patient is an important consideration in assessing breast cancer patients for surgery
F The age of a patient is irrelevant when planning surgical treatment. The patient has to be assessed as to their physical fitness
37
Which additional therapy is given to cancer patients following wide local excisios
A wide local excision involves excising the tumour with surrounding normal breast tissue to ensure good margins are achieved (breast conservation surgery). Radiotherapy is given to the breast tissues as an adjuvant post-surgery to prevent local recurrence
38
How does lobular carcinoma act differently to ductal?
Invasive lobular carcinoma is less common accounting for 15% of cases. It behaves in the same way as ductal carcinoma although it has the tendency to be bilateral and multi-focal.
39
How do breast cysts present
Can be tender lump, appearing suddenly. Mobile and smooth, may or may not be fluctuant. Cysts are often an incidental finding during the screening process.
40
What is the cause of a cyst Risk factors for breast cyst
They are distended and involuted lobules. Cysts account for around 15% of all discrete breast masses and are more common in perimenopausal women. They are uncommon after the menopause.
41
T/F carcinomas can appear within cysts. USS is good at visualising this
T The proportion of cystic lumps which contain an intracystic carcinoma is relatively low and ultrasound is now of such high quality that it would be unusual to miss an intracystic carcinoma at ultrasound examination.
42
What does a breast cyst look like on mammography
Cysts have a characteristic halo on mammography and have a smooth round appearance. They are often multiple and bilateral.
43
What are the investigations for breast cyst
1. Clinical examination | 2. Mammography --> USS.
44
What do breasts cysts look like on USS Differentiate it to fibroadenoma
Cysts show up as transparent objects. They have well demarcated edges and have posterior acoustic enhancement Benign solid lumps, such as fibroadenomas, show as having well defined edges with internal echoes
45
How are symptoms relieved from a painful breast cyst
Fine needle aspirations of a cystic lesion will relieve symptoms. It is often done under ultrasound guidance Whilst cysts can be safely left in situ, it is best practice to aspirate the cyst at first presentation as this will not only confirm the diagnosis but also give the patient relief from both the physical symptoms and also from the anxiety of having a breast lump
46
T/F aspirated fluid from symptomatic cysts should be sent for cytology
Cyst fluid is not sent for cytology unless uniformly bloodstained
47
T/F HRT can worse breast cyst symtpoms
T HRT would not resolve the symptoms of breast cysts. HRT can in fact exacerbate the symptoms. Cysts are common breast lumps in perimenopausal women and are uncommon after the menopause. Therefore HRT would just prolong the symptoms.
48
t/f breast cysts are usually hormone dependenT
T
49
"Smooth mobile and painless lump" most likely differential
Fibroadenoma
50
Uusal presentation of a fibroadenoma
The usual age of first presentation of a fibroadenoma is adolescence to around 30 years but patients may notice a fibroadenoma when some of the glandular tissue starts to decrease from around the age of 35 years
51
T/F having a grandmother who died of breast cancer at the age of 75 increases your own risk for breast cancer
F Patient’s risk of developing breast cancer is the same as the average population as grandmother is a second degree relative who was postmenopausal at diagnosis.
52
T/F fibroadenomas develop from a whole lobule rather than a single cell
Fibroadenomas are best considered as aberrations of normal development and involution (ANDI) Fibroadenomas develop from a whole lobule whereas neoplasms arise from a single cell It's confusing because most textbooks classify fibroadenomas as benign neoplasms
53
T/F fibroadenomas show hormone dependence
T Fibroadenomas show the same hormonal dependence as the remainder of breast tissue, for example they may increase in size during pregnancy and involute during the perimenopausal period.
54
A new breast lump appears in a woman after menopause, is fibroadenoma a differential?
No. Fibroadenomas do not appear as new lesions after the menopause. The fibroadenomas that are picked up on screening and are likely to have been there for several years
55
What does fibroadenoma look like on USS
fibroadenomata are typically well defined, homogeneous, with a lobulated margin and contain internal echoes.
