Buzzwords Flashcards
(25 cards)
3rd person auditory hallucinations
schizophrenia
mesocortical dopamine hypoactivity
negative and cognitive symptoms in schizophrenia
subcortical dopamine hyperactvitiy
psychosis
what are the 3 dopamine pathways in the brain
- tuberoinfundibular- concerned with prolactin release
- nigrostriatal- extra pyramidal motor movements
- subcortical and mesocortical- dysregulated in schizophrenia
mesolimbic Da blockade and agonism
blockade= depression
agonism= psychosis
side effects of clozapine
agranulocytosis
weight gain
cardiomyositis
issues surrounding clozapine
need to have tried 2 other anti- psychotis first
consultants to prescribe
monitor once per week for first 6/12 weeks
then once per fortnight for next 6/12 weeks
then once very month there on after
limbic system function
(M2OVE)
motivation memory olfaction visceral afferents emotion
brain changes in schizophrenia
reduced frontal lobe volume ( and reduced grey matter)
enlarged lateral ventricles
reduced grey matter in temporal cortex
what is pressure of thought
varied ideas in abundance
seen in manic patients
what is poverty of thought
patient reports lack or absence of thought
abrupt and complete interruption of stream
seen strongly in schizphrenia
thought blocking
flight of ideas
quickly moving between topic but there IS a link
treatment of EPSE
procyclidine
involved in normal response to threat
amygdala
dampens down amygdala response to threat
pre frontal cortext
OCD management
- SSRI
- other SSRI
- TCA or SSRI
- SSRI or TCA (cloripramine)
used CBT as adjunct
learning difficulties
borderline 70-80 ish
mild 50-59
moderate 35-49
sevre 20-34
profound < 20
becks triad
negative feelings about self, world and future
NMDA agonists
psychotic symptoms
alcohol withdrawel
use what?
use chlordiazepoxide
alcohol withdrawel
when do you get seizures
when do you get delirium
seizures within 48 hours
delirium between 48-72 hours
Eosinophilic inclusions
lewy bodies
risk of hypertensive crisis with MAOIs
treat with Phentolamine infusion
