butyrophenones and phenothiazines

Question 1

example of phenothiazines

Answer 1

acepromazine

Question 2

example of butyrophenones

Answer 2

azaperone

Question 3

antipsychotics are antagonists of which type of receptor

Answer 3

D2 (dopamine)

Question 4

dopamine receptors are what type of receptors

Answer 4

heptahelical G-protein coupled receptors

Question 5

what are the non-dopaminergic effects

Answer 5

autonomic nervous system

• antiadrenergic (a1 and a2 receptors) (hypotension)
• increased affinity for a1 and a2 receptors more than dopamine receptors

Question 6

absorption of acepromazine

Answer 6

• relatively slow after IM administration (15-30min)
• poor oral bioavailability (~20% but variable)

Question 7

distribution of acepromazine

Answer 7

• highly lipophilic, highly membrane or protein bound - widely distributed
• accumulate in brain, lung or other VRG tissues
• enter fetal circulation and breast milk

Question 8

acepromazine CNS

MAC

Answer 8

mac reduction - 30-40% (decreases inhalent amount)

Question 9

acepromazine: hematologic system

Answer 9

• Hct decreased by 20-50% in dogs and horses
• due to splenic sequestration
• occurs within 30 min and persists for 2 hrs
• mag and duration of effect is dose dependent
• platelet aggregation is also inhibited - minimal hemostatic significance

Question 10

acepromazine: integumentary system

Answer 10

antihistaminergic effects - not suitable for use in allergic skin testing patients