56
T/F FNA can histologically classify the lesion
F... core needle biopsy is required for that FNA can differeniate cystic and solid lesions, and differentiate benign and malignant cells only
57
What are the indications for excision of a fibroadenoma
If the clinical assessment, imaging and biopsy confirm a benign fibroadenoma then the patient can be reassured and discharged. If the lump is > 2cm and visible then it may be appropriate to excise it if the patient requests excision. If there is evidence that the lump is increasing in size then it would be appropriate to excise it. If the biopsy raises suspicion that this is a phyllodes tumour then the lump should be excised with a margin to make a definitive diagnosis, as phyllodes tumours may recur.
58
When can phsiological gynaecomastia occur
Physiological gynaecomastia occurs primarily in newborns and adolescents at puberty and usually will resolve spontaneously
59
Pathalogical gynaecomastia causes
Testicular issues: -Primary testicular failure, anorchia, bilateral cryptorchidism, acquired testicular failure Drug Hepatic disease
60
Drugs causing gynaecomastia
Testosterone target cell inhibitors – cimetidine, cyproterone acetate Proton pump inhibitors Anabolic steroids Marijuana Heroin Oestrogens and oestrogen agonists – digoxin, spironolactone Hyperprolactinaemia – methyldopa, phenothiazines
61
Describe the enlargement of the breast in gynaecomastia
Enlargement is usually central and symmetric.
62
t/f drug related gynaecomastia is usually unilateral, as is idiopathic
T
63
t/f Pubertal and hormonal cases of gynaecomastia are usually bilateral
T
64
T/F digoxin can cause gynaecomastia
T
65
What is inflammatory breast cancer
Inflammatory breast cancer is a rare but highly aggressive form of locally advanced breast cancer.
66
What is the presentation of inflammatory breast cancer
linically it is characterised by the rapid onset of breast warmth, erythema and peau d’orange (skin of an orange) and often without a definite mass. Along with extensive breast involvement, women with inflammatory breast cancer often have early involvement of axillary nodes.
67
Characteristic pathological finding with inflammatory breast cancer
The characteristic pathological finding is dermal lymphatic invasion by carcinoma, which can lead to obstruction of lymphatic drainage causing the clinical appearance of erythema and oedema.
68
t/f patients that express HER2 breast cancer have a shorter survival
T
69
Staging test for inflammatory breast tumours
First line investigations will include blood tests to assess liver function and bone health. Ca 15-3 is a tumour marker which can be used to assess response to treatment. CT chest/abdo Bone scan CXR Abdominal ultrasound
70
Treatment for inflammatory breast cancer
The initial treatment is neo-adjuvant (primary) chemotherapy which is usually anthracycline based. This will be usually be followed by surgery and Herceptin treatment if patient has a HER-2 Positive cancer.
71
Small lump near the nipple + blood stained discharge
An intraductal papilloma is a benign tumour that forms within the milk ducts of the breast. It presents as a small breast lump near the nipple, often accompanied by a blood-stained nipple discharge.
72
Classify the 2 types of breast abscesses
Breast abscesses can be divided into lactational (occurring in women who are breastfeeding) and non- lactational (typically occurring in 30 to 60-year-old women who smoke). It presents with a painful breast swelling which may have an overlying area of erythema. These patients are also likely to have a fever and feel generally unwell.
73
What are the examination characteristics of a phyllodes tumour
Large, multilobular shape, usually mobile, firm
74
Histology of phyllodes tumor
Phyllodes tumors are uncommon breast masses that are histologically similar to fibroadenomas , but are characteristically much larger and rapidly expanding. ``` Phyllodes tumors have a leaf -like architecture with elongated cleft-like spaces that contain papillary projections of epithelial-lined stroma with varying degrees of hyperplasia and atypia , allowing differentiation from fibroadenoma . ```
75
"small uniform cells arranged in single file pattern"
Lobular carcinoma is characterized by this histological pattern. There are neoplastic cells with limited cohesiveness in a single file infiltrating pattern.
76
"neoplastic epithelial cells in the mammary ductal system"
``` Neoplastic epithelial cells within the mammary ductal system describe ductal carcinoma . Ductal carcinoma in situ is diagnosed if there is no invasion into the surrounding stroma. ```
77
"Fibroelastic core with surrounding compressed tubular structures"
This histologic pattern can be found in radial scars (also known as complex sclerosing lesions). These are benign breast lesions, but may be excised in order to exclude malignancy.
