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MRCP -oncology > breast cancer > Flashcards

breast cancer Flashcards

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18
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where does breast cancer most of the time metastise too ?

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, bone metastases are most likely to originate from the breast. In men, bone metastases are most likely to originate from the prostate.

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20
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what is Trastuzumab

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monoclonal antibody directed against the HER2/neu receptor

21
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Role of Trastuzumab

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mainly in metastatic breast cancer although some patients with early disease are now also given trastuzumab.

22
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side effects of Trastuzumab

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flu-like symptoms and diarrhoea are common

cardiotoxicity:
more common when ANTHRACYCLINES HAVE also been used
an echo is usually performed before starting treatment

23
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Selective oEstrogen Receptor Modulators (SERM) example and used when ?

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Tamoxifen- used in the management of oestrogen receptor-positive breast cancer.

24
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Tamoxifen is a SERM which acts as an

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oestrogen receptor antagonist and partial agonist

25
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Adverse effects of elective oEstrogen Receptor Modulators (SERM)

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menstrual disturbance: vaginal bleeding,

amenorrhoea

hot flushes - 3% of patients stop taking tamoxifen due to climacteric side-effects
venous thromboembolism

endometrial cancer

26
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examples of aromatase inhibitors ?

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Anastrozole and letrozole

27
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function of aromatase inhibitor ?

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reduces peripheral oestrogen synthesis.

28
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aromatisation accounts for the majority of oestrogen production in ?

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postmenopausal women and therefore anastrozole is used for ER +ve breast cancer in this group.

29
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side effects of aromatase inhibitor such as anastrozole and letrozole

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osteoporosis
NICE recommends a DEXA scan when initiating a patient on aromatase inhibitors for breast cancer
hot flushes
arthralgia, myalgia
insomnia

MRCP -oncology (14 decks)

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