Buzzwords

Question 1

crew cut x-ray

Answer 1

thalassemia

Question 2

hypersegmented neutrophils

Answer 2

any macrocytic-hyperchromic anemia but think folate or B12 deficiency

Question 3

Fat in bone marrow

Answer 3

aplastic anemia

Question 4

Macrocytic-hyperchromic anemia WITH neuro problems

Answer 4

B12 deficiency anemia

Question 5

Macrocytic-hyperchromic anemia WITHOUT neuro problems

Answer 5

Folate deficiency anemia

Question 6

too much EPO

Answer 6

secondary polycythemia

Question 7

abnormal PML/RARA fusion protein

Answer 7

acute promyelocytic leukemia (a type of acute myelogenous leukemia)

Question 8

no terminal differentiation of myeloid cells

Answer 8

acute myelogenous leukemia

Question 9

proliferation of mature myeloid cells

Answer 9

chronic myelogenous leukemia

Question 10

BCR-ABL fusion –> tyrosine kinase activation

Answer 10

chronic myelogenous leukemia

Question 11

West Philadelphia born and raised chromosome

Answer 11

chronic myelogenous leukemia or B-acute lymphoblastic leukemia/lymphoma (children mostly)

Question 12

MYC oncogene

Answer 12

Burkitt’s lymphoma

Question 13

child with large tumor in jaw or face

Answer 13

Burkitt’s lymphoma

Question 14

starry sky macrophages

Answer 14

Burkitt’s lymphoma

Question 15

Reed Sternberg cells

Answer 15

Hodgkin lymphoma

Question 16

punched-out skull lesions

Answer 16

multiple myeloma

Question 17

viscous blood, red skin

Answer 17

polycythemia

Question 18

trans-retinoic acid is used to treat….

Answer 18

acute promyelocytic leukemia

Question 19

Bence Jones protein

Answer 19

multiple myeloma

Question 20

prostate - peripheral zone

Answer 20

prostate cancer

Question 21

prostate - transitional or central zone

Answer 21

BPH

Question 22

no basal reserve cells

Answer 22

prostate cancer

Question 23

Isolated humps between the glomerular BM and podocytes

Answer 23

Acute poststreptococcal glomerulonephritis

Question 24

breaks in the BM, crescents formed by proliferated parietal cells

Answer 24

Crescentic glomerulonephritis

Question 25

Anti Type IV collagen antibody

Answer 25

Goodpasture syndrome

Question 26

leukocyte casts in urine

Answer 26

acute pyelonephritis

Question 27

proteinaceous casts in the distal convoluted tubules and collecting ducts

Answer 27

acute tubular necrosis

Question 28

Orphan Annie eye nuclei

Answer 28

Papillary thyroid carcinoma

Question 29

moon face

Answer 29

Cushing disease

Question 30

buffalo hump

Answer 30

Cushing disease

Question 31

striations on the skin of stomach

Answer 31

Cushing disease

Question 32

bite cells

Answer 32

G6PDH deficiency

Question 33

moth balls (napthalene)

Answer 33

G6PDH deficiency

Question 34

fava beans

Answer 34

G6PDH deficiency

Question 35

pencil/cigar-shaped cells

Answer 35

iron-deficiency anemia

Question 36

desmoplastic response

Answer 36

comedo DCIS (high grade) OR invasive ductal carcinoma

Question 37

CA-125

Answer 37

cystadenocarcinoma of the ovary

Question 38

signet ring cells

Answer 38

LCIS

Question 39

D cyclin dysregulation

Answer 39

multiple myeloma

Question 40

Erythoplasia of Queyrat

Answer 40

Bowen disease (carcinoma in situ of penis)

Question 41

prominent Leydig cells

Answer 41

cryptorchidism

Question 42

parchment/crinkled

Answer 42

lichen sclerosus of vulva

Question 43

chocolate cysts

Answer 43

endometriosis

Question 44

powder burns

Answer 44

endometriosis

Question 45

mutated mismatch repair and PTEN tumor suppressor gene

Answer 45

endometrioid carcinoma (type 1)

Question 46

whorls of smooth muscle cells

Answer 46

leiomyoma

Question 47

Ashkenazi Jewish women

Answer 47

BRCA2

Question 48

irregular kidney surface

Answer 48

autosomal dominant polycystic kidney disease

Question 49

smooth kidney surface

Answer 49

autosomal recessive polycystic kidney disease

Question 50

vanillylmandelic acid

Answer 50

phaeochromocytoma

Question 51

EBV in endemic cases

Answer 51

Burkitt lymphoma

Question 52

Keratin pearls

Answer 52

keratinizing squamous cell carcinoma of the vulva

Question 53

BCL6/BCL2 gene rearrangements

Answer 53

Diffuse large B cell lymphoma

Question 54

embryonal elements/mixed tumor in kidney

Answer 54

Wilms tumor

Question 55

cigarette smoking

Answer 55

urothelial carcinoma or Grave's disease or acute promyelocytic leukemia

Question 56

coarse chromatin granules

Answer 56

cervical intraepithelial neoplasm (CIN) aka dysplasia

Question 57

nipple discharge

Answer 57

non-comedo DCIS or invasive ductal carcinoma

Question 58

perineural invasion

Answer 58

invasive ductal carcinoma

Question 59

desmoplastic response

Answer 59

invasive ductal carcinoma OR comedo DCIS

Question 60

dirty brown granular casts in urine

Answer 60

acute tubular necrosis

Question 61

schistosomiasis

Answer 61

urothelial carcinoma

Question 62

Gleevec

Answer 62

tx for CML (blocks tyr. kinase binding site)

Question 63

Disappearance of rete pegs

Answer 63

Lichen sclerosus of the vulva