78
"poorly differentiated cells and a high level of lymphocytic infiltrates seen on biopsy."
MEDULLARY carcinoma
79
``` "biopsy of the lesion will reveal cells with prominent nucleoli surrounded by an abundant pale cytoplasm , resembling a halo" ```
pagets disease of breast ``` Patients with Paget disease of the breast have painful, eczematous lesions over the nipple that sometimes extend into the areola . These lesions can be vesicular, ulcerative, or scaly, and patients can have bleeding in addition to pain and/or pruritus. Paget disease of the breast is a condition associated with an underlying breast carcinoma . ```
80
Most common benign breast lesion
"Fibrocystic changes" Which are tender breast nodules which can worsen around the tim eo fthe period Premenstrual bilateral breast pain
81
T/F clear or milky discharge can occur with fibrocystic changes
T Clear or slightly milky nipple discharge
82
Investigation for fibrocystic changes
Physical changes USS/mammogram (age dependent)- shows normal appearance (clear borders, dispersed calcification) FNA (after imaging confirms cystic lesions- if patient symptomatic) Aspiration of clear, nonbloody fluid that results in complete resolution of the lesion confirms the diagnosis of a simple cyst Biopsy confirms diagnosis if unsure from imaging
83
What might imaging for fibrocystic changes show
Cysts: dilated, fluid filled ducts (blue dome cysts) Stromal fibrosis (no malignant potential) Slcerosing adenosis (proliferation of small ductules and acini in the lobules, calcifications (slightly increased risk of breast cancer)) Ductal hyperplasia (papillary proliferation, apocrine metaplasia, epithelial hyperplasia of terminal ducts cells- presence of atypical cells associated with increased risk of breast cancer)
84
A unilateral tender, firm, swollen, rest breast
Mastitis
85
Most common demographic affected by mastitis
Breastfeeding mothers! Up to 10% of nursing mothers (particularly 2–4 weeks postpartum) experience
86
Most common causative organism for mastitis
``` Staphylococcus aureus (most common) Other pathogens (Streptococcus, Escherichia coli) are rare. ```
87
Cause of mastitis
Woman has nipple fissure (e.g. due to incorrect latching) + prolonged breast engorgement (due to milk overproduction of insufficient drainage due to infrequent feeding) + Bacteria located in the nostril and throat of the infant or on the skin of the mother enter milk ducts during breastfeeding and the pathogen flourishes in stagnant milk and causes tissue inflammation
88
Investigations for mastitis?
Clinical diagnosis Breast milk cultures or imaging may be required if there is no response to initial treatment. Breast USS helps identify abscess, which form a hypoechoic lesion
89
Management of mastitis?
LACTATIONAL. -If negative culture/symptoms not severe, give paracetemol and ensure effective milk removal -If symptoms continue more than 12hr, or positive culture, give Abx. E.g. flucloxacillin/clindamycin If there is no improvement within 48hr time frame, breastmilk culture and assay of antibiotic sensitivities should be ordered, and the possibility of alternative diagnoses considered. (if MRSA- use vancomycin/trimethoprim)
90
What is the main complication of mastitis
Breast abscess
91
What is a breast abscess
an encapsulated accumulation of pus within the breast tissue.
92
Compare features of mastitis and breast abscess
Mastitis: Tender, firm, swollen, erythematous breast (generally unilateral) Pain during breastfeeding Reduced milk secretion Flu-like symptoms, malaise, fever, and chills In some cases, reactive lymphadenopathy ``` Abscess: Breast pain, erythema, and edema Purulent discharge from the nipple of the affected breast Fever Nausea Fluctuating mass on palpation ``` Fluctuant mass
