C/10. Carbapenem. Monobactams. Beta-lactamase Inhibitors. Pharmacotherapy Of Respiratory Infections.

Question 1

Drugs need to know in this topic

Answer 1

Imipenem
Meropenem
Clavulanate
Tazobactam
Vaborbactam

Question 2

2nd gen of Carbapenem

Answer 2

Imipenem
Meropenem

Broad spectrum
Effective against gram +,-, anaerobes, aerobes)
Serratia, enterobacter, psudomona, acinetobacter
Used in hospital-acquired infections, including pneumonia and sepsis

Parenteral administration
Imipenem is given with cilastatin, a renal dehydropeptidase inhibitor, which inhibits imipenem’s metabolism to a nephrotoxic metabolite
Resistant to most beta-lactamases

MRSA strains are resistatnt to carbapenem
Carbapenemase potentially expressed by Klebsiella, Acinetobacter, Pseudomonas, Enterobacter

Hypersensitivity reaction
GI symptoms
Skin rash
CNS symptoms

Question 3

B-lactamase inhibitors

Answer 3

Clavulanate
Tazobactam
Vaborbactam

Prevent the destruction of B-latam antibiotics by B-lactamases and increase the spectrum of the antibiotic activity
Can be coadministered with B-lactamase-sensitive penicillins