C&P: Intravenous Induction Agents Flashcards Preview

FRCA Anaesthesia > C&P: Intravenous Induction Agents > Flashcards

Flashcards in C&P: Intravenous Induction Agents Deck (60):
1

Chemical Composition: Thiopental

Thiobarbiturate

2

Chemical Composition: Methohexital

Oxybarbiturate

3

Chemical Composition: Propofol

2,6 Di-isopropylphenol

4

Chemical Composition: Ketamine

Phenylcyclidine derivitave

5

Chemical Composition: Etomidate

Imidazole ester

6

Dose (mg/kg): Thiopental

3-7

7

Dose (mg/kg): Methohexital

1-1.5

8

Dose (mg/kg): Propofol

1-2

9

Dose (mg/kg): Ketamine

1-2 (IV), 5-10 (IM)

10

Dose (mg/kg): Etomidate

0.3

11

pKa: Thiopental

7.6

12

pKa: Methohexital

7.9

13

pKa: Propofol

11.0

14

pKa: Ketamine

7.5

15

pKa: Etomidate

4.0

16

pH in solution: Thiopental

10.5

17

pH in solution: Methohexital

11

18

pH in solution: Propofol

6-8.5

19

pH in solution: Ketamine

3.5-5.5

20

pH in solution: Etomidate

8.1

21

Vol of Distribution (L/kg): Thiopental

2.5

22

Vol of Distribution (L/kg): Methohexital

2.0

23

Vol of Distribution (L/kg): Propofol

4.0

24

Vol of Distribution (L/kg): Ketamine

3.0

25

Vol of Distribution (L/kg): Etomidate

3.0

26

Protein Binding (%): Thiopental

80

27

Protein Binding (%): Methohexital

60

28

Protein Binding (%): Propofol

98

29

Protein Binding (%): Ketamine

25

30

Protein Binding (%): Etomidate

75

31

Racemic?: Thiopental

Yes

32

Racemic?: Methohexital

Yes

33

Racemic?: Propofol

No

34

Racemic?: Ketamine

Yes

35

Racemic?: Etomidate

Yes

36

Action: Thiopental

Increased GABA A opening, leading to increased Cl- current

37

Action: Methohexital

Simulates GABA, inhibits NMDA

38

Action: Propofol

Inhibits NMDA and opioid mu receptors (stimulates K and D)

39

Action: Ketamine

Stimulates GABA

40

Action: Etomidate

Nil

41

Metabolites, ?active: Thiopental

Oxidation with active metabolites

42

Metabolites, ?active: Methohexital

Unknown with minimal activity

43

Metabolites, ?active: Propofol

Glucuronidation hydroxylation with inactive metabolites

44

Metabolites, ?active: Ketamine

N-Demethylation hydroxylation with active metabolites

45

Metabolites, ?active: Etomidate

Plasma and hepatic esterases with inactive metabolites

46

Clearance (ml/(kg*min): Thiopental

3.5

47

Clearance (ml/(kg*min): Methohexital

11

48

Clearance (ml/(kg*min): Propofol

30-60

49

Clearance (ml/(kg*min): Ketamine

17

50

Clearance (ml/(kg*min): Etomidate

10-20

51

Elimination Rate (hours): Thiopental

6-15

52

Elimination Rate (hours): Methohexital

3-5

53

Elimination Rate (hours): Propofol

5-12

54

Elimination Rate (hours): Ketamine

2

55

Elimination Rate (hours): Etomidate

1-4

56

Hypersensitivity: Thiopental

Anaphylaxis 1:20,000

57

Hypersensitivity: Methohexital

More common than 1:20,000 (ie theopental), but less severe

58

Hypersensitivity: Propofol

Nil

59

Hypersensitivity: Ketamine

Rashes in 15%

60

Hypersensitivity: Etomidate

Rare