93
T/F patients with mastitis should continue breastfeeding
T. Patients with mastitis should continue breastfeeding to reduce the risk of a breast abscess!
94
What is the treatment of a breast abscess
NEEDLE ASPIRATION with or without USS guidance. Multiple aspirations may be necessary. Send for culture and cytology. The risk of failure for needle aspiration is greater with abscesses >5 cm in diameter Incision and drainage is reserved for patients in whom aspiration fails after several attempts (guidance suggests at least 3-5 attempts) or for large abscesses PLUS IV or oral Abx with activity against S. Aureus E.g. flucloxacillin/clindamycin
95
Single lesion, bloody nipple discharge Palpable mass behind the nipple How is the diagnosis made
Intraductal papilloma Core needle biopsy
96
t/f papillomas are only solitary lesions
F
97
What is an intraductal papilloma
solitary or multiple benign lesions that arise from the epithelium of breast ducts
98
Peak incidence of intraductal papilloma
40-50 years
99
Where are solitary vs mutliple papilloma located
Solitary located centrallly Multiple located peripherally
100
What are the clinical features of a solitary intraductal papilloma lesion
Most common cause of bloody nipple discharge Large, central lesion Palpable breast tumor close to or behind the nipple
101
What are the clinical features of a multiple intraductal papilloma lesions
Usually asymptomatic but may cause nipple discharge in rare cases Peripheral lesions; smaller than solitary papilloma
102
How to make the diagnosis of papilloma
Core needle biopsy | use ductogram if the lesion isn't palpable
103
Prognosis for papilloma
For most of the lesions, there is no risk of malignant transformation. However, lesions with atypical hyperplasia are associated with an increased risk of breast cancer
104
Near menopausal woman, unilateral green bloody discharge with nipple invasion and a painful mass under the nipple
Mammary duct ectasia
105
What is mammary duct ectasia
subareolar periductal chronic inflammatory condition defined by dilated mammary ducts which are eventually clogged
106
Cause of mammary duct ectasia
inspissated luminal secretion stasis leading to periductal inflammation and fibrous obliteration
107
Who is mammary duct ectasia most common in
Perimenopausal women (40-50)
108
Clinical features of mammary duct ectasia
Unilateral greenish or bloody discharge Nipple inversion Firm, stable, painful mass under the nipple (may mimic breast cancer) May progress to a breast abscess
109
How can mammary duct ectasia be diagnosed
Mammogram and/or ultrasound: noninvasive imaging modalities can determine duct diameter If any suspicious or inconclusive imaging findings, perform a biopsy: shows a
110
"central cavity filled with neutrophils and secretion surrounded by inflamed and/or fibrotic breast parenchyma, with obliteration of the ducts" found from a biopsy of a breast
mammary duct ectasia
111
What is a galactocoele
milk retention cyst located in the mammary gland
112
Most common benign breast lesion in lactating women is
Galactocele
113
What is the pathophysiology of galacotcele
obstruction of lactiferous duct → distention of the duct due to collection of milk and epithelial cells → cyst formation
114
Clinical features of a galactocele
Soft, nontender mass; typically located in the sub-areolar region Pain suggests secondary infection.
115
How to make the diagnosis of galactocele
Primarily a clinical diagnosis Fine needle aspiration: milky substance (diagnostic and therapeutic) Ultrasound: complex mass; findings depend on the fat and water content of the cyst Mammography (rarely indicated): galactoceles may appear as an indeterminate mass or a mass with the classic fat-fluid level
116
T/F DCIS is palpable
F
117
T/F paternal history is relevant for breast cancer
T
118
T/F breast abscess most commonly occurs most partum
T
119
T/F breast cysts most common 4th decade
T | it is most common in 20-40 age group.
120
Normal fluid in breast cyst?
Usually fluid filled
121
T/F paget's disease of the hbreast can lead to secondary sarcoma development
F Paget's disease (of the bone) can do so. Paget's disease of the nipple is a unilateral eczema of the nipple due to destruction of the nipple by ductal spread of carcinoma.
122
Treatment of paget's disease?
Is best treated by mastectomy and axillary clearance.
123
T/F chest x-rays are done for early breast cancer
T`
124
T/F FNA should be performed on EVERY breast lump
T
125
What is the breast lump triple assessment
1. Clinical Hx and Examination 2. Radiology ultrasound if <35 y/o mammography and USS if >35 y/o 3. Histology/Cytology (FNA / core biopsy) 1. Cystic lump- aspirate: - CLEAR FLUID: discard and reassure patient - BLOODY FLUID: send for cytology - RESIDUAL MASS FOUND: core biopsy 2. Solid lump- core biopsy and histology

Year 3 (18 decks)

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