Breast Pathology

Question 1

Nipple diseases

Answer 1

Paget; Abscess

Question 2

Lactiferous Sinus Diseases

Answer 2

Intraductal papilloma; abscess and mastitis

Question 3

Major Duct Diseases

Answer 3

Fibrocystic change; DCIS; invasive ductal carcinoma

Question 4

Terminal Duct Diseases

Answer 4

Tubular carcinoma

Question 5

Lobule Diseases

Answer 5

Lobular Carcinoma

Question 6

Breat Stroma Diseases

Answer 6

Fibroadenoma; phyllodes tumor

Question 7

Small, mobile firm mass with sharp edges; Not a precursor to breast cancer

Answer 7

Fibroadenoma

Question 8

Small tumor that grows in lactiferous ducts typically beneath areola; serous or bloody nipple discharge

Answer 8

Intraductal papilloma

Question 9

“leaf like projections” most common in 50s

Answer 9

Phyllodes Tumor

Question 10

Large bulky mass of CT and cysts

Answer 10

Phyllodes Tumor

Question 11

Overexpression of c-erbB2 (HER-2)

Answer 11

Malignant breast tumor

Question 12

LN used to indicated breast cancer metastasis

Answer 12

Axillary

Question 13

Triple Negative breast cancer

Answer 13

ER (-); PR(-); and Her2/Neu (-)

most aggressive

Question 14

BRCA1

Answer 14

Breast and Ovarian Carcinoma (medullary breast)

Question 15

BRCA2

Answer 15

Breast carcinoma (in men too)

Question 16

Most common male breast cancer

Answer 16

Invasive ductal carcinoma; assoc with BRCA2 and Klinefelter

Question 17

Ductal Carcinoma In Situ (DCIS)

Answer 17

Fills ductal lumen; arises from ductal atypia; microcalcifications on mammography

Question 18

Ductal caseous necrosis; dysmorphic calcification in center of ducts

Answer 18

Subtype of DCIS known as Comedocarcinoma

Question 19

Ecxematous patches on nipple

Answer 19

from underlying DCIS; Pagets of breast (not vulva)

Question 20

Large cells in epidermis with clear halo

Answer 20

Paget cells

Question 21

malignant epithelium of vulva; erythematous, pruritic, ulcerated skin

Answer 21

Extramammary Paget

Question 22

Firm, fibrous, “rock-hard” mass with sharp margins and small, glandular, duct-like cells

Answer 22

Invasive ductal breast cancer

Question 23

Stellate infiltration

Answer 23

Invasive ductal breast cancer; worst and most invasive type

Question 24

Orderly rows of cells “Indian File”

Answer 24

Invasive lobular breast cancer

Question 25

Fleshy, cellular, lymphocytic (plasma) infiltrate

Answer 25

Medullary breast cancer; good prognosis

Question 26

Dermal lymphatic invasion by breast carcinoma; Peau d'orange

Answer 26

Inflammatory breast cancer (neoplastic cells block lymphatic drainage

Question 27

Most common cause of "breast lumps" from 25 to menopause; presents with premenstrual breast pain and multiple lesions; fluctuates in size

Answer 27

Proliferative Breast Disease

Question 28

Types of Proliferative Breast disease

Answer 28

Fibrosis; cystic; sclerosing adenosis; epithelial hyperplasia

Question 29

hyperplasia of breast stroma; breast pain with periods

Answer 29

Fibrosis type of proliferative breast disease

Question 30

Fluid filled; blue dome; ductal dilation

Answer 30

Cystic type of prolfierative breast disease

Question 31

Increased acini and intralobular fibrosis; associated with calcifications

Answer 31

Sclerosing adenosis; commonly confused with cancer

Question 32

Increased number of epithelial cell layers in terminal duct lobule; increased risk of carcinoma with atypical cells

Answer 32

Epithelial Hyperplasia type os proliferative breast disease

Question 33

Breast abscess during breast feeding

Answer 33

Acute mastitis

Question 34

Most common bacteria that causes acute mastitis

Answer 34

S. aureus

Question 35

Tx of acute mastitis

Answer 35

Dicloxacillin and continued breast feeding

Question 36

Injury to breast tissue; abnormal calcification

Answer 36

Fat necrosis

Question 37

Causes of Gynecomastia

Answer 37

Hyperestrogenism (cirrhosis, testcular tumor, puberty, old age); Klinefelter, Spironolactone, marijuana, digitalis, estrogen, cimetidine, alcohol, heroin, dopamine D2 antagonist, ketoconazole