Buzzwords

Question 1

What is grapefruit juice bad with?

Answer 1

Grapefruit Juice + Statin = BAD!!

Question 2

What does metronidazole interact with?

Answer 2

Alcohol

Question 3

What drug interacts with cranberry?

Answer 3

Warfarin

Question 4

What can amiodarone potentiate the effect of?

Answer 4

Warfarin

Question 5

Can you take statins with clarithromycin?

Answer 5

NO BAD!!

Question 6

What happens if calcium & thyroxine are prescribed together?

Answer 6

Decreased absorption from GI tract

Question 7

What is the effect of warfarin + NSAID?

Answer 7

BLEED (but not with low dose aspirin)

Question 8

What happens if you prescribe ACE inhibitor & spironolactone?

Answer 8

Hyperkalaemia

Question 9

What happens when you prescibe verapamil with digoxin?

Answer 9

Digoxin toxicity

Question 10

What drug interaction can cause serotonin syndrome?

Answer 10

Fluoxetine + phenelzine

Question 11

What are the features of serotonin syndrome?

Answer 11

Autonomic excitation (tremor, hyperthermia) 
Altered mental state 
Neuromuscular excitation (hyperreflexi, myoclonus, rigidity)

Question 12

What syndrome is caused by B1 deficiency?

Answer 12

WERNICKE’S ENCEPHALOPATHY

Question 13

What are the symptoms of Wernicke’s encephalopathy?

Answer 13

Ophthalmoplegia
Ataxia
Confusion

Question 14

What can Wernicke’s encephalopathy lead to?

Answer 14

Korsakoff’s syndrome (confabulation)

Question 15

What is the treatment for Wernicke’s encephalpathy?

Answer 15

Thiamine replacement (Pabrinex)

Question 16

What are the symptomsof delirium?

Answer 16

1. Fluctuating mental state
2. Inattention
3. Disorganised thinking
   and/or
4. Altered level of consciousness
   (1+2 either 3 or 4 or both)

Question 17

When are triptans contraindicated?

Answer 17

IHD
Uncontrolled hypertension
Concurrent use of lithium, SSRI or ergot derivative drugs (such as cabergoline in PD)