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1
Q

Epidermal melanin unit.

A

1:36

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2
Q

Epidermal turnover time.

A

56 days

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3
Q

Granules present in Stratum lucidum

A

Eledin granules

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4
Q

Granules in stratum granulosum.

A

Keratohyaline(fillagrin)
Lamellar bodied/odland bodies

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5
Q

Cells in stratum spinosum

A

APC - Langerhans cells (CD 207)
BM- MACROPHAGES

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6
Q

Cells in str Basale

A

Merkel cells
Melanocytes

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7
Q

Merkel cells

A

Ectodermal
SALT RECEPTOR
CK 7- CK 20 +

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8
Q

Melanocytes

A

Neural crest cell derivative
S-100,Melan A, HMB 45

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9
Q

Define parakeratosis
Seen in

A

Psoriasis

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10
Q

Hyperkeratosis seen in

A

Psoriasis, LP

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11
Q

Orthokeratosis seen in

A

Hyper-para
LP

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12
Q

Hp of Psoriasis

A

●Hyperkeratosis
●Parakeratosis
●Club shaped rete ridges
●Munro’s microabsess in str corneum
●Spongiform pustules of kogoj in spinous or granular layer

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13
Q

Hp of Lichen planus

A

●Orthokeratosis
●Hypergranulosis
●Max Joseph space-wickham striae
●Civatte bodies
●Saw tooth appearance of Rete ridges
●Lichenoid band of inflammation

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14
Q

Erythema Nodosum seen in

A

Sulpha drugs
Sarcoidosis
(Loefgren syndrome)
IBD/TB/ BEHCET’s

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15
Q

Erythema Marginatum

A

ARF

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16
Q

E multiforme

A

Hsv mycoplasma
Chloroquine
NSAIDS

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17
Q

E migrans in

A

Lyme’s disease

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18
Q

Erythema seen in Paraneoplastic syndrome

A

E. Gyratum ripens

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19
Q

Skin and nail fx of psoriasis

A

Erythematous papulo squamous lesion with silvery scales
Irregular pitting
Oil drop pattern(pathognmonic)
Subungal hyperkeratosis
Splincter h’age

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20
Q

Grattage test done for

A

Psoriasis (auspitz sign positive)
Also ass with berkeley membrane

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21
Q

Psoriasis with h/o URTI and raindrop pattern lesion over trunk?

A

Guttate psoriasis
DOC Macrolides

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22
Q

H/o sudden withdrawl of steroids

A

Pustular psoriasis
Doc- Acitretin(washout period- 3 yrs)
K/a Impetigo herpetiformis in pregnancy

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23
Q

Koebner phenomenon
Seen in

A

Morphologically similar lesion on trauma
Seen in LPV(LP, PSORIASIS,VITILIGO)

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24
Q

Pseudo koebner

A

Auto innoculation
Seen in Viral warts(HPV, Mol contagiosum)

