Brief History of HIV

Question 1

1884 - 1924

Answer 1

SIV (simian immunodeficiency virus) crosses to HIV
○ It was mutated and infected humans
○ Strains of SIV found in a number of chimpanzee colonies in south - east Cameroon (ancestor of HIV-1)
§ HIV-1 originated from SIVs in different primate species than HIV-2
§ HIV-1: strains M, N and O are closely related to SIVcpz/S, from the chimpanzee subspecies Pan troglodytes
§ HIV-2: strains A and B are closely related to SIVsmm, from Sooty Mangabey monkeys

Question 2

1930s

Answer 2

Spread through Africa

Question 3

1959

Answer 3

First sample testes in man

Question 4

1960

Answer 4

First sample testes in woman

Question 5

1966

Answer 5

First case of a 16 year old male in USA

Question 6

1981

Answer 6

5 homosexual men in US presented with rare infections and no immune system