Breast + Endometrial + Ovarian Cancer

Question 1

Definition of early stage breast cancer (Stage I or II)

Answer 1

Tumour <4cm
AND
Node negative on pre-operative workup

Question 2

Definition of locally advanced breast cancer (stage III)

Answer 2

Tumour >4cm
OR
Node positive on pre-op work up

Question 3

Most favourable breast cancer receptor status

Answer 3

ER/PR positive
HER2 negative

Question 4

Treatment of Early Stage Breast Cancer

• What is the standard of care
• 4 reasons to pick mastectomy
• What to next if sentinel node biopsy is positive

Answer 4

Endocrine therapy is still the mainstay of adjuvant therapy for HR-positive, HER2-negative early breast cancer.

Question 5

T-DM1 most notable SE

Answer 5

Thrombocytopenia!

Question 6

Risks of Cancer in BRCA1 female carriers

Answer 6

Question 7

Risk of cancer in BRCA2 female carriers

Answer 7

Question 8

Male BRCA1 or 2 carrier recommendations

Answer 8

Question 9

ER Positive Endocrine Treatments in Breast Ca

Answer 9

SERM - selective estrogen receptor modulator

Question 10

Is mastectomy equivalent to WLE in early stage breast cancer

Answer 10

Yes

Question 11

Tamoxifen

Answer 11

Actually INCREASE BMD

Question 12

Aromatase inhibitors

Answer 12

give with a bisphosphonate!

Question 13

PARP Inhibitors

Answer 13

Question 14

Pathological Types of Endometrial Ca

Answer 14

Question 15

Treatment of Cervical Ca

Answer 15

Question 16

Breast Cancer Screening

Answer 16

Question 17

Clinical RF of Hereditary Breast Ca

Answer 17

Question 18

What to offer BRCA patients

Answer 18

Question 19

Chemotherapy agents of early stage breast Ca

• Names/Classes
• Main short and long term toxicities

Answer 19

Doxorubicin cardiotoxicity is generally irreversible

Question 20

Surgical Management of Early Breast Ca

Answer 20

Question 21

DCIS vs LCIS

Answer 21

Question 23

BRCA 1 female carrier recommendations

Answer 23

Question 24

Lifetime risk of Cancer in BRCA1 or BRCA2 positive males

Answer 24

Question 25

Treatment of Ovarian Cancer

Answer 25

Question 26

Endometrial Cancer Risk Factors - biggest risk factors - 3 major other risk factor/type

Answer 26

Question 27

HER2+ early stage Breast Ca adjuvant treatment:

Answer 27

**Cardiomyopathy** caused by **Trastuzumab is reversible**

Question 28

Treatment of Metastatic Breast Ca

Answer 28

Question 29

**Late recurences** are a feature of what type of breast ca?`

Answer 29

**Hormone receptor positive breast cancer** - particularly **in bone**

Question 30

Strongest poor prognostic marker in breast cancer

Answer 30

Question 31

Pathological Types of Ovarian Cancer

Answer 31

Question 32

BRCA2 female carrier recommendations

Answer 32

Question 33

Presentation, Dx and Treatment of Endometrial Ca

Answer 33

Question 34

What are the indications for chemo in early stage breast ca?

Answer 34

* Node Positive cancer * High risk features which can be applied to node negative tumours - grade 3, extensive PVI, size \>4cm, weak ER/PR expression

Question 35

Staging of Endometrial Ca

Answer 35