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25
Reverse koebner
Lesion heals on trauma Psoriasis
26
LP featured
Purple Pruritic Papule Plane topped polygonal Pup tentibg On plexors Pterigium of nails With wichham striae
27
Hp fx of lichen nitidus
Claw clutching a ball pattern
28
P rosea fx?
Christmas tree pattern Ass with HHV 6/7 Herald patch ( cigarette paper with colarette scales) Spares palms and soles Rx Reassurance
29
P versicolor
Hypo + Hyperpigmented lesion M. Furfur fungi -fried egg colonies On KOH mount- sphagetti and meatball pattern
30
Fried egg appearnce seen in
M. Furfur Mycoplasma HC leukemia Oligodendroma
31
Reiter sx
Occurs after pre-existing GI/ STD Infection by Campylobacter/ shigella. Can't see(conjunctivitis) Can't pee(urethritis) Can't climb a tree (arthritis)
32
Two tough names ass with reiter sx
Keratoderma blenorrhagicum Circinate balanitis
33
Bullous impetigo caused by
Staph- SSSS, SJS/TEN
34
Erisipelas
Caused by strep Well defined Raised lesion (st antony fire) Upper 1/2 dermis + lymphatics involved
35
Cellulitis
Diffuse Lower half of dermis + sc tissue involved
36
Meleney gangrene
Infn of surgical wound Orange burrowing lesion
37
Erythrasma caused by
C. Minutissimum On wood's lamp - coral red
38
Ca ATPase 2A2 defect
Darrier's ds V shaped nail defect
39
Ca ATPase 2C1 defect
Hailey hailey ds Longitudinal lines seen on nails Hp: delapidated brick wall appearance
40
Scarring alopecia is seen in
Tinea capitis Lp DLE +- sec syphillis
41
Non scarring alopecia With 3 month of stressor
Tenogen effluvium
42
Non scarring alopecia after chemo
Anagen effluvium
43
Non scarring alopecia in accessible areas
Trichotillomania
44
Crusting scutula organism
T schonleini
45
Kerion orgnsm
T mentagrophyte Hair perforation test positive
46
Male pattern baldness
Hamilton pattern
47
Female pattern baldness.
Ludwig pattrn
48
Trichophyton
Involves skin hair(endothrix) and nails Microconidia: pencil shape
49
Exclamatory mark sign Regular nail pitting Going white overnight (white hair spared) lymphocytes near hair bulb
Alopecia areata
50
Alopecia totalis
Total loss of scalp hair
51
Alopecia Universalis
loss of all body hair
52
Ophiasis (alopecia)
Alopecia along Scalp margins.
53
sisapho pattern of hair loss
Hair loss spares the sides & back of head.
54
Androgenic alopecia treatment
Minoxidil (topical) & finasteride
55
Trichophyton, Microsporum, Epiderm mophyton microconidia appearance
Pencil ,Spindle,club shape micro conidia
56
LeSion with central Scarring
Lupus Vulgaris
57
Lesion with Central clearing
Tinea
58
Lesion with central crusting
Kala azar
59
MBL Characteristics
> 5 Skin lesion >1 Nerve involvement SSS AFB positive MDT duration 12M
60
Leprosy dose
Rifampicin 600 mg OAMS Dapsone 100 mg OD clofazimine 300mg OAMS+ 50mg OD
61
Type 1 Lepra reaction * HSN RX * seen in _ * Relation to Rx * C/F * Systemic Involvement * Treatment
●Type 4 HSN ●BB /BT /BL ●within 12 M Pre-existing lesion #+ ●raised &tender ●No ●1st line- NSAIDS DOC-Steroids
62
Type 2 Lepra reaction * HSN RX * seen in _ * Relation to Rx * C/F * Systemic Involvement * Treatment
●Type 3 ●LL ●No Relation ●New nodular lesion ●fever, arthralgia, Orchitis ●DOC- Steroids Most effective- Thallitomide DO NOT STOP MDT.
63
Thin, off white discharge with fishy odour No inflammation Lab finding_ pH> 4.5, Clue cells positive whiff test
Bacterial vaginosis (Gardnerella vaginalis) Rx- Metronidazole, Clindamycin
64
Thin yellow-green malodorous ,frothy discharge Strawberry vagina Lab - pH >4.5 , motile trichomonasds +nt
Rx- Metronidazole or Clindamycin
65
Thick cottage cheese discharge vaginal inflammation +nt Lab- Normal pH , Pseudohyphae
Candida vaginitis Rx fluconazole
66
STD KIT 1
For cervical discharge ,urethral discharge, painful scrotal swelling Tab Azithromycin 1 gm od stat + tab Cefixime 400 mg od stat Treat all recent partners ( sympt partner in cervical discharge)
67
STD kit-2
Green Vaginal discharge Tab secnidazone 2g OD Stat + cap fluconazole 150 mg OD Stat
68
kit 3 I white
Genital ulcer non herpetic inj Benzathine penicillin(2-4 Mv)- vial Tab azithral 1 g Treat all sexual Parther for 3 months
69
kit_4 (Blue)
Doxycycline+ Azithromycin
70
kit 5/ Red
Genital ulcer- Herpetic Tab Acyclovir- 400m g TDS for 7 days
71
kit 6 / Yellow
Lower abd pain Tab cefixime 400 mg OD stat + tab Metronidazole 400 mg BD x 14 days + Doxycycline 100 mg BD x 14 days
72
kit 7 /Black
Inguinal Bubo Tab Azithromycin + Tab Doxy
73
Painful genital ulcers with vesicles and erosion
HSv
74
Painful genital ulcer with raised lesion
Chancroid(H. Ducreyi)
75
Painless hard and indurated genital ulcer with painful and rubbery LN
Chancre (syphillis)
76
Painless beefy red genital ulcer
Granuloma inguinale
77
Painless genital ulcer with inguinal bubo
LGV (chlamydia)
78
Pemphigus
Flaccid bullae Dsg 1 - subcorneal(granulosum layer) P. Foliaceus, P. Erythematosus Dsg 3 - suprabasal (spinosum layer) P. Vulgaris, p vegetans(oral lesion +nt)
79
Bullous pemphigoid
BP ag Tense bullae with pruritis(eosinophils) IF : IgG/c3 -DE jnc against BP ag
80
CBD OF CHILDHOOD
Linear IgA deposition String of pearls appearance Rx Dapsone
81
Dermatitis herpetiformis
Extensor pruritis IF : picket fence granular deposition of IgA @ dermal papillae Hp: Neutrophils + with papillary microabscess
82
Wardenburg syndrome
Piebaldism + heterochromia iridis
83
Contact leukoderma
MBEH
84
Chemical irritant in alta
Crocein Scarlet MOO Yellow 3 solvent
85
Chemical irritant in Bindi
PTBP
86
Mc chemical in cement
Nickel
87
Chemical in hair dye
Parabutyl catechol
88
BCC
Raised pearly nodule True palisading
89
Mycoises fungoides
Pautrier's microabscess Epidermotropism Cerebriform nucleus
90
ABCDE RULE OF MELANOMA
Asymmetry Borders Color Diameter Evolving M imp prognostic factor: Breslow depth
91
Actinic keratosis
Cutaneous horn Premalignant to Sq c ca
92
Seborrhoeic keratosis
Stuck on brownish appearance Not premalignant.
93
NF 1 chr?
17
94
NF2 chromosome?
22
95
All neurocutaneous sx are AD except?
SWS (SPORADIC) At chr 9 Gene GNAQ
96
Tuberous sclerosis chr?
9,16 1- Hamartin 2- Tuberin
97
VHL chr and gene
Chr 3p at HIF GENE (VEGF Increase)
98
ATM
AR Chr 11 at ATM gene

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