Buzzin on WBCs Flashcards
(29 cards)
AMML
MPO and nonspecific esterase positive
myelo, monocytic (has granules in it)
APL
acute promyelocytic leukemia
DIC, in middle age, Auer rods
t(15;17)
Gilbert’s syndrome
- elevation of indirect, unconjugated bilirubin
- the enzyme that conjugates the bilirubin has decreased funcitoning, thus it is not that severe
- brought on by stress
- see total bilirubin of around 2.5 and indirect bili elevated, along with elevated urinary urobilinogen (around just 2-3 is when its seen in the eyes)
Mild inc. unconjugated bili, TB<3, teenaager/adult thats stressed
reduced activity of UDPGT
Crigler-Najjar I and II
seen in infants
- degree if hyperbilirubinemia is very high
see lots of unconjugated bilirubin due to absent UDPGT
Rotor syndrome
increased conjugated bilirubin, AR inheritence
Dubin-Johnson
- increased conjugated bilirubin
- black pigmented liver
- AR inheritence
indirect vs. direct bilirubin
indirect = unconjugated direct = conjugated
haptoglobin
soaks up bilirubin, it will be low in a case of hemolytic disease
where does hematopoeisis take place at 12 weeks gestation?
in the liver
TdT
premature lymphocyte
CD56
NK cells
sickle cell?
can see infection with parvovirus B19 triggering aplastic anemia (its an infection that looks like redened cheeks, will see fatigue, fainting and fevers)
what do you see in chronic illness anemia?
decreased Fe, decreased TIBC, increased ferritin (anemia of chronic inflammation)
what are hepcidin level be in a patient of anemia with chronic disease?
its an acute phase reactant, would be increased in state of chronic disease
In states in which the hepcidin level is abnormally high such as inflammation, serum iron falls due to iron trapping within macrophages and liver cells and decreased gut iron absorption. This typically leads to anemia due to an inadequate amount of serum iron being available for developing red cells. When the hepcidin level is abnormally low such as in hemochromatosis, iron overload occurs due to excessive ferroportin mediated iron influx.
megaloblastic anemia with hypersegmented neutrophils
seen in B12 deficiency/folate defiency (in other macrocytic anemias you have absence of the hypersegmentation) - these are needed for DNA synthesis
Howell-Jolly bodies
think splenectomy
Leukemoid reaction
an increase in white blood cell count similar to what occurs in people with leukemia. However, the reaction is actually due to an infection or another disease and is not a sign of cancer. Blood counts will usually return to normal when the underlying condition is treated.
Will have HIGH LAP!!!!
- this is different from CML b/c CML will have normal/low LAP
urea breath test
indicative of H. pylori
- this is indicative of Marginal Cell: which is associated with chronic immune stimulation and memory B cells
IgM monoclonal spike?
think hyperviscosity
overexpression of cyclin D1?
mantle cell lymphoma
what are three indolent lymphoplasms?
mantle, marginal, follicular
CD11c, CD25, CD103
hairy cell leukemia
patient has atypical mycobacterium infection?
think hairy cell leukemia
PAX5+
all HL besides lymphocyte predominant
