Breast Lump Flashcards

(33 cards)

1
Q

What are the four most common diagnoses for a breast lump

A

Benign cystic change/fibroadenosis
Fibroadenoma
Cyst
Carcinoma

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2
Q

What are the most common diagnoses of a breast lump in patients <30

A
Physiologically normal, lumpy
Benign cystic change
Fibroadenoma
Abscess (if breastfeeding)
Galactocele (If breastfeeding)
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3
Q

What are the most common diagnoses of a breast lump in patients 30-45

A

Benign cystic change
Abscess (esp. smokers)
Carcinoma

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4
Q

What are the most common diagnoses of a breast lump in patients 45-60

A

Cyst
Abscess (esp. smokers)
Carcinoma

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5
Q

What are the most common diagnoses of a breast lump in patients >60

A

Carcinoma

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6
Q

What are galactoceles and how do they present

A

Caused by obstruction of a lactiferous duct -> become sdistended with milk + epithelial cells
Present as a firm mass (often subareolar) during or shortly after cessation of breastfeeding. Very similar to a cyst on exam.
May become infected -> abscess formation

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7
Q

What are the common causes of mastitis

A

Skin commensals e.g. S. aureus or staph. epidermis in lactating women
Anaerobic in older women (periductal)

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8
Q

What are the important risk factors for breast cancer

A
Being female and increasing age
Previous breast cancer
Family history of breast cancer
Previous ovarian, endometrial or bowel cancer
Irradiation to the chest wall
Increased exposure to oestrogens
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9
Q

What may cause increased exposure to oestrogens

A
Early menopause (<13) or Late (>51)
Nulliparity 
Having a first child after 30
Not breast-feeding
HRT
COCP use
Obesity
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10
Q

What questions should be asked about a breast lump

A
How long has the lump been there, when was it noticed
Breast trauma?
Changes in size, any relating to menses
Painful lump
Any skin changes
Any discharge or nipple changes
Risk factors and general health
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11
Q

What can the length of time a lump has been there tell you

A

Very quick - abscess or cyst

Longer period - fibroadenoma or carcinoma

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12
Q

What is the association between breast trauma and any lumps

A

Trauma, accidental or iatrogenic, can predispose to fat necrosis and infective sequelae e.g. abscess

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13
Q

What does the changes in size to a breast lump tell you

A

Abscesses and cysts can change size very rapidly

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14
Q

What can pain tell you about a breast lump

A

Benign cystic change, acute mastitis and abscesses classically cause pain and tenderness

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15
Q

What do skin changes on the breast tell you

A

Warm erythematous skin - mastitis or abscess or inflamed carcinoma

Peau d’orange (puckering) suggests carcinoma

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16
Q

What do changes to the nipples ± discharge (blood, milk, coloured, serous) tell you

A

Recent nipple change - carcinoma

Blood - carcinoma
Milk - galactocele
green/brown/yellow - periductal mastitis from duct ectasia
Serous/seroanguinous - intraductal papilloma

17
Q

What does back pain with a breast lump suggest

A

Sign of metastases to the spine

18
Q

What should be looked for on breast exam

A
Asymmetry 
Contours
Skin changes (erythema, ulceration, dimpling, radiotherapy tattoo)
Nipple changes or discharge
19
Q

What would a solitary cyst feel like on palpation

A

Smooth, distinct borders, firm-lax, not mobile or fixed

No lymphadenopathy

20
Q

What would a fibroadenoma feel like on palpation

A

Smooth, distinct borders, rubbery, mobile, not fixed

No lymphadenopathy

21
Q

What would a benign cystic change feel like on palpation

A

Irregular, indistinct borders, mixed consistency, NOT mobile or fixed
No lymphadenopathy

22
Q

What would a carcinoma feel like on palpation

A

Irregular, indistinct borders, hard consistency, NOT mobile, may be fixed and may have lymphadenopathy

23
Q

What is a fibroadenoma

A

Aberrations of normal breast development that contains stromal and epithelial elements
7-30% of young women will have one at some stage

24
Q

How are all solid lumps investigated in a breast clinic

A

Clinical examination
Radiological examination (USS <35yrs, mammography otherwise)
Fine needle aspiration or core biopsy

25
What are the treatment options for a fibroadenoma
Either leave it to resolve or excision biopsy
26
Where do breast carcinomas often metastasise to and which are investigated
Lungs Liver Bone Brain Liver and bone is always investigated, lung and brain only if they are clinically suspected
27
``` How are the following investigated for metastases from the breast: Lungs Liver Bone Brain ```
Liver: CT/MRI abdomen Bone: axial skeleton bone scintigraphy or CT/MRI AND imaging of long bones via scintigraphy or radiograph. Blood tests (Ca2+, ALP, phos) Lungs: CT Brain: CT
28
In general, what treatments are available for a breast carcinoma
Surgery or radiotherapy | Chemo, hormonal therapy, monoclonal Abs e.g. herceptin
29
What is the management for a breast abscess
Antibiotics Refer to surgeons for drainage Smoking cessation
30
What are some causes of gynaecomastia
Liver disease Drugs e.g. cimetidine, spironolactone, phenothiazines, finasteride, steroids Primary/acquired/secondary testicular failure Endocrine tumours e.g. pit, testicular, adrenal Non-endocrine tumour e.g. bronchial
31
What are the advantages and disadvantages of fine needle aspiration
Quick, minimally invasive Low risk of bruising or local complications Adequate to assess hormone receptor status May have poor sensitivity. In situ and invasive disease cannot be differentiated
32
What are the advantages and disadvantages of core biopsy
In situ and invasive disease can be differentiated Higher risk of local complications and bruising Results are not immediate Requires more local anaesthesia, more invasive and time-consuming
33
What methods exist for axillary staging of breast cancer
``` Axillary clearance (remove local lymph nodes) Axillary sampling (minimal dissection of the axilla, at least 4 nodes removed) Sentinel lymph node biopsy (injeciton of blue dye and/or radio-isotope into the periareolar tissue) ```